Baseline and 2-year differences in spinal symptoms and spinal and hip mobility in early axial spondyloarthritis and non-axial spondyloarthritis chronic back pain patients.

IF 5.1 2区 医学 Q1 RHEUMATOLOGY RMD Open Pub Date : 2024-10-26 DOI:10.1136/rmdopen-2024-004713
Ana Bento da Silva, Sofia Ramiro, Miranda van Lunteren, Mary Lucy Marques, Marleen van de Sande, Camilla Fongen, Sofia Exarchou, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
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Abstract

Objective: To compare spinal symptoms and spinal/hip mobility at baseline and 2 years in early axial spondyloarthritis (axSpA) and non-axSpA chronic back pain (BP) patients.

Methods: Baseline and 2 years data of the SPondyloarthritis Caught Early cohort were analysed. Outcomes assessed: overall BP, BP at night, morning stiffness (MS) intensity, MS duration, occiput-to-wall distance (OWD), cervical rotation, chest expansion, lateral spinal flexion (LSF), modified Schober test (mSchober), intermalleolar distance (IMD) and Bath Ankylosing Spondylitis Metrology Index (BASMI). Linear or zero-inflated negative binomial regression was used to compare 2 years outcomes between groups (adjusting for baseline value, sex, age and use of non-steroidal anti-inflammatory drugs).

Results: There were 294 axSpA and 123 non-axSpA patients (mean symptom duration: 13 months). At baseline, non-axSpA patients had worse symptoms and mobility, except OWD (eg, mean(SD): BP at night 3.6 (2.9) axSpA vs 4.6 (2.7) non-axSpA; OWD 0.5 (1.2) vs 0.1 (0.7)). After 2 years, all symptoms and cervical rotation significantly improved in both groups, but LSF and mSchober only in axSpA. In multivariable analyses, axSpA was associated with larger improvements in BP at night (β (95% CI): -0.85 (-1.47; -0.23)), mSchober (0.26 (0.03; 0.50)), IMD (4.86 (1.93; 7.80)) and BASMI (-0.24 (-0.41; -0.08)), and with lower likelihood of a normal OWD (OR (95% CI): 0.09 (0.01; 0.83)).

Conclusion: Over 2 years, all spinal symptoms and some mobility measures improved in both groups, but impairments remained prevalent (particularly in non-axSpA). Nevertheless, axSpA was associated with larger improvements in BP at night, mSchober, IMD and BASMI, but with more OWD impairment.

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早期轴性脊柱关节炎和非轴性脊柱关节炎慢性背痛患者脊柱症状以及脊柱和髋关节活动度的基线和两年差异。
目的比较早期轴性脊柱关节炎(axSpA)和非轴性脊柱关节炎慢性背痛(BP)患者在基线和两年内的脊柱症状和脊柱/髋关节活动度:对脊柱关节炎早期发现队列的基线和两年数据进行分析。评估结果:总体血压、夜间血压、晨僵(MS)强度、晨僵持续时间、枕骨至墙壁距离(OWD)、颈椎旋转、胸廓扩张、脊柱侧屈(LSF)、改良舒伯试验(mSchober)、两椎间距离(IMD)和巴斯强直性脊柱炎计量指数(BASMI)。采用线性回归或零膨胀负二项回归比较各组两年的结果(调整基线值、性别、年龄和使用非甾体抗炎药的情况):共有 294 名轴索硬化症患者和 123 名非轴索硬化症患者(平均症状持续时间:13 个月)。基线时,非 axSpA 患者的症状和活动能力较差,但 OWD 除外(例如,平均值(标度):夜间血压 axSpA 患者为 3.6 (2.9) vs 非 axSpA 患者为 4.6 (2.7);OWD 为 0.5 (1.2) vs 0.1 (0.7))。2 年后,两组患者的所有症状和颈椎旋转均有明显改善,但只有 axSpA 患者的 LSF 和 mSchober 有明显改善。在多变量分析中,axSpA与夜间血压(β (95% CI):-0.85 (-1.47; -0.23))、mSchober (0.26 (0.03; 0.50))、IMD (4.86 (1.93; 7.80))和BASMI (-0.24 (-0.41; -0.08))的改善幅度较大以及OWD正常的可能性较低(OR (95% CI):0.09 (0.01; 0.83))相关:两年后,两组患者的所有脊柱症状和部分活动能力都有所改善,但损伤仍然普遍存在(尤其是在非 axSpA 患者中)。尽管如此,axSpA 患者夜间血压、mSchober、IMD 和 BASMI 的改善幅度更大,但 OWD 损伤程度更高。
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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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