Rapid Effects of MDMA Administration on Self-Reported Personality Traits and Affect State: A Randomized, Placebo-Controlled Trial in Healthy Adults.

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of psychoactive drugs Pub Date : 2024-10-23 DOI:10.1080/02791072.2024.2420044
Jessica L Maples-Keller, Courtland S Hyatt, Nathaniel L Phillips, Brinkley M Sharpe, Andrew Sherrill, Carly Yasinski, Collin Reiff, Jeffrey Rakofsky, Sheila A M Rauch, Boadie W Dunlop, Barbara O Rothbaum
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Abstract

3,4-methylenedioxymethamphetamine (MDMA) assisted therapy has been shown to be a safe and effective treatment for PTSD and emerging research suggests a change in personality traits may be a factor in treatment response. Most prior research on MDMA and personality has focused on cross-sectional comparisons of MDMA users and non-users; as such, well-controlled research assessing personality and affective states change following MDMA vs placebo administration is needed. In the current pre-registered study, we investigated the impact of MDMA administration on five-factor model (FFM) traits and affective states before and 48 h after drug administration in a randomized, placebo-controlled study of healthy adults (N = 34). Statistical significance was not observed for the four a priori hypotheses; however, medium effect sizes were found between MDMA administration and trait Openness and Positive Affect 48 h following drug administration, compared to placebo (d = .79 and .51, respectively). This study provides initial results to help guide future well-powered studies with large samples and longer follow-up timepoints to continue to investigate how MDMA impacts personality and emotional experience, which may inform optimization of MDMA treatment approaches.

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服用摇头丸对自述人格特质和情感状态的快速影响:健康成年人的随机安慰剂对照试验》。
3,4-亚甲二氧基甲基苯丙胺(MDMA)辅助疗法已被证明是一种安全有效的创伤后应激障碍治疗方法,而新的研究表明,人格特征的变化可能是影响治疗反应的一个因素。之前有关摇头丸和人格的研究大多集中在摇头丸使用者和非使用者的横截面比较上;因此,需要对摇头丸与安慰剂服用后的人格和情感状态变化进行良好控制的评估研究。在目前这项预先登记的研究中,我们对健康成年人(34 人)进行了一项随机、安慰剂对照研究,调查了服药前和服药后 48 小时内服用摇头丸对五因素模型(FFM)特征和情感状态的影响。四项先验假设均未发现统计学意义;但与安慰剂相比,服药后 48 小时,MDMA 与特质开放性和积极情感之间发现了中等效应大小(d = .79 和 .51)。这项研究提供了初步结果,有助于指导今后进行大样本和更长随访时间点的强效研究,以继续研究摇头丸如何影响人格和情绪体验,从而为优化摇头丸治疗方法提供信息。
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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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