Seasonality and Co-Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness—Valencia Region, Spain, 2010–2021

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2024-10-22 DOI:10.1111/irv.70017

George Shirreff, Sandra S. Chaves, Laurent Coudeville, Beatriz Mengual-Chuliá, Ainara Mira-Iglesias, Joan Puig-Barberà, Alejandro Orrico-Sanchez, Javier Díez-Domingo, Valencia Hospital Surveillance Network for the Study of Influenza and Other Respiratory Viruses (VAHNSI), Lulla Opatowski, F. Xavier Lopez-Labrador

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Abstract

Background

Respiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co-circulation and interaction between viruses is critical to prevention and management. We use > 10-year active surveillance in the Valencia Region to assess seasonality and co-circulation.

Methods

Over 2010–2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real-time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS-CoV-2 and non-SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co-detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation.

Results

Most viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December–February, as did HCoV and SARS-CoV-2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co-infection. Multiple viruses were found in 4% of patients, with more common co-detection in children under 5 (9%) than older ages. Influenza co-detection was generally observed infrequently relative to expectation, while RSV co-detections were more common, particularly among young children.

Conclusions

We identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co-detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co-detection, meriting further study.

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2010-2021 年西班牙巴伦西亚地区急性呼吸道疾病住院患者呼吸道病毒感染的季节性和共同检测。

背景：众所周知，呼吸道病毒是冬季的高负担，但人们对许多病毒的季节性仍然知之甚少。更好地了解病毒之间的共同传播和相互作用对预防和管理至关重要。我们利用巴伦西亚地区 > 10 年的主动监测来评估季节性和共同传播：2010-2021 年间，我们使用多重实时 PCR 分析了急性呼吸道疾病住院患者的样本，以检测 9 种病毒：流感、呼吸道合胞病毒 (RSV)、副流感病毒 (PIV)、犀牛/肠道病毒 (HRV/ENV)、偏肺病毒 (MPV)、博卡病毒、腺病毒、SARS-CoV-2 和非 SARS 冠状病毒 (HCoV)。对冬季发病率的季节性模式进行了研究。分析了一个样本中同时检测到多种病毒的情况，并与独立循环粗略模型下的预期值进行了比较：结果：大多数病毒在不同年份表现出一致的模式。具体来说，RSV 和流感的季节性很明确，在 12 月至 2 月达到高峰，HCoV 和 SARS-CoV-2 也是如此。MPV、PIV和HRV/ENV的季节性不明显，它们的流行超出了观察期。所有病毒都在 1 月份流行，这表明任何一对病毒都有机会合并感染。在 4% 的患者中发现了多种病毒，5 岁以下儿童（9%）的共同检测率高于年龄较大者。与预期的情况相比，流感病毒的合并感染率较低，而 RSV 的合并感染率较高，尤其是在幼儿中：我们发现了冬季与急性呼吸道住院相关病毒的特征模式。结论：我们发现了与冬季急性呼吸道疾病住院相关的病毒的特征模式，同时循环允许广泛的病毒联合检测，尤其是在幼儿中。不过，病毒组合的共同检测率似乎有所不同，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.