A Paintable Small-Molecule Hydrogel with Antimicrobial and ROS Scavenging Activities for Burn Wound Healing.

IF 5 3区 化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-09-26 DOI:10.3390/gels10100621
Qingchun Ji, Kehan Chen, Han Yi, Bingfang He, Tianyue Jiang
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Abstract

Delayed wound healing induced by bacterial infection and a persistent inflammatory response remains a great clinical challenge. Herein, we reported a paintable, anti-bacterial, and anti-inflammatory Nap-F3K-CA (Nap-Phe-Phe-Phe-Lys-Caffeic Acid) hydrogel for burn wound management based on caffeic acid (CA)-functionalized short peptides (Nap-Phe-Phe-Phe-Lys). Hydrogels are assembled by non-covalent interactions between gelators, and the incorporation of CA promotes the self-assembly of the hydrogel. After being applied to burn wounds, the hydrogel effectively adapted to irregular wound beds and maintained a moist protective environment at the wound. The Nap-F3K-CA hydrogel can scavenge ROS to relieve oxidative damage and downregulate proinflammatory levels. The Nap-F3K-CA hydrogel also displayed potent antibacterial activity against Gram-positive and Gram-negative bacteria, which reduced the incidence of wound infections. Moreover, the hydrogel exhibited good biocompatibility and hemostatic function. In vivo experiments demonstrated that the Nap-F3K-CA hydrogel significantly accelerated the repair of the skin structure including promoting collagen deposition, vascular regeneration, and hair follicle formation. These findings proved the clinical application potential of the Nap-F3K-CA hydrogel as a promising burn wound dressing.

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具有抗菌和清除 ROS 活性的可涂抹小分子水凝胶,用于烧伤伤口愈合。
细菌感染和持续炎症反应导致的伤口延迟愈合仍然是一个巨大的临床挑战。在此,我们报告了一种用于烧伤伤口管理的可涂抹、抗菌和抗炎的 Nap-F3K-CA(Nap-Phe-Phe-Lys-Caffeic Acid)水凝胶,它基于咖啡酸(CA)功能化短肽(Nap-Phe-Phe-Lys)。水凝胶是通过凝胶体之间的非共价作用组装而成的,CA 的加入促进了水凝胶的自组装。将水凝胶应用于烧伤创面后,它能有效地适应不规则的创面,并在创面保持湿润的保护环境。Nap-F3K-CA 水凝胶可以清除 ROS,缓解氧化损伤,降低促炎水平。Nap-F3K-CA 水凝胶对革兰氏阳性菌和革兰氏阴性菌也有很强的抗菌活性,从而降低了伤口感染的发生率。此外,该水凝胶还具有良好的生物相容性和止血功能。体内实验表明,Nap-F3K-CA 水凝胶能明显加快皮肤结构的修复,包括促进胶原蛋白沉积、血管再生和毛囊形成。这些研究结果证明了 Nap-F3K-CA 水凝胶作为烧伤创面敷料的临床应用潜力。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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