Blackcurrant Anthocyanins Attenuate Estrogen -Deficiency-Induced Bone Loss through Modulating Microbial-Derived Short-Chain Carboxylic Acids and Phytoestrogen Metabolites in Peri- and Early Postmenopausal Women.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Metabolites Pub Date : 2024-10-11 DOI:10.3390/metabo14100541

Briana M Nosal, Staci N Thornton, Alexey V Melnik, Ali Lotfi, Manije Darooghegi Mofrad, Alexander Aksenov, Elaine Choung-Hee Lee, Ock K Chun

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Abstract

Objectives: The present study aimed to assess the effects of blackcurrant (BC) anthocyanins on concentrations of microbial-derived short-chain carboxylic acids (SCCAs) and metabolites of phytoestrogens. We then examined their associations with six-month changes in whole-body bone mineral density (BMD) and biomarkers of bone metabolism.

Methods: Fecal and blood samples from a pilot randomized controlled trial were collected and analyzed from 37 eligible peri- and early postmenopausal women aged 45-60 years who were randomized into one of three treatment groups consuming one placebo capsule (control), 392 mg BC (low BC) or 784 mg BC (high BC) daily for six months.

Results: Significant differences were observed between groups at baseline in acetic, propionic, valeric, caproic and heptanoic acids (p < 0.05). Isobutyric acid significantly decreased from baseline (0 months) to six months in the control group (p < 0.05) and the high BC group had a significantly greater concentration than the control group at six months (p < 0.05). Butyric acid was significantly greater in the high BC group than low BC at six months (p < 0.05). Six-month changes in caproic and isobutyric acids showed weak correlations with changes in whole-body BMD (r = 0.3519, p < 0.05 and r = 0.3465, p < 0.05, respectively). Isovaleric and valeric acids displayed weak correlations with BALP (r = 0.3361, p < 0.05) and OPG (r = 0.3593, p < 0.05), respectively. Enterodiol was positively correlated with BALP (r = 0.6056, p < 0.01) while enterolactone was positively correlated with osteocalcin (r = 0.5902, p < 0.001) and negatively correlated with sclerostin (r = -0.3485, p < 0.05).

Conclusions: The results suggest that BC may be a potential dietary agent to reduce postmenopausal bone loss through modulating microbially-derived SCCAs and phytoestrogen metabolites.

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黑加仑花青素通过调节微生物衍生的短链羧酸和植物雌激素代谢物，减轻围绝经期和绝经后早期妇女因雌激素缺乏引起的骨质流失。

研究目的本研究旨在评估黑加仑（BC）花青素对微生物衍生的短链羧酸（SCCA）和植物雌激素代谢物浓度的影响。然后，我们研究了它们与六个月内全身骨矿物质密度（BMD）和骨代谢生物标志物变化的关系：我们收集并分析了 37 名符合条件的 45-60 岁围绝经期和绝经后早期妇女的粪便和血液样本，这些妇女被随机分为三个治疗组，分别每天服用一粒安慰剂胶囊（对照组）、392 毫克 BC（低 BC）或 784 毫克 BC（高 BC），为期六个月：观察到各组之间在醋酸、丙酸、戊酸、己酸和庚酸的基线值上存在显著差异（P < 0.05）。对照组的异丁酸从基线（0 个月）到 6 个月明显减少（p < 0.05），高 BC 组在 6 个月时的浓度明显高于对照组（p < 0.05）。六个月时，高 BC 组的丁酸含量明显高于低 BC 组（p < 0.05）。己酸和异丁酸的六个月变化与全身 BMD 的变化呈弱相关性（分别为 r = 0.3519，p < 0.05 和 r = 0.3465，p < 0.05）。异戊酸和戊酸分别与 BALP（r = 0.3361，p < 0.05）和 OPG（r = 0.3593，p < 0.05）呈弱相关性。肠二醇与 BALP 呈正相关（r = 0.6056，p < 0.01），而肠内酯与骨钙素呈正相关（r = 0.5902，p < 0.001），与硬骨素呈负相关（r = -0.3485，p < 0.05）：结果表明，通过调节微生物衍生的短链氯化石蜡和植物雌激素代谢物，碱性生物碱可能是一种减少绝经后骨质流失的潜在膳食制剂。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.