Development and Biomedical Application of Non-Noble Metal Nanomaterials in SERS.

IF 4.4 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Nanomaterials Pub Date : 2024-10-15 DOI:10.3390/nano14201654

Liping Chen, Hao Liu, Jiacheng Gao, Jiaxuan Wang, Zhihan Jin, Ming Lv, Shancheng Yan

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Abstract

Surface-enhanced Raman scattering (SERS) is vital in many fields because of its high sensitivity, fast response, and fingerprint effect. The surface-enhanced Raman mechanisms are generally electromagnetic enhancement (EM), which is mainly based on noble metals (Au, Ag, etc.), and chemical enhancement (CM). With more and more studies on CM mechanism in recent years, non-noble metal nanomaterial SERS substrates gradually became widely researched and applied due to their superior economy, stability, selectivity, and biocompatibility compared to noble metal. In addition, non-noble metal substrates also provide an ideal new platform for SERS technology to probe the mechanism of biomolecules. In this paper, we review the applications of non-noble metal nanomaterials in SERS detection for biomedical engineering in recent years. Firstly, we introduce the development of some more common non-noble metal SERS substrates and discuss their properties and enhancement mechanisms. Subsequently, we focus on the progress of the application of SERS detection of non-noble metal nanomaterials, such as analysis of biomarkers and the detection of some contaminants. Finally, we look forward to the future research process of non-noble metal substrate nanomaterials for biomedicine, which may draw more attention to the biosensor applications of non-noble metal nanomaterial-based SERS substrates.

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非贵金属纳米材料在 SERS 中的开发和生物医学应用。

表面增强拉曼散射（SERS）因其灵敏度高、响应速度快和指纹效应而在许多领域发挥着重要作用。表面增强拉曼机制一般有电磁增强（EM）和化学增强（CM）两种，前者主要基于贵金属（金、银等）。近年来，随着对 CM 机制的研究越来越多，非贵金属纳米材料 SERS 基底因其优于贵金属的经济性、稳定性、选择性和生物相容性，逐渐被广泛研究和应用。此外，非贵金属基底也为 SERS 技术探究生物大分子的机理提供了一个理想的新平台。本文回顾了近年来非贵金属纳米材料在生物医学工程 SERS 检测中的应用。首先，我们介绍了一些较为常见的非贵金属 SERS 基底的发展情况，并讨论了它们的特性和增强机制。随后，我们重点介绍了非贵金属纳米材料在 SERS 检测方面的应用进展，如生物标记物分析和一些污染物的检测。最后，我们展望了非贵金属基底纳米材料在生物医学领域的未来研究进程，希望能引起人们对基于非贵金属纳米材料的SERS基底的生物传感器应用的更多关注。

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来源期刊

Nanomaterials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.50

自引率

9.40%

发文量

3841

审稿时长

14.22 days

期刊介绍： Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.