A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases.

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-10-28 DOI:10.1007/s12016-024-09009-y
Kuan-Hua Chu, Bor-Luen Chiang
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Abstract

Regulatory T (Treg) cells are crucial for maintaining immune tolerance by suppressing response to self-antigens and harmless antigens to prevent autoimmune diseases and uncontrolled immune responses. Therefore, using Treg cells is considered a therapeutic strategy treating inflammatory diseases. Based on their origin, Treg cells are classified into thymus-derived, peripherally induced, and in vitro induced Treg cells. Our group discovered a novel Treg cell subset, namely, Treg-of-B (Treg/B) cells, generated by culturing CD4+CD25- T cells with B cells, including Peyer's patch B cells, splenic B cells and peritoneal B1a cells, for 3 days. Treg/B cells express CD44, OX40 (CD134), cytotoxic T-lymphocyte-associated antigen-4 (CD152), glucocorticoid-induced tumor necrosis factor receptor family-related protein (CD357), interleukin-10 receptor, lymphocyte activation gene-3 (CD223), inducible co-stimulator (CD278), programmed-death 1 (CD279), tumor necrosis factor receptor II, and high levels of IL-10, but not forkhead box protein P3, similar to type 1 Treg (Tr1) cells. However, unlike Tr1 cells, Treg/B cells do not express CD103, CD226, and latency-associated peptide. Treg/B cells have been applied for the treatment of some murine models of inflammatory diseases, including allergic asthma, inflammatory bowel disease, collagen-induced arthritis, gout, psoriasis and primary biliary cholangitis. This review summarizes the current knowledge of Treg/B cells.

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由 B 细胞诱导的新型调节性 T 细胞亚群可减轻免疫疾病的严重程度。
调节性 T(Treg)细胞通过抑制对自身抗原和无害抗原的反应来维持免疫耐受,从而预防自身免疫性疾病和失控的免疫反应。因此,使用 Treg 细胞被认为是治疗炎症性疾病的一种治疗策略。根据Treg细胞的来源,可将其分为胸腺来源的Treg细胞、外周诱导的Treg细胞和体外诱导的Treg细胞。我们的研究小组发现了一种新型的Treg细胞亚群,即Treg-of-B(Treg/B)细胞,它是由CD4+CD25-T细胞与B细胞(包括佩尔氏斑块B细胞、脾脏B细胞和腹膜B1a细胞)培养3天产生的。Treg/B细胞表达CD44、OX40(CD134)、细胞毒性T淋巴细胞相关抗原-4(CD152)、糖皮质激素诱导的肿瘤坏死因子受体家族相关蛋白(CD357)、白细胞介素-10受体、白细胞介素-10 受体、淋巴细胞活化基因-3(CD223)、诱导性协同刺激因子(CD278)、程序性死亡 1(CD279)、肿瘤坏死因子受体 II,以及高水平的 IL-10,但不包括叉头盒蛋白 P3,这与 1 型 Treg(Tr1)细胞相似。然而,与 Tr1 细胞不同的是,Treg/B 细胞不表达 CD103、CD226 和潜伏相关肽。Treg/B细胞已被用于治疗一些小鼠炎症性疾病模型,包括过敏性哮喘、炎症性肠病、胶原诱导性关节炎、痛风、银屑病和原发性胆汁性胆管炎。本综述总结了目前对 Treg/B 细胞的认识。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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