Botulinum Toxin Treatment of Psoriasis-A Comprehensive Review.

IF 3.9 3区 医学 Q2 FOOD SCIENCE & TECHNOLOGY Toxins Pub Date : 2024-10-18 DOI:10.3390/toxins16100449
Ali Ghaseminejad-Bandpey, Shahroo Etemadmoghadam, Bahman Jabbari
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Abstract

A literature search on the subject of botulinum toxin treatment in psoriasis found 15 relevant articles, 11 on human subjects and 4 on animal studies. Of the human data, eight were clinical trials and three were single case reports. Seven out of eight clinical trials, all open-label, reported improvement in psoriasis following intradermal or subcutaneous botulinum toxin injections. One double-blind, placebo-controlled study, which used a smaller dose than the open-label studies, did not note a healing effect. Animal studies have shown that injection of botulinum toxins in the skin heals psoriatic skin lesions and can reduce the level of interleukins (ILs) and cytokines as well as inflammatory cells in psoriatic plaques. There is a need for controlled, blinded studies conducted in larger numbers of patients with doses that have shown promise in open-label studies.

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肉毒杆菌毒素治疗牛皮癣--全面回顾。
通过对有关肉毒杆菌毒素治疗银屑病的文献进行检索,发现了 15 篇相关文章,其中 11 篇涉及人体研究,4 篇涉及动物研究。在人体数据中,8 篇为临床试验,3 篇为单个病例报告。八项临床试验中有七项报告了皮内或皮下注射肉毒毒素后银屑病的改善情况,这些试验均为开放标签试验。一项双盲、安慰剂对照研究使用的剂量比开放标签研究的剂量小,但没有发现治疗效果。动物实验表明,在皮肤中注射肉毒杆菌毒素可以治愈银屑病皮损,并能降低白细胞介素(ILs)和细胞因子的水平以及银屑病斑块中的炎症细胞。目前还需要对更多患者进行盲法对照研究,并使用在开放标签研究中显示有希望的剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Toxins
Toxins TOXICOLOGY-
CiteScore
7.50
自引率
16.70%
发文量
765
审稿时长
16.24 days
期刊介绍: Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
期刊最新文献
Characterization of Kunitz-Domain Anticoagulation Peptides Derived from Acinetobacter baumannii Exotoxin Protein F6W77. Description of Pegethrix niliensis sp. nov., a Novel Cyanobacterium from the Nile River Basin, Egypt: A Polyphasic Analysis and Comparative Study of Related Genera in the Oculatellales Order. Botulinum Toxin Treatment of Psoriasis-A Comprehensive Review. Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology. Scoliidines: Neuroprotective Peptides in Solitary Scoliid Wasp Venoms.
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