Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.

IF 5.4 2区 生物学 Q1 BIOLOGY Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-16 Epub Date: 2024-10-28 DOI:10.1098/rstb.2023.0482
Fernando A Campos, Eva C Wikberg, Joseph D Orkin, Yeonjoo Park, Noah Snyder-Mackler, Saul Cheves Hernandez, Ronald Lopez Navarro, Linda M Fedigan, Michael Gurven, James P Higham, Katharine M Jack, Amanda D Melin
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Abstract

Studying biological ageing in animal models can circumvent some of the confounds exhibited by studies of human ageing. Ageing research in non-human primates has provided invaluable insights into human lifespan and healthspan. Yet data on patterns of ageing from wild primates remain relatively scarce, centred around a few populations of catarrhine species. Here, we introduce the white-faced capuchin, a long-lived platyrrhine primate, as a promising new model system for ageing research. Like humans, capuchins are highly social, omnivorous generalists, whose healthspan and lifespan relative to body size exceed that of other non-human primate model species. We review recent insights from capuchin ageing biology and outline our expanding, integrative research programme that combines metrics of the social and physical environments with physical, physiological and molecular hallmarks of ageing across the natural life courses of multiple longitudinally tracked individuals. By increasing the taxonomic breadth of well-studied primate ageing models, we generate new insights, increase the comparative value of existing datasets to geroscience and work towards the collective goal of developing accurate, non-invasive and reliable biomarkers with high potential for standardization across field sites and species, enhancing the translatability of primate studies.This article is part of the discussion meeting issue 'Understanding age and society using natural populations'.

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将野生卷尾猴作为研究老龄化的社会和生态决定因素的模型系统。
在动物模型中研究生物老化可以避免人类老化研究中出现的一些问题。非人类灵长类动物的老化研究为人类的寿命和健康范围提供了宝贵的见解。然而,有关野生灵长类动物衰老模式的数据仍然相对稀少,主要集中在少数几个白额灵长类动物种群中。在这里,我们将白面卷尾猴--一种长寿的长尾灵长类动物--介绍给大家,作为老龄化研究的一个很有前途的新模型系统。与人类一样,卷尾猴也是高度社会化的杂食性动物,其健康寿命和相对于体型的寿命都超过了其他非人灵长类模型物种。我们回顾了卷尾猴衰老生物学的最新研究成果,并概述了我们不断扩展的综合研究计划,该计划将社会和自然环境指标与多个纵向追踪个体自然生命历程中的物理、生理和分子衰老标志相结合。通过增加分类学广度的研究良好的灵长类动物老化模型,我们产生了新的见解,提高了现有数据集对通用科学的比较价值,并努力实现开发准确、非侵入性和可靠的生物标志物的集体目标,这些生物标志物在不同野外地点和物种之间具有很高的标准化潜力,提高了灵长类动物研究的可转化性。
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来源期刊
CiteScore
11.80
自引率
1.60%
发文量
365
审稿时长
3 months
期刊介绍: The journal publishes topics across the life sciences. As long as the core subject lies within the biological sciences, some issues may also include content crossing into other areas such as the physical sciences, social sciences, biophysics, policy, economics etc. Issues generally sit within four broad areas (although many issues sit across these areas): Organismal, environmental and evolutionary biology Neuroscience and cognition Cellular, molecular and developmental biology Health and disease.
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