CHARACTERIZATION OF SERUM SERINE PROTEASE BIOCHEMICAL PROFILE IN PATIENTS WITH RENAL FAILURE.

Abstract

The present study meticulously delineates the biochemical alterations in serine protease activity and various life variables in patients with kidney failure compared to a control group. By evaluating 160 samples, comprising 80 from individuals with renal failure and 80 from healthy controls, the researchers observed a significant elevation in serine protease activity among kidney failure patients (274.38 ± 1.55 U/L) relative to the control group (173.78 ±1.49 U/L). Beyond serine protease, other enzymes such as lactate dehydrogenase, basal phosphatase, myeloperoxidase, peroxidase, and aspartate aminotransferase also showed heightened activities in renal failure patients; alanine aminotransferase similarly exhibited a notable increase. Conversely, catalase and arylesterase activities were markedly reduced in these patients compared to controls. The mineral profile revealed substantial decrements in calcium, iron, copper concentrations alongside potassium levels in kidney failure sufferers while showing pronounced increments in phosphate, zinc, and sodium concentrations. Furthermore, protein profiles indicated a stark decrease in total protein, albumin levels along with triglycerides and various cholesterol forms except for high-density lipoprotein cholesterol which increased significantly alongside urea, creatinine and glucose levels; globulin and uric acid also saw considerable elevations when contrasted with the control group's data. These comprehensive findings underscore the profound metabolic disruptions inherent to kidney failure while providing pivotal insights into enzyme activities and mineral imbalances associated with this condition.