Acute and multigenerational effects of short-chain chlorinated paraffins on the harpacticoid copepod Tigriopus japonicus

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-10-20 DOI:10.1016/j.cbpc.2024.110055
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Abstract

Although the measurement of short-chain chlorinated paraffins (SCCPs) in aquatic ecosystems has increased, limited information is available on their toxic effects on aquatic animals. To evaluate the harmful effects of SCCPs, we assessed their acute impact on 24-h survival and biochemical parameters, as well as their chronic effects on growth and reproduction over three generations in the harpacticoid copepod Tigriopus japonicus. Dose-dependent increases in mortality were observed, with an LC50 value of 74.6 μg L−1 for 24 h. Acute exposure to the LC10 value for 24 h significantly reduced feeding behavior, accompanied by a notable decrease in acetylcholinesterase enzymatic activity. Simultaneously, the intracellular levels of reactive oxygen species increased, along with elevated malondialdehyde contents. Glutathione level was increased by the LC10 value of SCCPs with the induction of enzymatic activities of antioxidant defense components, including glutathione S-transferase, catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. When T. japonicus was continuously exposed to 1/10 of the NOEC and NOEC values for 12 days across three generations (F0–F2), growth retardation was observed in the F2 generation, with delay in the developmental periods from nauplius to adult. Although the total number of nauplii per brood was not significantly altered across generations, a significant delay in the onset of reproduction was observed in the F2 generation. Our findings suggest that even sublethal concentrations of SCCPs can negatively affect the health of copepod populations with consistent exposure.

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短链氯化石蜡对日本栉水母的急性和多代影响
尽管短链氯化石蜡(SCCPs)在水生生态系统中的测量值有所增加,但有关其对水生动物毒性影响的信息却十分有限。为了评估短链氯化石蜡的有害影响,我们评估了短链氯化石蜡对 24 小时存活率和生化参数的急性影响,以及对日本鲎三代生长和繁殖的慢性影响。急性接触 LC10 值 24 小时后,摄食行为显著减少,乙酰胆碱酯酶酶活性明显下降。与此同时,细胞内活性氧水平增加,丙二醛含量升高。随着谷胱甘肽 S-转移酶、过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶等抗氧化防御成分酶活性的诱导,谷胱甘肽的含量在短链氯化石蜡 LC10 值的基础上有所增加。当日本褐藻在三代(F0-F2)中连续暴露于 1/10 的无观测效应浓度和无观测效应浓度值 12 天时,在 F2 代中观察到生长迟缓,从稚鱼到成鱼的发育期延迟。虽然每窝稚鱼的总数量在各代中没有显著变化,但在 F2 代中观察到繁殖开始时间显著延迟。我们的研究结果表明,即使是亚致死浓度的短链氯化石蜡,持续接触也会对桡足类种群的健康产生负面影响。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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