Skin Rejuvenation by Modulation of DNA Methylation

IF 3.5 3区医学 Q1 DERMATOLOGY Experimental Dermatology Pub Date : 2024-10-23 DOI:10.1111/exd.70005

Elke Grönniger, Heiner Max, Frank Lyko

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Abstract

Skin aging is driven by a complex set of cellular pathways. Among these, epigenetic mechanisms have garnered particular attention, because of their sensitivity to environmental and lifestyle factors. DNA methylation represents the longest known and best understood epigenetic mechanism. We explain how DNA methylation might function as an interface between the environment and the genome of human skin. Exposures to different environmental factors and lifestyles are known to modulate age-related methylation patterns, as illustrated by their effect on DNA methylation clocks. Human skin provides a particularly well-suited tissue for understanding age-related methylation changes and it has been shown recently that modulation of DNA methylation can induce skin rejuvenation. We explain how the use of mildly demethylating agents can be safeguarded to ensure the specific removal of age-related DNA methylation changes. We also identify important areas of future research, leading to a deeper understanding of the mechanisms that drive epigenetic aging and to the development of further refined intervention strategies.

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通过调节 DNA 甲基化实现皮肤年轻化。

皮肤老化是由一系列复杂的细胞途径驱动的。其中，表观遗传机制因其对环境和生活方式因素的敏感性而受到特别关注。DNA 甲基化是已知时间最长、理解最透彻的表观遗传机制。我们将解释 DNA 甲基化是如何在环境和人类皮肤基因组之间发挥作用的。众所周知，暴露于不同的环境因素和生活方式会调节与年龄相关的甲基化模式，对 DNA 甲基化时钟的影响就说明了这一点。人类皮肤是了解与年龄相关的甲基化变化的一个特别合适的组织，最近的研究表明，调节 DNA 甲基化可诱导皮肤年轻化。我们解释了如何使用温和的去甲基化剂，以确保专门去除与年龄相关的 DNA 甲基化变化。我们还确定了未来研究的重要领域，以便更深入地了解表观遗传衰老的驱动机制，并制定进一步完善的干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Dermatology 医学-皮肤病学

CiteScore

6.70

自引率

5.60%

发文量

201

审稿时长

2 months

期刊介绍： Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.