Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis.

IF 3.8 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Poultry Science Pub Date : 2024-10-19 DOI:10.1016/j.psj.2024.104412
Chala Adugna, Kai Wang, Jian Du, Chunmei Li
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引用次数: 0

Abstract

The effect of DON mycotoxins on broiler production performance and the small intestine is a critical factor in the health and well-being of broilers. Several studies have been conducted on this topic and have reported varying results and conclusions. Therefore, it is necessary to conduct systematic reviews and meta-analyses to thoroughly examine and draw unique conclusions. In this meta-analysis, we conducted a systematic review of multiple studies on the effects of DON mycotoxins in broilers. The analysis comprised 26 articles from reputable journals, and 14 parameters were identified based on the predetermined criteria. The forest plot results showed that DON treatment significantly reduced the ADFI and ADWG (SMD-1.50, 95 %CI [-1.68, -1.18]; I2= 51 %; p < 0.00001) and affected FCR (SMD 0.95, 95 %CI [ 0.62, 1.28]; I2= 77; p < 0.00001). In addition, it affects the small intestine structure duodenum (SMD -3.46, 95 %CI [-3.88, -3.05]; I2= 48 %; p < 0.00001), Jejunum (SMD -5.35, 95 %CI [-5.86, -4.83]; I2= 62 %; p < 0.00001), Ileum (SMD -2.6, 95 % CI [-3.12, -2.08]; I2= 82 %; p < 0.00001). Furthermore, DON exposure affects immunoglobulin (SMD -1.92, 95 % CI [ -2.39, -1.46]; I2 = 54 %; p < 0.00001) and antioxidant activities (SMD -2.1, 95 % CI [ -2.45, -1.75]; I2= 47 %; p < 0.00001). The overall effect of DON treatment was statistically significant compared with that of the control group. Furthermore, funnel plot analysis for publication bias did not reveal any significant asymmetry in most included studies. The results of this meta-analysis indicate that DON mycotoxins have a significant impact on both production performance and small intestine health and require strategic intervention.

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脱氧雪腐镰刀菌烯醇霉菌毒素对肉鸡生产性能和小肠健康的影响:综合荟萃分析
DON霉菌毒素对肉鸡生产性能和小肠的影响是影响肉鸡健康和福利的关键因素。关于这一主题已经进行了多项研究,报告的结果和结论各不相同。因此,有必要进行系统综述和荟萃分析,以彻底研究并得出独特的结论。在这项荟萃分析中,我们对有关 DON 霉菌毒素对肉鸡影响的多项研究进行了系统回顾。分析包括来自著名期刊的 26 篇文章,根据预定标准确定了 14 个参数。森林图结果显示,DON处理显著降低了ADFI和ADWG(SMD-1.50,95 %CI [ -1.68, -1.18]; I2= 51 %; p < 0.00001),并影响了FCR(SMD 0.95,95 %CI [ 0.62, 1.28]; I2= 77; p < 0.00001)。此外,它还影响小肠结构十二指肠(SMD -3.46,95 %CI [-3.88,-3.05];I2= 48 %;p < 0.00001)、空肠(SMD -5.35,95 %CI [-5.86,-4.83];I2= 62 %;p < 0.00001)、回肠(SMD -2.6,95 %CI [-3.12,-2.08];I2= 82 %;p < 0.00001)。此外,接触 DON 会影响免疫球蛋白(SMD -1.92,95 % CI [ -2.39,-1.46];I2= 54 %;p <0.00001)和抗氧化活性(SMD -2.1,95 % CI [ -2.45,-1.75];I2= 47 %;p <0.00001)。与对照组相比,DON 治疗的总体效果具有统计学意义。此外,针对发表偏倚的漏斗图分析并未发现大多数纳入研究存在明显的不对称性。这项荟萃分析的结果表明,DON霉菌毒素对生产性能和小肠健康都有重大影响,需要进行战略性干预。
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来源期刊
Poultry Science
Poultry Science 农林科学-奶制品与动物科学
CiteScore
7.60
自引率
15.90%
发文量
0
审稿时长
94 days
期刊介绍: First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.
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