Performance of instrumental activities of daily living in patients with haemophilic arthropathy. A cross-sectional cohort study.

IF 3 2区 医学 Q2 HEMATOLOGY Haemophilia Pub Date : 2024-10-24 DOI:10.1111/hae.15114
Marta Elisa Seoane-Martín, Rubén Cuesta-Barriuso, María Carmen Rodríguez-Martínez
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Abstract

Background: The development of haemophilic arthropathy causes joint damage that leads to functional impairment that limits the performance of activities in patients with haemophilia. The aim was to identify the best predictive model for performing instrumental activities of daily living in adult patients with haemophilia arthropathy.

Methods: Cross-sectional cohort study. 102 patients were recruited. The dependent variable was the performance of instrumental activities of daily living (Lawton and Brody scale). The dependence on the performance of activities of daily living was the dependent endpoint (Barthel scale). The secondary variables were joint damage (Hemophilia Joint Health Score), pain intensity, and clinical, anthropometric, and sociodemographic variables.

Results: The degree of dependence, joint damage, pain intensity, and marital status (Cp = 5.60) were the variables that best explain the variability in the performance of instrumental activities of daily living (R2 adj = 0.51). Loss of predictive capacity is acceptable with good mean internal (R2 mean = 0.40) and external (R2-r= 0.09) validation. According to the predictive pattern obtained, patients with haemophilia, who were married, without joint pain or damage, and independent in their day-to-day lives, had a score of 7.91 points (95% CI: 7.42; 8.39) in the performance of instrumental activities of daily living.

Conclusions: The predictive model for the functional capacity of instrumental activities of daily living in haemophilia patients encompasses factors such as level of autonomy, joint impairment, pain severity, and marital status. Notably, despite the presence of joint damage, individuals with haemophilia exhibit a significant level of independence in carrying out both basic daily tasks and instrumental activities of daily living.

International registration number: Id NCT04715100.

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血友病关节病患者的日常生活工具活动能力。一项横断面队列研究。
背景:血友病关节病的发生会造成关节损伤,从而导致功能障碍,限制血友病患者的活动能力。研究旨在确定血友病关节病成年患者进行日常生活工具性活动的最佳预测模型:方法:横断面队列研究。方法:横断面队列研究。因变量是日常生活工具性活动的表现(劳顿和布罗迪量表)。日常生活活动能力的依赖性是依赖终点(巴特尔量表)。次要变量为关节损伤(血友病关节健康评分)、疼痛强度以及临床、人体测量和社会人口学变量:结果:依赖程度、关节损伤、疼痛强度和婚姻状况(Cp = 5.60)是最能解释日常生活工具性活动能力变异的变量(R2 adj = 0.51)。预测能力的丧失是可以接受的,内部(R2 平均值 = 0.40)和外部(R2-r2 = 0.09)验证结果良好。根据所获得的预测模式,已婚、无关节疼痛或损伤、日常生活独立的血友病患者在日常生活工具性活动方面的得分为 7.91 分(95% CI:7.42;8.39):血友病患者日常生活工具性活动能力的预测模型包括自主程度、关节损伤、疼痛严重程度和婚姻状况等因素。值得注意的是,尽管存在关节损伤,血友病患者在完成基本日常任务和日常生活工具性活动方面仍表现出相当程度的独立性。
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来源期刊
Haemophilia
Haemophilia 医学-血液学
CiteScore
6.50
自引率
28.20%
发文量
226
审稿时长
3-6 weeks
期刊介绍: Haemophilia is an international journal dedicated to the exchange of information regarding the comprehensive care of haemophilia. The Journal contains review articles, original scientific papers and case reports related to haemophilia care, with frequent supplements. Subjects covered include: clotting factor deficiencies, both inherited and acquired: haemophilia A, B, von Willebrand''s disease, deficiencies of factor V, VII, X and XI replacement therapy for clotting factor deficiencies component therapy in the developing world transfusion transmitted disease haemophilia care and paediatrics, orthopaedics, gynaecology and obstetrics nursing laboratory diagnosis carrier detection psycho-social concerns economic issues audit inherited platelet disorders.
期刊最新文献
The haemophilia joint health score for the assessment of joint health in patients with haemophilia. Performance of instrumental activities of daily living in patients with haemophilic arthropathy. A cross-sectional cohort study. A novel gene editing lexicon strategy for the haemophilia community: Research plan for development and preliminary results. Breaking barriers in haemophilia A care: One-year real-world experience with emicizumab prophylaxis at Civil Service Hospital, Kathmandu, Nepal. Moderate haemophilia A: Recommendations from a Spanish panel of experts.
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