Tuning Antioxidant Function through Dynamic Design of Chitosan-Based Hydrogels.

IF 5 3区 化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-10-13 DOI:10.3390/gels10100655
Manuela Maria Iftime, Gabriela Liliana Ailiesei, Daniela Ailincai
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Abstract

Dynamic chitosan-based hydrogels with enhanced antioxidant activity were synthesized through the formation of reversible imine linkages with 5-methoxy-salicylaldehyde. These hydrogels exhibited a porous structure and swelling capacity, influenced by the crosslinking degree, as confirmed by SEM and POM analysis. The dynamic nature of the imine bonds was characterized through NMR, swelling studies in various media, and aldehyde release measurements. The hydrogels demonstrated significantly improved antioxidant activity compared to unmodified chitosan, as evaluated by the DPPH method. This research highlights the potential of developing pH-responsive chitosan-based hydrogels for a wide range of biomedical applications.

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通过壳聚糖水凝胶的动态设计调节抗氧化功能
通过与 5-甲氧基水杨醛形成可逆的亚胺连接,合成了具有增强抗氧化活性的动态壳聚糖基水凝胶。经 SEM 和 POM 分析证实,这些水凝胶具有多孔结构,其溶胀能力受交联度的影响。通过核磁共振、在各种介质中的溶胀研究和醛释放测量,确定了亚胺键的动态性质。通过 DPPH 法评估,与未改性壳聚糖相比,水凝胶的抗氧化活性明显提高。这项研究凸显了开发具有 pH 响应性的壳聚糖水凝胶在广泛的生物医学应用中的潜力。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
期刊最新文献
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