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Homeopathy at a Turning Point. 处于转折点的顺势疗法
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-20 DOI: 10.1055/s-0044-1789000
Andrea Dei
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引用次数: 0
Homeopathy, Acupuncture and Phytotherapy in the Veterinary Treatment or Prophylaxis of Diseases in Animals: An Overview of Systematic Reviews 顺势疗法、针灸和植物疗法在兽医治疗或预防动物疾病中的应用:系统综述
IF 1.7 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-16 DOI: 10.1055/s-0044-1788570
Edna Cristiane da Matta, Maristela Takeda, Nathalia Salles Scortegagna de Medeiros, Jorge Kioshi Hosomi, Leoni Villano Bonamin

Introduction Complementary and alternative veterinary medicine (CAVM) has been intensively used, and there is currently an increasing demand for a more rigorous approach regarding its clinical effectiveness.

Aims The objectives of this overview were: first, to identify systematic reviews on homeopathy, acupuncture and phytotherapy in veterinary medicine and assess their methodological quality; and second, to map interventions and findings in the treatment or prophylaxis of any medical conditions in any animal species for which high-quality systematic reviews had identified reliable evidence of efficacy or effectiveness in randomized controlled trials (RCTs) or controlled clinical trials (CCTs).

Method The study was an overview of systematic reviews published in the years 2000 to 2022 inclusive. The following databases were used: CAB Abstracts, PubMed and Vet Index, from which the abstracts of 173 articles were extracted, 22 of which were initially included for complete analysis. After excluding 15 studies according to the exclusion/inclusion criteria, 7 review papers were comprehensively analyzed. The review quality was assessed by the Measurement Tool to Assess Systematic Reviews (AMSTAR 2) method. The reported RCTs/CCTs in these reviews were analyzed for their reliability, and the results were classified according to statistical significance and risk of bias.

Results Seven eligible systematic reviews reported studies on dogs, horses, cats, cattle, sheep, goats, swine, rabbits and poultry. The number of primary RCTs/CCTs was 38 for homeopathy, 35 for acupuncture, and 171 for phytotherapy. The AMSTAR 2 evaluation ranked two reviews of veterinary homeopathy as high-quality, in which two placebo-controlled RCTs comprised reliable evidence, one of which reported efficacy of homeopathy as prophylaxis for diarrhea in pigs. The systematic reviews of acupuncture and phytotherapy were all of low quality, preventing formal assessment of their reviewed RCTs/CCTs.

Conclusion Only the systematic reviews of homeopathy were rated of sufficient quality to enable the assessment of reliable evidence within their reviewed RCTs. Contemporary high-quality systematic reviews of clinical trials in each of the three areas of CAVM are required.

引言 补充和替代兽医学(CAVM)已被广泛使用,目前对其临床有效性的更严格方法的需求日益增加。目的 本综述的目的是:首先,确定有关兽医学中顺势疗法、针灸和植物疗法的系统综述,并评估其方法学质量;其次,绘制在随机对照试验(RCT)或对照临床试验(CCT)中,高质量的系统综述确定了可靠的疗效或有效性证据的任何动物物种的任何病症的治疗或预防方面的干预措施和研究结果。研究方法 该研究对 2000 年至 2022 年(含 2022 年)发表的系统综述进行了概述。使用了以下数据库CAB Abstracts、PubMed 和 Vet Index,从中提取了 173 篇文章的摘要,并初步纳入了其中的 22 篇文章进行完整分析。根据排除/纳入标准排除了 15 项研究后,对 7 篇综述论文进行了全面分析。综述质量采用系统综述评估工具(AMSTAR 2)方法进行评估。对这些综述中报告的 RCT/CCT 进行了可靠性分析,并根据统计显著性和偏倚风险对结果进行了分类。结果 七篇符合条件的系统综述报告了关于狗、马、猫、牛、绵羊、山羊、猪、兔子和家禽的研究。顺势疗法的主要 RCT/CCT 为 38 项,针灸为 35 项,植物疗法为 171 项。AMSTAR 2评估将两篇兽医顺势疗法综述评为高质量,其中两篇安慰剂对照RCT研究提供了可靠的证据,其中一篇报告了顺势疗法作为猪腹泻预防疗法的疗效。针灸和植物疗法的系统综述质量均较低,因此无法对其综述的RCT/CCT进行正式评估。结论 只有顺势疗法的系统综述被评为具有足够的质量,可以对其受评 RCT 中的可靠证据进行评估。需要对 CAVM 三个领域中每个领域的临床试验进行当代高质量的系统综述。
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引用次数: 0
Pharmacoeconomic Study of Homeopathic Medicines: A Critical Appraisal of Methods and Conclusions Shows Serious Cause for Concern. 顺势疗法药物的药物经济学研究:对方法和结论的批判性评估显示出严重的担忧。
IF 1.7 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-09 DOI: 10.1055/s-0044-1788921
Angelina J Mosley
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引用次数: 0
Solvatochromic Dyes Track a Homeopathic Preparation through Water-Stream Systems in a Program to Control Tick Infestation at a Wild Animal Rehabilitation Center in Brazil 在巴西野生动物康复中心的一项控制蜱虫侵扰计划中,溶解变色染料通过水流系统跟踪顺势疗法制剂
IF 1.7 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-09 DOI: 10.1055/s-0044-1787783
Nathalia Salles Scortegagna de Medeiros, Andréia Adelaide G. Pinto, Sérgio Frana, Mônica Filomena Souza, Ivana Barbosa Suffredini, Steven John Cartwright, Leoni Villano Bonamin

Introduction In 2021, the area of CRAS (Centro de Reabilitação de Animais Selvagens – Wild Animal Rehabilitation Center), located in a state park in Campo Grande City, Mato Grosso do Sul, Brazil, was suffering from a tick infestation affecting wild animals that inhabit the area and humans that visited its trails. Following a formal technical–scientific cooperation agreement between IMASUL, an institute for the environment in Mato Grosso do Sul state, and SIGO Homeopatia, a formulated homeopathic complex (Formula Parques Urbanos, FPU) was designed and prepared specifically to treat the animals. This environmental intervention used specially designed slow-release water biodegradable devices. Tracking the FPU signal in water was necessary to monitor and manage the intervention.

Aims Our aims were (1) to evaluate, among six previously standardized solvatochromic dyes, which would serve as a marker for the homeopathic complex under study; and (2) to evaluate whether the chosen solvatochromic dye could map the propagation of the homeopathic complex activity throughout the stream system from water samples harvested at different locations over time.

Method Water samples were harvested from each point at different times, filtered, frozen, and sent to the laboratory, where they were prepared at 1cH potency for analysis using 30% ethanol as the vehicle. Solvatochromic dyes were used to analyze the samples since they alter their absorbance when in contact with homeopathic potencies. Of the six dyes tested, Coumarin 7 was found to be the most suitable for tracking the FPU complex. A static and average unidirectional magnetic field of 2,400 Gauss (240 mT), generated by a neodymium magnet, was applied to the samples immediately before reading.

Results There were significant differences in the delta absorbance of dyes when adding treated/potentized water samples, making it possible to map the propagation of the FPU signal throughout the park over time. The signals were identifiable at the same point 1 minute and 32 days after the insertion of the device into the water. These signals were also identifiable after 75 minutes and 8 days at a point far from the insertion place.

Conclusion Coumarin 7 was the best marker for the homeopathic complex (FPU) used to treat the wild animals living in the park. The microplates/enzyme-linked immunosorbent assay reader method and the application of a magnetic field to samples were shown to be effective in tracing homeopathic signals by changes in dye absorbance (p ≤ 0.02) in a real-life situation, with large volumes of water, involving many environmental variables, and over large distances.

导言 2021 年,位于巴西南马托格罗索州坎波格兰德市一个州立公园内的野生动物康复中心(CRAS)地区受到了蜱虫的侵扰,影响了栖息在该地区的野生动物和到访该地区小径的人类。南马托格罗索州环境研究所(IMASUL)与 SIGO Homeopatia 签署了正式的技术科学合作协议后,设计并制备了一种顺势疗法复方制剂(Formula Parques Urbanos,FPU),专门用于治疗动物。这种环境干预措施使用了专门设计的可在水中生物降解的缓释装置。跟踪水中的 FPU 信号对于监测和管理干预措施十分必要。目的 我们的目的是:(1)在之前标准化的六种溶解变色染料中,评估哪一种可以作为所研究的顺势疗法复合物的标记;(2)评估所选择的溶解变色染料是否可以通过在不同地点采集的水样,绘制出顺势疗法复合物活动在整个溪流系统中的传播图。方法 在不同时间从每个点采集水样,过滤、冷冻后送至实验室,以 30% 的乙醇为载体,按 1cH 的效价进行分析。由于溶变色染料在与顺势疗法药效接触时会改变吸光度,因此使用溶变色染料对样本进行分析。在测试的六种染料中,发现香豆素 7 最适合追踪 FPU 复合物。在读数前,立即对样品施加由钕磁铁产生的 2,400 高斯(240 mT)的静态平均单向磁场。结果 加入经处理/强效处理的水样时,染料的 delta 吸光度存在明显差异,因此可以绘制出 FPU 信号随时间在整个公园的传播图。在将装置放入水中 1 分钟后和 32 天后,可在同一点识别信号。在距离插入地点较远的地方,75 分钟后和 8 天后也能识别这些信号。结论 香豆素 7 是用于治疗公园野生动物的顺势疗法复合物(FPU)的最佳标记。微孔板/酶联免疫吸附测定读数器方法和对样品施加磁场的方法证明,在现实生活中,通过染料吸光度的变化(p ≤ 0.02)来追踪顺势疗法信号是有效的,因为水量大、环境变量多、距离远。
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引用次数: 0
Characterisation of Aqueous Ultra-high Homeopathic Potencies: Nanoparticle Tracking Analysis. 超高顺势疗法药效水剂的特性:纳米粒子跟踪分析。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-21 DOI: 10.1055/s-0044-1787782
Michel Van Wassenhoven, Martine Goyens, Pierre Dorfman, Philippe Devos, Jean-Louis Demangeat

Background and objectives:  Over the past decade, research using various methods has claimed the material nature, including nanoparticles (NPs), of high homeopathic potencies. The current study aims to verify these findings using NP tracking analysis (NTA).

Methods:  Six independent serial dilutions of commonly used homeopathic medicines-either soluble (Gelsemium, Pyrogenium, Kalium mur) or insoluble (Cuprum, Argentum, Silicea)-were prepared according to European Pharmacopoeia standards. We compared the homeopathic dynamisations (DYNs) in pure water with their potentised controls and with simple dilutions (DIL) up to 30cH/10-60. We also tested the influence of the container (glass or PET) on the solvent controls.

Results:  We observed the presence of particles from 20 to 300-400 nm in all DYNs, DILs and controls, except in pure unstirred water. The sizes and size distributions of NPs in high homeopathic potencies were smaller than those in controls for soluble sources and larger for insoluble sources, even above 11cH. The opposite behaviour was observed in the number of NPs. When comparing DYN and DIL, the number, size, presence of aggregates or chains and brightness of NPs increased with DYNs, which was also observed above 11cH. Many NPs scattered light of low intensity, indicating the presence of material particles. The container had a significant effect on the number and size of NPs, indicating the involvement of the atmosphere and leaching processes.

Conclusion:  Homeopathic medicines contain NPs with specific properties, even when diluted beyond Avogadro's number. Homeopathic potentisation is not a simple dilution. The starting material, the solvent used, the type of container and the manufacturing method influence the characteristics of these NPs. The nature of these NPs is not known, but most likely they are a mixture of nanobubbles and elements from the atmosphere and container, including insoluble ones.

背景和目的:在过去十年中,使用各种方法进行的研究证实了高顺势疗法效力的物质性质,包括纳米颗粒(NPs)。本研究旨在使用 NP 跟踪分析(NTA)验证这些发现:方法:根据欧洲药典标准制备了六种常用顺势疗法药物的独立系列稀释液--可溶的(Gelsemium、Pyrogenium、Kalium mur)或不溶的(Cuprum、Argentum、Silicea)。我们比较了纯净水中的顺势疗法药剂(DYN)与它们的强效对照药剂以及高达 30cH/10-60 的简单稀释液(DIL)。我们还测试了容器(玻璃或 PET)对溶剂对照的影响:我们在所有 DYNs、DILs 和对照品中观察到了从 20 纳米到 300-400 纳米的微粒,纯净水除外。对于可溶源,高顺势药效中 NPs 的尺寸和尺寸分布小于对照组,而对于不溶源,其尺寸和尺寸分布则大于对照组,甚至高于 11cH。在 NPs 的数量方面,观察到了相反的行为。在比较 DYN 和 DIL 时,NPs 的数量、大小、聚集体或链的存在以及亮度都随着 DYN 的增加而增加,这一点在 11cH 以上也能观察到。许多 NP 散射的光强度较低,表明存在物质颗粒。容器对 NPs 的数量和大小有显著影响,表明大气和浸出过程参与其中:顺势疗法药物含有具有特殊性质的 NPs,即使稀释度超过阿伏加德罗数也是如此。顺势疗法的强效化并非简单的稀释。起始材料、所用溶剂、容器类型和制造方法都会影响这些 NPs 的特性。这些 NPs 的性质尚不清楚,但很可能是纳米气泡与大气和容器中的元素(包括不溶性元素)的混合物。
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引用次数: 0
Exploring the Role of Homeopathic Intervention in Post-COVID Functional Gastrointestinal Disorders: A Case Series of 12 Patient Profiles. 探索顺势疗法干预在 COVID 后功能性胃肠功能紊乱中的作用:12 位患者的病例系列。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-05 DOI: 10.1055/s-0044-1787003
Hima Bindu Ponnam, Siva Subrahmanyam Chirravuri, Shanmukha Priya Konduru, Swathi Jammalamadaka

Background:  In the last 2 years of the pandemic, a wide range of cases of post-COVID functional gastrointestinal disorders (PC-FGIDs) has been reported.

Aim:  This case series aimed to investigate the role of homeopathic intervention in the treatment of PC-FGIDs.

Methods:  This is a retrospective analysis of the clinical data of individuals who had suffered from PC-FGIDs that were diagnosed based on clinical symptoms using the Gastrointestinal Symptoms Rating Scale (GSRS) and treated exclusively with individualized homeopathic medicines. Cases that had undergone regular monthly assessment using the GSRS and had a Post-COVID-19 Functional Status (PCFS) score for up to 3 months were considered.

Results:  Thirty cases were screened and twelve were included according to the study criteria. The mean age of seven women and five men was 36 years. GSRS and PCFS scores showed marked improvement in each of 10 cases within the 3-month treatment period.

Conclusion:  Homeopathic intervention proved beneficial in 10 of 12 patients with PC-FGIDs. The findings may help researchers plan future controlled clinical studies in this field.

背景:目的:本病例系列旨在研究顺势疗法干预在治疗PC-FGIDs中的作用:这是一项对PC-FGIDs患者临床数据的回顾性分析,根据临床症状使用胃肠道症状评分量表(GSRS)进行诊断,并完全采用个体化顺势疗法药物进行治疗。每月定期使用胃肠道症状量表(GSRS)对病例进行评估,并在 COVID-19 后对其功能状态(PCFS)进行长达 3 个月的评分:根据研究标准筛选出 30 个病例,其中 12 个病例被纳入研究范围。其中 7 名女性和 5 名男性的平均年龄为 36 岁。在 3 个月的治疗期内,10 个病例的 GSRS 和 PCFS 评分均有明显改善:结论:事实证明,顺势疗法干预对 12 例 PC-FGID 患者中的 10 例有益。结论:顺势疗法干预对 12 例 PC-FGID 患者中的 10 例均有疗效,这些发现可能有助于研究人员规划该领域未来的临床对照研究。
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引用次数: 0
The Three Powerful Traditions of Thinking that Constitute Homeopathy. 构成顺势疗法的三大强大思维传统。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-01 Epub Date: 2024-01-29 DOI: 10.1055/s-0043-1775814
Josef M Schmidt

By means of a historical, classical philological and philosophical approach, this paper attempts to demonstrate that homeopathy is based on three powerful traditions of thinking, which can be traced back to Ancient Greece's pre-Socratic era. Actually, it seems to be constituted by what may be termed lógos-, hómoion- and iásthai-thinking: that is, thinking in terms of rationality, similarity and healing. By contrast, modern medicine tends to be aligned with just one of these traditions, at the expense of the others, this being not without risk and adverse effects. It is mainly determined by the first type of rationality that genealogically derives from, and is therefore compatible with, the logic of economics whose predominance in the health care systems of modern societies is progressively rising. Homeopathy, however, may not be sufficiently and fairly understood without taking into account the complementary forms of thinking on which it also rests, such as the principle of similarity in an all-encompassing sense, and ancient healing knowledge in the tradition of catharsis. As a corollary of being essentially constituted by the three, homeopathy may persistently be in need of a dynamic equilibrium of its three constituent bases. Attempts to approach homeopathy from only one of the indicated modes of thinking fail to grasp its essence and result in figments or caricatures of what homeopathy was originally meant to be.

本文试图通过历史学、古典语言学和哲学的方法,证明顺势疗法建立在三种强大的思维传统之上,而这三种思维传统可以追溯到古希腊的前苏格拉底时代。实际上,顺势疗法似乎是由所谓的 "lógos-思维"、"hómoion-思维 "和 "iásthai-思维 "构成的:即从理性、相似性和治疗的角度进行思考。相比之下,现代医学往往只与其中一种传统保持一致,而牺牲了其他传统,这并非没有风险和不利影响。它主要是由第一种理性决定的,这种理性在谱系上源于经济学逻辑,因此与经济学逻辑相一致,而经济学逻辑在现代社会医疗保健系统中的主导地位正在逐步上升。然而,如果不考虑顺势疗法所依赖的互补思维形式,如包罗万象的相似性原则和宣泄传统中的古代治疗知识,就无法充分、公正地理解顺势疗法。顺势疗法本质上是由三者构成的,因此它可能始终需要三个构成基础的动态平衡。试图只从上述思维模式中的一种切入顺势疗法,无法抓住其本质,结果只能是对顺势疗法本来面目的臆造或讽刺。
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引用次数: 0
Unveiling the Patient Tapestry: Harnessing the Importance of Patient Perspectives in Advancing Homeopathy Research. 揭开病人的挂毯:利用病人观点在推进顺势疗法研究中的重要性。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-01 Epub Date: 2023-12-04 DOI: 10.1055/s-0043-1775995
Abhijit Dutta
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引用次数: 0
Probabilistic Reasoning in Homeopathy Practice and its Implications for Clinical Research. 顺势疗法实践中的概率推理及其对临床研究的启示。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-01 Epub Date: 2023-10-31 DOI: 10.1055/s-0043-1775993
Fabrice Sébastien Berna, Jean-Lionel Bagot

The principle of similitude put forward by Hahnemann has challenging practical consequences in the selection of the right homeopathic medicine for a patient. According to this principle, only the medicines that best fit the totality of the symptoms of a given patient are supposed to really cure: this greatly depends on the homeopath's clinical analysis. In addition, a patient's illness may be more or less curable, depending on the characteristics of the disease. In their daily practice, homeopaths typically apply Bayesian reasoning to deal with uncertainty associated with both medicine and disease. We suggest that clinical research on homeopathy would gain by integrating this kind of prior estimation of (1) the probability of a given medicine being effective for that particular patient and (2) the probability of the patient's disease (or symptoms) being curable. We therefore suggest that future trials of N-of-1 design may gain (1) by testing a small number of "best candidate" medicines (instead of one) for a given patient facing a given disease, and (2) by including careful prior estimations of the probabilities that (a) each selected medicine will be efficient for that patient and (b) the patient's disease will be reversible with the medicine.

Hahnemann提出的相似原理在为患者选择正确的顺势疗法药物方面具有挑战性的实际后果。根据这一原则,只有最适合特定患者整体症状的药物才能真正治愈:这在很大程度上取决于顺势疗法的临床分析。此外,根据疾病的特点,患者的疾病可能或多或少是可以治愈的。在日常实践中,顺势疗法者通常应用贝叶斯推理来处理与医学和疾病相关的不确定性。我们认为,顺势疗法的临床研究将通过整合(1)给定药物对特定患者有效的概率和(2)患者疾病(或症状)可治愈的概率的这种先验估计来获得益处。因此,我们建议,未来的N选1设计试验可能会获得(1)通过为面临特定疾病的特定患者测试少量“最佳候选”药物(而不是一种),以及(2)通过仔细预先估计(a)每种选择的药物对该患者有效,以及(b)患者的疾病与该药物可逆的概率。
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引用次数: 0
Homeopathic Sulphur Ointment as Adjuvant in the Treatment of Sheep with Myiasis by Cochliomyia hominivorax (Diptera: Calliphoridae): A Case Series. 顺势疗法硫软膏辅助治疗人型Cochlomyia humanivorax(直翅目:丽蝇科)绵羊麦虫病:病例系列。
IF 1.2 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-01 Epub Date: 2023-09-27 DOI: 10.1055/s-0043-1770360
Giuliano Pereira de Barros, Denise Pereira Leme, Laura Livia Arias Avilés, Patrizia Ana Bricarello

Background:  Myiasis by Cochliomyia hominivorax (Diptera: Calliphoridae) is a serious problem in animal health. Homeopathic Sulphur presents similarity with the clinical presentation verified in these cases and has already shown in vitro efficacy on the blowfly that causes this pathology. This article presents the report of a series of clinical cases of myiasis by C. hominivorax in sheep that underwent adjuvant treatment with homeopathic Sulphur and presents a theoretical-scientific discussion of biological events related to the clinical treatment of the condition.

Patients:  Seven naturally occurring myiases affecting sheep from an experimental farm were treated by an ointment impregnated with the homeopathic medicine Sulph 12cH, used as adjuvant after the manual removal of accessible larvae from the wound during wound cleaning. The animals were treated daily and evaluated clinically until complete healing of the lesions. Clinical information on the evolution of the inflammatory and scarring process was collected. Blood counts and bacteriological examinations were performed before and after topical homeopathic treatment.

Results:  The homeopathic ointment Sulph 12cH was able to inhibit the development of parasitic C. hominivorax larvae and promote tissue repair and healing in naturally occurring myiasis in the sheep of this study.

Conclusion:  The homeopathic medicine Sulphur, formulated as an ointment, may be a useful new and adjuvant therapeutic option for treating myiasis in animals.

背景: 人型钩虫病是一个严重的动物健康问题。顺势疗法硫与这些病例中验证的临床表现相似,并且已经在体外对导致这种病理的苍蝇显示出疗效。本文报告了一系列人源性念珠菌在绵羊身上感染蝇蛆病的临床病例,这些病例接受了顺势疗法硫的辅助治疗,并对与该疾病临床治疗相关的生物学事件进行了理论科学讨论。患者: 来自一个实验农场的七种影响绵羊的自然发生的粘虫通过一种浸有顺势疗法药物硫12cH的软膏进行治疗,该软膏在伤口清洁过程中从伤口手动取出可接触的幼虫后用作佐剂。每天对动物进行治疗并进行临床评估,直到病变完全愈合。收集有关炎症和瘢痕形成过程演变的临床信息。在局部顺势疗法治疗前后进行血液计数和细菌检查。结果: 在本研究的绵羊中,顺势疗法软膏硫12cH能够抑制寄生的人身线虫幼虫的发育,并促进自然发生的蝇蛆病的组织修复和愈合。结论: 顺势疗法药物硫,以软膏的形式配制,可能是治疗动物蝇蛆病的一种有用的新的辅助治疗选择。
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引用次数: 0
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