The Influence of Anthropometric Factors on Renal mpMRI: Insights From Regional Analysis

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Magnetic Resonance Imaging Pub Date : 2024-10-28 DOI:10.1002/jmri.29638

Luis Carlos Sanmiguel Serpa MSc, Pieter de Visschere MD, PhD, Marijn Speeckaert MD, PhD, Pim Pullens PhD

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Abstract

Background

Multiparametric MRI (mpMRI) provides detailed insights into renal function, but the impact of anthropometric factors on renal imaging is not fully understood.

Purpose

To investigate regional correlations between mpMRI parameters and age, body mass index (BMI), and body surface area (BSA).

Study Type

Prospective, cross-sectional observational study.

Population

Twenty-nine healthy volunteers (44.5 ± 18.3 years, 18 females) without a history of renal disease.

Field Strength/Sequence

3-T, pseudo-continuous arterial spin labeling, multi-echo gradient-recalled echo, diffusion-weighted imaging, T₁ and T₂ mapping.

Assessment

Bilateral kidneys were segmented into nine concentric layers (outer cortex to inner regions) and nine equiangular sections (lower to upper pole). Key parameters (renal blood flow [RBF], $R_{2}^{*}$ , apparent diffusion coefficient [ADC], T₁ and T₂ maps) were correlated with age, BMI, and BSA. Differences in parameters between age and BMI groups were also evaluated.

Statistical Tests

Spearman correlation, Mann–Whitney U test, and rank-biserial correlation coefficient for effect size. A P-value <0.05 was considered statistically significant.

Results

RBF correlated negatively with age in all regions and BMI in inner layers and lower pole. ADC negatively correlated with BMI (significance was not reached in layers 2, 7, 8; P-value = 0.06–0.12) and BSA in layers 1–7. T₁ negatively correlated with age in inner regions and lower medial pole. Significant positive correlations were found between age and $R_{2}^{*}$ (outermost layer, upper pole), age and T₂ (inner and cranial-caudal regions), as well as BMI and T₂ (except upper pole; P-value = 0.06). Significant differences between age groups were observed for RBF (all regions), $R_{2}^{*}$ (outermost and second innermost layers, central lateral region), T₁ (innermost layer), and T₂ (upper medial pole). Between BMI groups, ADC (middle layers, upper medial pole) and T₂ (outermost and inner layers, lower pole to lateral region) differed significantly.

Data Conclusion

Intrarenal variance of mpMRI parameters correlated with age, BMI, and BSA.

Evidence Level

Technical Efficacy

Stage 1

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人体测量因素对肾脏 mpMRI 的影响：区域分析的启示

背景：目的：研究多参数磁共振成像（mpMRI）参数与年龄、体重指数（BMI）和体表面积（BSA）之间的区域相关性：研究类型：前瞻性横断面观察研究：29 名健康志愿者（44.5 ± 18.3 岁，18 名女性），无肾病史：3-T、假连续动脉自旋标记、多回波梯度唤回回波、弥散加权成像、T1 和 T2 映射：双侧肾脏被分割成九个同心层（外侧皮质到内侧区域）和九个等角切片（下极到上极）。主要参数（肾血流量 [RBF]、R 2 * $$ {R}_2^{\ast } $$、表观弥散系数 (apparent diffusion coefficient)$$ 、表观扩散系数 [ADC]、T1 和 T2 图）与年龄、体重指数和体重指数相关。还评估了年龄组和 BMI 组之间的参数差异：斯皮尔曼相关性、曼-惠特尼 U 检验和效应大小的秩-阶相关系数。A P 值结果所有区域的 RBF 与年龄呈负相关，内层和下极的 RBF 与 BMI 呈负相关。ADC 与体重指数负相关（在第 2、7、8 层未达到显著性；P 值 = 0.06-0.12），在第 1-7 层与 BSA 负相关。内层和内侧下极的 T1 与年龄呈负相关。年龄与 R 2 * $$ {R}_2^{\ast } 之间呈显著正相关。$$（最外层、上极）、年龄与 T2（内侧和头颅-尾椎区域）以及体重指数与 T2（上极除外；P 值 = 0.06）之间存在显著正相关。在 RBF（所有区域）、R 2 * $$ {R}_2^{\ast } $$（最外层和第二层）、R 2 * $$ {R}_2^{\ast }$$（最外层和第二最内层、中央外侧区域）、T1（最内层）和 T2（内侧上极）。在 BMI 组之间，ADC（中层，上内侧极）和 T2（最外层和内层，下极至外侧区域）差异显著：数据结论：mpMRI 参数的肾小管内差异与年龄、体重指数和 BSA 相关。

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.