Functional connectivity density of brain in children with primary nocturnal enuresis: results from a resting-state fMRI study.

IF 6 2区 医学 Q1 PEDIATRICS European Child & Adolescent Psychiatry Pub Date : 2024-10-24 DOI:10.1007/s00787-024-02586-5
Yang Zhang, Yaqin Di, Jing Chen, Xin Du, Jinqiu Li, Qiaohui Liu, Chunxiang Wang, Quan Zhang
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Abstract

Primary nocturnal enuresis (PNE) is a disease characterized by involuntary urination during sleep after the age of five, causing inconvenience and psychological burden to children and their families. The onset of PNE is related to many factors, and in recent years, delayed central nervous system maturation has been considered one of the important causes of PNE. Previous studies have demonstrated functional changes in multiple brain regions in children with PNE. However, these studies either focused on changes in local brain regions or the functional connection (FC) between specific brain regions, and there is currently a lack of research on the whole brain FC in children with PNE. This study analyzed functional connectivity density (FCD) across the entire brain based on voxels and comprehensively evaluated the global FCD (gFCD), local FCD (lFCD), and long-range FCD (lrFCD). Decreased gFCD and lFCD were found in the left temporal lobe and the right posterior cerebellum in the children with PNE compared with the HC. The FCD values in these regions were negatively correlated with the scores of hyperactivity/impulsivity in the children with PNE. This study may help to reveal the neural mechanisms underlying the onset of PNE in children from a new perspective.

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原发性夜间遗尿症儿童大脑功能连接密度:静息态 fMRI 研究结果。
原发性夜间遗尿症(PNE)是一种以五岁以后睡眠时不自主排尿为特征的疾病,给儿童及其家庭带来不便和心理负担。PNE 的发病与多种因素有关,近年来,中枢神经系统成熟延迟被认为是 PNE 的重要病因之一。以往的研究表明,患有 PNE 的儿童大脑多个区域的功能发生了变化。然而,这些研究要么关注局部脑区的变化,要么关注特定脑区之间的功能连接(FC),目前还缺乏对PNE患儿全脑FC的研究。本研究分析了基于体素的全脑功能连接密度(FCD),并全面评估了全脑功能连接密度(gFCD)、局部功能连接密度(lFCD)和长程功能连接密度(lrFCD)。与正常儿童相比,PNE患儿左侧颞叶和右侧小脑后部的gFCD和lFCD均有所降低。这些区域的FCD值与PNE患儿的多动/冲动评分呈负相关。这项研究有助于从一个新的角度揭示诱发儿童神经衰弱的神经机制。
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来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
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