INFLAMMATORY FACTORS IN DISSECTION OF THORACIC AORTIC ANEURYSM.

Abstract

In recent years, the prevalence of thoracic aortic aneurysm has increased, and in most cases this pathological condition is diagnosed accidentally. The aim of the current study was to determine the relationship of clinical, laboratory and morphological data with the presence of aorta wall dissection in patients with thoracic aortic aneurysm to reveal factors associated with aorta dissection.

Materials and methods: The following data of 109 patients mean aged of 53 years with thoracic aortic aneurysm (43 patients with aortic dissection) were analyzed: presence/absence of arterial hypertension, indicators of general blood analysis and blood biochemistry, immunomorphological characteristics of the expression of Von Willebrand factor.

Results: Statistically significant differences were found between the incidence of arterial hypertension with respect to the presence or absence of aortic dissection (p=0.002), the relationship between the content of lymphocytes (p=0.021), segmented neutrophils (p=0.001) and the presence of Von Willebrand factor in the medial layer of the aorta, i.e., the prevalence of vasa vasorum (p=0.018), with aortic dissection. The average expression area of Willebrand factor in the medial layer of the aorta during dissection was 3.6 (1.5)%, and in patients without aortic dissection - 0.8 (0.3)%.

Conclusion: The results of the study indicate that aortic dissection in patients with thoracic aortic aneurysm is associated with high blood pressure and is accompanied by the development of an inflammatory reaction.