Analysis of Risk Factors for Death from Melanoma and Genitourinary Diseases in Male Patients with Cutaneous Melanoma: A Cohort Propensity Score Matching Study.

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S482389

Kaijie Wang, Weiwei Wu, Yongbao Wei, Xianwei Cao

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Abstract

Objective: To analyze the influencing factors of male cutaneous melanoma (CM) patients dying from genitourinary diseases (GUD).

Methods: We searched the surveillance, epidemiology, and end results (SEER) database and extracted data on male CM patients according to the inclusion and exclusion criteria, including male patients whose cause of death was CM (cohort A) or GUD (cohort B). Comparisons between the two cohorts were performed before and after propensity score matching (PSM). An interaction analysis between age and year of diagnosis was also conducted. Cox regression analysis were performed to find the risk factors for death from GUD.

Results: Seven thousand seventy-eight CM patients were included, including 6415 (90.6%) in cohort A and 663 (9.4%) in cohort B. Compared with cohort A, cohort B patients were older (median age 74 ys. vs 65 ys.) and were more under the localized stage and had longer survival time no matter before or after PSM (all p<0.001). The stage was an inhibitory factor for cohort B (p <0.001). After PSM, only age and year of diagnosis were found to be cohort B's promoting factors (p<0.001). The interaction analysis showed that older patients diagnosed in later years (2009-2020) had a higher risk of dying from GUD compared to those diagnosed earlier (p<0.05). Patients with a later year of diagnosis (2009-2020) had a lower median survival time than patients with an earlier year of diagnosis (2000-2008) (p<0.001). When the patient's year of diagnosis was earlier (2000-2008), older patients (>75 ys.) had a higher risk of dying from GUD than younger patients (≤75 ys.) (p<0.001).

Conclusion: We first reported a significant interaction between age and year of diagnosis in male CM patients dying from GUD, highlighting the increased risk in older patients diagnosed more recently. We may pay attention to the possibility of dying from genitourinary diseases for CM patients.

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男性皮肤黑色素瘤患者死于黑色素瘤和泌尿生殖系统疾病的风险因素分析：一项队列倾向评分匹配研究。

目的：分析男性皮肤黑色素瘤患者死于泌尿生殖系统疾病（GUD）的影响因素：分析男性皮肤黑色素瘤（CM）患者死于泌尿生殖系统疾病（GUD）的影响因素：我们检索了监测、流行病学和最终结果（SEER）数据库，并根据纳入和排除标准提取了男性皮肤黑色素瘤患者的数据，包括死因为皮肤黑色素瘤（队列A）或泌尿生殖系统疾病（队列B）的男性患者。在倾向得分匹配（PSM）前后对两个队列进行了比较。此外，还对年龄和诊断年份进行了交互分析。此外，还进行了Cox回归分析，以找出GUD死亡的风险因素：与 A 组相比，B 组患者年龄更大（中位年龄 74 岁 vs 65 岁），且更多处于局部分期，生存时间更长，无论 PSM 前后（均在 75 岁以下），死于 GUD 的风险均高于年轻患者（≤75 岁）（p 结论：我们首次报道了年龄与 GUD 的显著交互作用：我们首次报道了在死于 GUD 的男性 CM 患者中，年龄与诊断年份之间存在明显的交互作用，这突出表明了近期诊断的老年患者的风险增加。我们可以关注 CM 患者死于泌尿生殖系统疾病的可能性。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.