ANALYSIS OF THE CLINICAL EFFECTIVENESS OF USING THE CREATED COMBINED FIBRIN-BONE SCAFFOLD FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS OF THE JAWS.

Abstract

The aim of the study was the clinical study of the framework ability of the PRF scaffold obtained by simultaneous centrifugation of the patient's blood and bone-plastic material.

Materials and methods: A total of 60 patients, aged between 20 and 50 years, with radicular cysts of the jaws, were selected for inclusion into the clinical studies. All patients were divided into groups I and II, who underwent cystectomy and bone plastic surgery according to the standard technique using mineralized CenoBone®. However, group II used a scaffold prepared according to the protocol developed by us (patent №136410 and patent №156181) using a titanium Ti-6Al-4V filter developed by us (patent № 152966).

Results: The results of the aforementioned postoperative radiological examinations confirm the efficacy of the filter, and the technique devised by our research team, which enables the creation of a stable fibrin matrix with embedded granules of bone-plastic material. The efficacy of the treatment was evidenced by the simultaneous uniform regeneration of bone tissue across the entire thickness of the defect in group II, with a success rate of 86.66%. This is evidenced by the organized architecture of bone tissue with a pronounced trabecular pattern, which correlated with bone density indices from 715.18+14.33 to 652.42+27.34 HU. In this group of patients, these values corresponded to the intact bone. In contrast, in 22 (77.08%) patients of group I, the predominant bone structure was compact, with values ranging from 965.47+21.25 to 876.26+24.67 HU. This observation is believed to be attributed to the presence of unresorbed material granules, which form a compact framework for bone germination. Nevertheless, among the 22 patients in group I, only 13 (59.09%) exhibited complete restoration of the defect, while the remaining 9 (40.91%) displayed indications of merely peripheral bone restoration, characterized by a pronounced granular pattern in the centre.

Conclusions: The stable combined fibrin scaffold obtained by us, has a pronounced osteoconductive and osteoinductive effect, which is reflected in the complete restoration of bone tissue throughout the thickness of the defect.