Effectiveness of Eupatorium Perfoliatum 30C in Preventing Dengue Fever-A Prospective, Community-Based, Open Label, Parallel Cohort Study in Delhi, India.

IF 1.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Homeopathy Pub Date : 2024-10-24 DOI:10.1055/s-0044-1788663

Debadatta Nayak, Lovepreet Kaur, Rupali Bhalerao, Karanpreet Nahar, Hanuman Ram, Pawan Sharma, Ankit Gupta, Smita Singh, Anil Khurana, Raj Kumar Manchanda

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Abstract

Objective: The study was undertaken to evaluate the protective effect of Eupatorium perfoliatum (EP) 30C on the incidence of dengue fever.

Design: This study was designed as a prospective, open label, parallel cohort study.

Interventions: Participants were enrolled in two medicine cohort (MC) communities and one control cohort (CC) community. Participants in MC who were more than 5 years of age received four medicated globules and those aged between 1 and 5 years received two medicated globules of EP 30C once a week for 10 weeks. Participants in CC received no medical intervention. Both cohorts received information and educational material regarding dengue.

Outcome measures: The primary outcome was incidence of dengue cases based on laboratory confirmation or the clinical definition of dengue as per the case definition notified by the National Vector-Borne Disease Control Program, Government of India, during the 14 weeks of intervention and observation.

Results: The analysis included 20,607 participants residing in three slums of Delhi, of which MC and CC included 15,298 and 5,309 participants respectively. The overall protective effect of EP 30C in MC against probable/laboratory-confirmed dengue was 59.59% (95% confidence interval [CI], 50.74 to 66.85, p = 0.0001). The overall protective effect of EP 30C against laboratory-confirmed dengue was 72.78% (95% CI, 54.45 to 83.74, p = 0.0001): 26 cases per 15,298 (0.13 per 1,000 person-weeks) in MC versus 33 cases per 5,309 (0.46 per 1,000 person-weeks) in CC.

Conclusion: The use of EP 30C was associated with some protection against probable and laboratory-confirmed dengue.

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在印度德里开展的一项以社区为基础的前瞻性、开放标签、平行队列研究--30C 欧鼠李对预防登革热的功效。

研究目的本研究旨在评估 30C 茵陈对登革热发病率的保护作用：本研究是一项前瞻性、开放标签、平行队列研究：干预措施：参与者被纳入两个药物队列（MC）社区和一个对照队列（CC）社区。5岁以上的MC参与者接受4粒药球治疗，1至5岁的参与者接受2粒EP 30C药球治疗，每周一次，持续10周。CC组的参与者没有接受任何医疗干预。两组参与者都收到了有关登革热的信息和教育材料：主要结果是在 14 周的干预和观察期间，根据实验室确认的登革热病例发生率，或根据印度政府国家病媒传播疾病控制计划公布的登革热病例临床定义的发生率：分析包括居住在德里三个贫民窟的 20,607 名参与者，其中 MC 和 CC 分别包括 15,298 和 5,309 名参与者。在 MC 中，EP 30C 对可能/实验室确诊登革热的总体保护效果为 59.59%（95% 置信区间 [CI]，50.74 至 66.85，p = 0.0001）。EP 30C 对实验室确诊登革热的总体保护效果为 72.78%（95% CI，54.45 至 83.74，p = 0.0001）：在 MC 中，每 15,298 人中有 26 例登革热病例（每千人周 0.13 例），而在 CC 中，每 5,309 人中有 33 例登革热病例（每千人周 0.46 例）：使用 EP 30C 可在一定程度上预防可能的登革热和实验室确诊的登革热。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Homeopathy 医学-全科医学与补充医学

CiteScore

3.40

自引率

70.60%

发文量

审稿时长

20.1 weeks

期刊介绍： Homeopathy is an international peer-reviewed journal aimed at improving the fundamental understanding and clinical practice of homeopathy by publishing relevant high-quality original research articles, reviews, and case reports. It also promotes commentary and debate on matters of topical interest in homeopathy.