Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Obesity Science & Practice Pub Date : 2024-10-22 eCollection Date: 2024-10-01 DOI:10.1002/osp4.70019
Mehdi Hedayati, Majid Valizadeh, Behnaz Abiri
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Abstract

Background: Obesity is recognized as a risk factor for various cancers, including thyroid cancer. However, the association between different metabolic obesity phenotypes and thyroid cancer risk remains unclear. This systematic review aimed to comprehensively evaluate the existing literature to elucidate the association between metabolic obesity phenotypes and thyroid cancer risk.

Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were searched for relevant studies until April 2024. Studies examining the link between metabolic obesity phenotypes and thyroid cancer risk were included.

Results: Five cohort studies involving 831,510 participants met the inclusion criteria. Metabolically unhealthy obesity was consistently associated with an increased risk of thyroid cancer in both men and women. Central adiposity emerged as a significant predictor of thyroid cancer risk. Mechanistically, chronic inflammation, dysregulated adipokine secretion, hormonal imbalances, and altered signaling pathways may contribute to thyroid carcinogenesis. There is an ongoing debate regarding the risk associated with metabolically healthy obesity, with some suggesting potential protective effects due to favorable metabolic profiles.

Conclusion: This systematic review highlights the complex relationship between metabolic obesity phenotypes and thyroid cancer risk. The findings highlighted the importance of considering metabolic status alongside obesity in thyroid cancer risk assessment and intervention strategies.

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代谢性肥胖表型与甲状腺癌风险:对证据的系统探索。
背景:肥胖被认为是包括甲状腺癌在内的多种癌症的风险因素。然而,不同代谢性肥胖表型与甲状腺癌风险之间的关系仍不清楚。本系统综述旨在全面评估现有文献,以阐明代谢性肥胖表型与甲状腺癌风险之间的关联:本系统综述按照《系统综述和元分析首选报告项目》指南进行。检索了 PubMed、Scopus、EMBASE、Web of Science 和 Google Scholar 上截至 2024 年 4 月的相关研究。纳入了研究代谢性肥胖表型与甲状腺癌风险之间联系的研究:有五项队列研究符合纳入标准,涉及 831,510 名参与者。代谢性不健康肥胖与男性和女性罹患甲状腺癌的风险增加一直存在关联。中心性肥胖是甲状腺癌风险的重要预测因素。从机理上讲,慢性炎症、脂肪因子分泌失调、荷尔蒙失衡和信号通路改变可能会导致甲状腺癌的发生。关于代谢健康的肥胖所带来的风险,目前仍有争论,有些人认为由于代谢状况良好,肥胖具有潜在的保护作用:本系统综述强调了代谢性肥胖表型与甲状腺癌风险之间的复杂关系。研究结果强调了在甲状腺癌风险评估和干预策略中考虑代谢状况和肥胖的重要性。
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来源期刊
Obesity Science & Practice
Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-
CiteScore
4.20
自引率
4.50%
发文量
73
审稿时长
29 weeks
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