Anticoagulant Effect of Snow mountain garlic: In Vitro Evaluation of Aqueous Extract.

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2024-10-20 DOI:10.3390/molecules29204958

Isabel Clark-Montoya, Yolanda Terán-Figueroa, Denisse de Loera, Darío Gaytán-Hernández, Jorge Alejandro Alegría-Torres, Rosa Del Carmen Milán-Segovia

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Abstract

Snow mountain garlic is traditionally eaten by Himalayan locals for its medicinal properties. Although different species of the genus Allium are known to have other biological effects, such as antiplatelet and antithrombotic activities, little is known about the anticoagulant effect of Snow mountain garlic, a member of the genus Allium. Therefore, the present study examined the in vitro anticoagulant effect of the aqueous extract, the lyophilized aqueous extract, and the isoflavone extract from the lyophilized aqueous extract of Snow mountain garlic in samples from 50 human blood donors. Compared to the control, concentrations of 25, 12.5, and 6.25 mg/100 µL lengthened the clotting times of prothrombin, and concentrations of 25 and 12.5 mg/100 µL lengthened the activated partial thromboplastin time (p ˂ 0.05). The isoflavone extract from the lyophilized aqueous extract containing isoflavones, organosulfur compounds, a polyphenol, and a steroid glycoside showed a significant effect (p ˂ 0.05) on the prothrombin time and the activated partial thromboplastin time at a dose of 20 µL (volume) compared to the control. The results regarding the use of Snow mountain garlic as a preventive measure and aid in treating thromboembolic disease are promising.

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雪山大蒜的抗凝血作用：水提取物的体外评估

喜马拉雅当地人历来食用雪山大蒜，因为它具有药用价值。虽然众所周知薤属的不同种类具有其他生物效应，如抗血小板和抗血栓活性，但对薤属植物雪山大蒜的抗凝血效应却知之甚少。因此，本研究检测了雪山大蒜的水提取物、冻干水提取物和冻干水提取物中的异黄酮提取物对 50 名人体献血者样本的体外抗凝作用。与对照组相比，25、12.5 和 6.25 毫克/100 微升的浓度可延长凝血酶原的凝结时间，25 和 12.5 毫克/100 微升的浓度可延长活化部分凝血活酶时间（p ˂0.05）。冻干水提取物中的异黄酮提取物含有异黄酮、有机硫化合物、一种多酚和一种甾体苷，与对照组相比，20 µL（体积）的剂量对凝血酶原时间和活化部分凝血活酶时间有显著影响（p ˂0.05）。将雪山大蒜用作预防和辅助治疗血栓栓塞性疾病的结果很有希望。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.