The Influence of Anthropometric Factors on Renal mpMRI: Insights From Regional Analysis.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-28 DOI:10.1002/jmri.29638

Luis Carlos Sanmiguel Serpa, Pieter de Visschere, Marijn Speeckaert, Pim Pullens

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Abstract

Background: Multiparametric MRI (mpMRI) provides detailed insights into renal function, but the impact of anthropometric factors on renal imaging is not fully understood.

Purpose: To investigate regional correlations between mpMRI parameters and age, body mass index (BMI), and body surface area (BSA).

Study type: Prospective, cross-sectional observational study.

Population: Twenty-nine healthy volunteers (44.5 ± 18.3 years, 18 females) without a history of renal disease.

Field strength/sequence: 3-T, pseudo-continuous arterial spin labeling, multi-echo gradient-recalled echo, diffusion-weighted imaging, T₁ and T₂ mapping.

Assessment: Bilateral kidneys were segmented into nine concentric layers (outer cortex to inner regions) and nine equiangular sections (lower to upper pole). Key parameters (renal blood flow [RBF], $R_{2}^{*}$ , apparent diffusion coefficient [ADC], T₁ and T₂ maps) were correlated with age, BMI, and BSA. Differences in parameters between age and BMI groups were also evaluated.

Statistical tests: Spearman correlation, Mann-Whitney U test, and rank-biserial correlation coefficient for effect size. A P-value <0.05 was considered statistically significant.

Results: RBF correlated negatively with age in all regions and BMI in inner layers and lower pole. ADC negatively correlated with BMI (significance was not reached in layers 2, 7, 8; P-value = 0.06-0.12) and BSA in layers 1-7. T₁ negatively correlated with age in inner regions and lower medial pole. Significant positive correlations were found between age and $R_{2}^{*}$ (outermost layer, upper pole), age and T₂ (inner and cranial-caudal regions), as well as BMI and T₂ (except upper pole; P-value = 0.06). Significant differences between age groups were observed for RBF (all regions), $R_{2}^{*}$ (outermost and second innermost layers, central lateral region), T₁ (innermost layer), and T₂ (upper medial pole). Between BMI groups, ADC (middle layers, upper medial pole) and T₂ (outermost and inner layers, lower pole to lateral region) differed significantly.

Data conclusion: Intrarenal variance of mpMRI parameters correlated with age, BMI, and BSA.

Evidence level: 4 TECHNICAL EFFICACY: Stage 1.

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人体测量因素对肾脏 mpMRI 的影响：区域分析的启示

背景：目的：研究多参数磁共振成像（mpMRI）参数与年龄、体重指数（BMI）和体表面积（BSA）之间的区域相关性：研究类型：前瞻性横断面观察研究：29 名健康志愿者（44.5 ± 18.3 岁，18 名女性），无肾病史：3-T、假连续动脉自旋标记、多回波梯度唤回回波、弥散加权成像、T1 和 T2 映射：双侧肾脏被分割成九个同心层（外侧皮质到内侧区域）和九个等角切片（下极到上极）。主要参数（肾血流量 [RBF]、R 2 * $$ {R}_2^{\ast } $$、表观弥散系数 (apparent diffusion coefficient)$$ 、表观扩散系数 [ADC]、T1 和 T2 图）与年龄、体重指数和体重指数相关。还评估了年龄组和 BMI 组之间的参数差异：斯皮尔曼相关性、曼-惠特尼 U 检验和效应大小的秩-阶相关系数。A P 值结果所有区域的 RBF 与年龄呈负相关，内层和下极的 RBF 与 BMI 呈负相关。ADC 与体重指数负相关（在第 2、7、8 层未达到显著性；P 值 = 0.06-0.12），在第 1-7 层与 BSA 负相关。内层和内侧下极的 T1 与年龄呈负相关。年龄与 R 2 * $$ {R}_2^{\ast } 之间呈显著正相关。$$（最外层、上极）、年龄与 T2（内侧和头颅-尾椎区域）以及体重指数与 T2（上极除外；P 值 = 0.06）之间存在显著正相关。在 RBF（所有区域）、R 2 * $$ {R}_2^{\ast } $$（最外层和第二层）、R 2 * $$ {R}_2^{\ast }$$（最外层和第二最内层、中央外侧区域）、T1（最内层）和 T2（内侧上极）。在 BMI 组之间，ADC（中层，上内侧极）和 T2（最外层和内层，下极至外侧区域）差异显著：数据结论：mpMRI 参数的肾小管内差异与年龄、体重指数和 BSA 相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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