GDF15 Knockout Does Not Substantially Impact Perinatal Body Weight or Neonatal Outcomes in Mice.

IF 3.8 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrinology Pub Date : 2024-10-30 DOI:10.1210/endocr/bqae143

Molly C Mulcahy, Noura El Habbal, JeAnna R Redd, Haijing Sun, Brigid E Gregg, Dave Bridges

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Abstract

Growth differentiation factor-15 (GDF15) increases in circulation during pregnancy and has been implicated in food intake, weight loss, complications of pregnancy, and metabolic illness. We used a Gdf15 knockout mouse model (Gdf15-/-) to assess the role of GDF15 in body weight regulation and food intake during pregnancy. We found that Gdf15-/- dams consumed a similar amount of food and gained comparable weight during the course of pregnancy compared with Gdf15+/+ dams. Insulin sensitivity on gestational day 16.5 was also similar between genotypes. In the postnatal period, litter size and survival rates were similar between genotypes. There was a modest reduction in birth weight of Gdf15-/- pups, but this difference was no longer evident from postnatal day 3.5 to 14.5. We observed no detectable differences in milk volume production or milk fat percentage. These data suggest that GDF15 is dispensable for changes in food intake, and body weight as well as insulin sensitivity during pregnancy in a mouse model.

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GDF15 基因敲除不会对小鼠围产期体重或新生儿预后产生重大影响。

生长分化因子-15（GDF15）在妊娠期间会在血液循环中增加，并与食物摄入、体重减轻、妊娠并发症和代谢性疾病有关。我们利用Gdf15基因敲除小鼠模型（Gdf15-/-）来评估GDF15在孕期体重调节和食物摄入中的作用。我们发现，与 Gdf15+/+ 母鼠相比，Gdf15-/- 母鼠在妊娠期间的食物摄入量和体重增加量相似。不同基因型的母鼠在妊娠第16.5天的胰岛素敏感性也相似。在产后，不同基因型的母鼠产仔数和存活率相似。Gdf15-/-幼崽的出生体重略有下降，但在出生后第3.5至14.5天，这种差异不再明显。我们没有观察到产奶量或乳脂率的差异。这些数据表明，在小鼠模型中，GDF15对于妊娠期间食物摄入量、体重以及胰岛素敏感性的变化是不可或缺的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinology 医学-内分泌学与代谢

CiteScore

8.10

自引率

4.20%

发文量

195

审稿时长

2-3 weeks

期刊介绍： The mission of Endocrinology is to be the authoritative source of emerging hormone science and to disseminate that new knowledge to scientists, clinicians, and the public in a way that will enable "hormone science to health." Endocrinology welcomes the submission of original research investigating endocrine systems and diseases at all levels of biological organization, incorporating molecular mechanistic studies, such as hormone-receptor interactions, in all areas of endocrinology, as well as cross-disciplinary and integrative studies. The editors of Endocrinology encourage the submission of research in emerging areas not traditionally recognized as endocrinology or metabolism in addition to the following traditionally recognized fields: Adrenal; Bone Health and Osteoporosis; Cardiovascular Endocrinology; Diabetes; Endocrine-Disrupting Chemicals; Endocrine Neoplasia and Cancer; Growth; Neuroendocrinology; Nuclear Receptors and Their Ligands; Obesity; Reproductive Endocrinology; Signaling Pathways; and Thyroid.