Salivary Metabolites in Breast Cancer and Fibroadenomas: Focus on Menopausal Status and BMI.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Metabolites Pub Date : 2024-09-30 DOI:10.3390/metabo14100531

Elena I Dyachenko, Lyudmila V Bel'skaya

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Abstract

This study of the features of the biochemical composition of biological fluids in patients with breast cancer, including saliva, allows us to identify some indicators as metabolic predictors of the presence of the disease.

Objectives: to study the influence of the menopause factor and body mass index (BMI) on the biochemical composition of saliva and to evaluate the applicability of metabolic markers of saliva for the diagnosis of breast cancer.

Methods: The case-control study involved 1438 people (breast cancer, n = 543; fibroadenomas, n = 597; control, n = 298). A comprehensive study of the biochemical composition of saliva was carried out using 36 parameters.

Results: When comparing the salivary biochemical composition in breast cancer, fibroadenomas, and controls, it is necessary to take into account the menopausal status, as well as BMI (less than 25 or more) for the group of patients with preserved menstrual function. A complex of biochemical parameters has been identified that change in saliva during breast cancer, regardless of menopause and BMI (total protein, urea, uric acid, NO, α-amino acids, GGT), as well as specific parameters that must be taken into account when analyzing individual subgroups (imidazole compounds, LDH, catalase, α-amylase). During the study of a separate group of patients with leaf-shaped (phyllodes) tumors, we found similarities with breast cancer in the changes in some biochemical parameters that can be attributed to metabolites of malignant growth (protein, α-amino acids, calcium, NO, pyruvate, peroxidase, α-amylase).

Conclusions: We demonstrated changes in a wide range of salivary biochemical parameters depending on the presence of fibroadenomas and breast cancer. From the point of view of clinical practice, this may be useful information for monitoring the condition of patients with fibroadenomas, which are difficult to unambiguously classify based on instrumental diagnostics alone.

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乳腺癌和纤维腺瘤中的唾液代谢物：关注绝经状态和体重指数。

目的：研究绝经因素和体重指数（BMI）对唾液生化成分的影响，并评估唾液代谢标志物对诊断乳腺癌的适用性：病例对照研究涉及 1438 人（乳腺癌，543 人；纤维腺瘤，597 人；对照组，298 人）。采用 36 项参数对唾液的生化成分进行了全面研究：结果：在比较乳腺癌、乳腺纤维腺瘤和对照组的唾液生化成分时，有必要考虑绝经状态，以及月经功能保留组患者的体重指数（小于 25 或大于 25）。研究发现，在乳腺癌发病期间，唾液中的一系列生化指标都会发生变化，与绝经和体重指数无关（总蛋白、尿素、尿酸、NO、α-氨基酸、谷氨酰转肽酶），在分析单个亚组时还必须考虑特定指标（咪唑化合物、LDH、过氧化氢酶、α-淀粉酶）。在对另一组叶状肿瘤（phyllodes）患者的研究中，我们发现某些生化指标的变化与乳腺癌相似，这些指标可归因于恶性肿瘤生长的代谢产物（蛋白质、α-氨基酸、钙、NO、丙酮酸、过氧化物酶、α-淀粉酶）：结论：我们发现唾液生化指标的广泛变化取决于纤维腺瘤和乳腺癌的存在。从临床实践的角度来看，这可能是监测纤维腺瘤患者病情的有用信息，因为仅靠仪器诊断很难对纤维腺瘤进行明确分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.