Behavioral and neurophysiological signatures of cognitive control in humans and rats.

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY International Journal of Neuropsychopharmacology Pub Date : 2024-11-01 DOI:10.1093/ijnp/pyae050
Samantha R Linton, Ty Lees, Ann Iturra-Mena, Brian D Kangas, Genevieve Nowicki, Rachel Lobien, Gordana Vitaliano, Jack Bergman, William A Carlezon, Diego A Pizzagalli
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Abstract

Background: Deficits in cognitive control are implicated in numerous neuropsychiatric disorders. However, relevant pharmacological treatments are limited, likely due to weak translational validity of applicable preclinical models used. Neural indices derived from electroencephalography may prove useful in comparing and translating the effects of cognition-enhancing drugs between species. In the current study, we aimed to extend our previous cross-species results by examining if methylphenidate (MPH) modulates behavioral and neural indices of cognitive control in independent cohorts of humans and rats.

Methods: We measured continuous electroencephalography data from healthy adults (n = 25; 14 female) and Long Evans rats (n = 22; 8 female) and compared both stimulus- and response-locked event-related potentials and spectral power measures across species, and their MPH-related moderation following treatment with vehicle (placebo) or 1 of 2 doses of MPH.

Results: Across both species, linear mixed effects modeling confirmed the expected Flanker interference effect on behavior (eg, accuracy) and response-related event-related potentials. Unexpectedly, in contrast to past work, we did not observe any task-related effects on the spectral power of rodents. Moreover, MPH generally did not modulate cognitive control of either species, although some species-specific patterns offer insight for future research.

Conclusions: Collectively, these findings in independent human and rodent subjects replicate some of our previously reported behavioral and neurophysiological patterns partly consistent with the notion that similar neural mechanisms may regulate cognitive control in both species. Nonetheless, these results showcase an approach to accelerate translation using a coordinated between-species platform to evaluate pro-cognitive treatments.

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人类和大鼠认知控制的行为和神经生理学特征
背景:许多神经精神疾病都与认知控制缺陷有关。然而,相关的药物治疗却很有限,这可能是由于适用的临床前模型的转化有效性较弱。脑电图(EEG)得出的神经指数可能有助于比较和转化不同物种间认知增强药物的效果。在目前的研究中,我们旨在通过研究哌醋甲酯(MPH)是否会调节人类和大鼠独立群体的认知控制行为和神经指数,从而扩展我们之前的跨物种研究结果:我们测量了健康成年人(n=25;14只雌性)和Long Evans大鼠(n=22;8只雌性)的连续脑电图数据,并比较了不同物种的刺激和反应锁定事件相关电位(ERPs)和频谱功率测量,以及它们在接受药物(安慰剂)或两种剂量之一的MPH治疗后与MPH相关的调节作用:在两个物种中,线性混合效应模型证实了预期的Flanker干扰对行为(如准确性)和反应相关ERPs的影响。出乎意料的是,与过去的研究不同,我们没有观察到啮齿动物的频谱功率受到任何任务相关的影响。此外,虽然某些物种的特定模式为未来研究提供了启示,但 MPH 一般不会调节这两种动物的认知控制:总之,这些在独立的人类和啮齿动物受试者身上得到的研究结果复制了我们之前报道的一些行为和神经生理学模式,部分符合两种动物中类似的神经机制可能调节认知控制的观点。尽管如此,这些结果展示了一种利用物种间协调平台加速转化的方法,以评估有利于认知的治疗方法。
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来源期刊
CiteScore
8.40
自引率
2.10%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.
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