The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Inherited Metabolic Disease Pub Date : 2024-10-26 DOI:10.1002/jimd.12801
Candelas Gross-Valle, Tessa C Jacobs, Janneke D A Dijck-Brouwer, Janniek Lubberts, Barbara M Bakker, Stephan J L Bakker, Yvonne van der Veen, Andrea B Schreuder, Terry G J Derks, Jennifer van der Krogt, Joost Groen, M Rebecca Heiner-Fokkema
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Abstract

The urinary metabolite tetraglucoside (Glc4) is a potential biomarker for hepatic glycogen storage diseases (GSDs). Glc4 is believed to reflect body glycogen content and/or turnover. However, dietary polysaccharide intake may influence Glc4 excretion, potentially limiting the utility of Glc4 as a monitoring biomarker in hepatic GSDs. We aimed to investigate the association of dietary polysaccharide intake with Glc4 excretion. Urinary Glc4 excretion (mmol/mmol creatinine and mmol/24 h) was analyzed using a validated LC-MS/MS method. Data was analyzed from 65 kidney transplant recipients and 58 healthy kidney donors in the TransplantLines cohort study. Spearman's correlation and multivariable linear regression analyses were performed. In the multivariable analysis, dry lean body mass (DLBM), dietary polysaccharide intake, transplantation status, age, sex, and glycated hemoglobin (HbA1c) served as independent variables. Daily variation was examined in 21 healthy individuals of urinary Glc4 excretion in 2-h collections over a 24-h period. Mixed generalized additive models were built to study the association of prior polysaccharide intake with Glc4 excretion. No (univariate) associations were found between polysaccharide intake and Glc4 excretion. However, a significant interaction between DLBM and polysaccharide on 24 h Glc4 excretion was observed in the multivariate analysis. Glc4 excretion throughout the day exhibited no relationship to prior polysaccharide intake. Our findings suggest an indirect effect of polysaccharide intake on Glc4 excretion, potentially due to changes in muscle glycogen content and/or turnover. We have found no evidence that dietary polysaccharides under normal intakes increase urinary Glc4 directly.

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膳食多糖摄入量与尿液中四葡糖苷排泄量之间的关系
尿液代谢物四葡糖苷(Glc4)是肝糖原贮积症(GSD)的潜在生物标志物。Glc4 被认为能反映体内糖原的含量和/或周转率。然而,膳食多糖摄入量可能会影响 Glc4 的排泄,从而可能限制 Glc4 作为肝糖原贮积症监测生物标志物的效用。我们旨在研究膳食多糖摄入量与 Glc4 排泄的关系。我们采用经过验证的 LC-MS/MS 方法分析了尿液中 Glc4 的排泄量(毫摩尔/毫摩尔肌酐和毫摩尔/24 小时)。在 TransplantLines 队列研究中,对 65 名肾移植受者和 58 名健康肾脏捐献者的数据进行了分析。进行了斯皮尔曼相关分析和多变量线性回归分析。在多变量分析中,干瘦体重(DLBM)、膳食多糖摄入量、移植状态、年龄、性别和糖化血红蛋白(HbA1c)是自变量。研究人员检测了 21 名健康人在 24 小时内 2 小时尿液中 Glc4 排泄量的日变化。建立了混合广义相加模型来研究先前多糖摄入量与 Glc4 排泄量之间的关系。结果发现,多糖摄入量与 Glc4 排泄量之间没有(单变量)关联。然而,在多变量分析中发现,DLBM 和多糖对 24 小时 Glc4 排泄有明显的交互作用。全天的 Glc4 排泄与之前的多糖摄入量没有关系。我们的研究结果表明,多糖摄入对 Glc4 排泄有间接影响,这可能是由于肌糖原含量和/或周转率的变化造成的。我们没有发现正常摄入量下膳食多糖会直接增加尿液中 Glc4 的证据。
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来源期刊
Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease 医学-内分泌学与代谢
CiteScore
9.50
自引率
7.10%
发文量
117
审稿时长
4-8 weeks
期刊介绍: The Journal of Inherited Metabolic Disease (JIMD) is the official journal of the Society for the Study of Inborn Errors of Metabolism (SSIEM). By enhancing communication between workers in the field throughout the world, the JIMD aims to improve the management and understanding of inherited metabolic disorders. It publishes results of original research and new or important observations pertaining to any aspect of inherited metabolic disease in humans and higher animals. This includes clinical (medical, dental and veterinary), biochemical, genetic (including cytogenetic, molecular and population genetic), experimental (including cell biological), methodological, theoretical, epidemiological, ethical and counselling aspects. The JIMD also reviews important new developments or controversial issues relating to metabolic disorders and publishes reviews and short reports arising from the Society''s annual symposia. A distinction is made between peer-reviewed scientific material that is selected because of its significance for other professionals in the field and non-peer- reviewed material that aims to be important, controversial, interesting or entertaining (“Extras”).
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