A Framework for a New Paradigm of Opioid Drug Tapering Using Adjunct Drugs.

IF 5.1 Q1 SUBSTANCE ABUSE Substance Abuse and Rehabilitation Pub Date : 2024-10-19 eCollection Date: 2024-01-01 DOI:10.2147/SAR.S468259
Michael A Veronin, Justin P Reinert
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Abstract

The misuse of and dependency on prescription opioids represents a significant crisis at the national level, impacting not only the health of the public but also the societal and economic well-being. There is a critical need for strategies to reduce the dosage of prescribed opioids to limit opioid-associated adverse effects and lower the risk of addiction development in patients experiencing chronic pain. Opioid-sparing medications, when co-administered with opioids, enable a reduced opioid dose without loss of efficacy. This suggests the potential for using opioid adjunct drugs in opioid tapering, whereby opioid doses are lowered incrementally in a systematic manner to improve a patient's safety profile or quality of life. The objective of this report is two-fold: 1) to illustrate the potential for adjunct drugs in opioid tapering, and 2) to describe the steps needed to be taken to develop a framework for the use of adjunct drugs in opioid tapering. This can provide the impetus for further investigation into opioid tapering and the development of improved clinical care. The proposed project implements knowledge synthesis methods to develop the framework for a new paradigm of opioid drug tapering that incorporates opioid dosage reductions with adjunct drugs. Framework development is organized into three major phases: 1) Adjunct drug characterization, 2) Assessment of the opioid-sparing effect, and 3) Usability of data for clinicians. The knowledge gained from this project can provide a foundation for improved analgesia protocols for opioids and adjunctive drug therapy.

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使用辅助药物的阿片类药物减量新范例框架。
滥用和依赖处方阿片类药物是国家层面的重大危机,不仅影响公众健康,还影响社会和经济福祉。目前亟需制定减少处方阿片类药物剂量的策略,以限制阿片类药物相关的不良反应,降低慢性疼痛患者成瘾的风险。在与阿片类药物联合使用时,阿片类药物稀释药物可在不丧失疗效的情况下减少阿片类药物的剂量。这表明在阿片类药物减量治疗中使用阿片类辅助药物是有潜力的,即以系统的方式逐步降低阿片类药物的剂量,以改善患者的安全状况或生活质量。本报告的目的有二:1)说明辅助药物在阿片类药物减量治疗中的潜力;2)描述在阿片类药物减量治疗中制定辅助药物使用框架所需的步骤。这将为进一步研究阿片类药物减量和改进临床护理提供动力。拟议项目采用知识综合方法,为阿片类药物减量的新模式制定框架,将阿片类药物减量与辅助药物结合起来。框架开发分为三个主要阶段:1)辅助药物特征描述;2)阿片类药物稀释效果评估;3)数据对临床医生的可用性。从该项目中获得的知识可为改进阿片类药物和辅助药物治疗的镇痛方案奠定基础。
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来源期刊
自引率
0.00%
发文量
9
审稿时长
16 weeks
期刊最新文献
Patient Perceived Impact of Outpatient Group Substance Use Disorder Treatment in a Hybrid Model or Virtual-Only Model Relative to In-Person Delivery. Enhancing Outcomes in Opioid Use Disorder Treatment: An Economic Evaluation of Improving Medication Adherence for Buprenorphine Through Blister-Packaging. A Framework for a New Paradigm of Opioid Drug Tapering Using Adjunct Drugs. Incidence, Timing and Social Correlates of the Development of Opioid Use Disorder Among Clients Seeking Treatment for an Alcohol Use Problem: Changes Over the Three Waves of the Opioid Epidemic. Community-Based Medications First for Opioid Use Disorder - Care Utilization and Mortality Outcomes.
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