Determination of Bisphenol Compounds and the Bioaccumulation after Co-Exposure with Polyethylene Microplastics in Zebrafish.

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2024-09-27 DOI:10.3390/toxics12100702

Moyong Xue, Ming Jia, Yuchang Qin, Jing Li, Ting Yao, Frédéric Francis, Xu Gu

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Abstract

Knowledge regarding the combined toxicity mechanism of bisphenol compounds and microplastics (MPs) on organisms remains limited. In this study, we first developed an accurate and sensitive method to simultaneously quantify two bisphenol compounds and evaluate their accumulation and tissue distribution after co-exposure with MPs in zebrafish. Then, we determined the bioaccumulation potential of bisphenol A (BPA) and bisphenol S (BPS) in adult zebrafish in the absence and presence of MPs. Bisphenol compounds were found to accumulate in different tissues of zebrafish, with BPS showing lower accumulation levels compared to BPA. Importantly, we discovered that the presence of MPs could exacerbate the accumulation of bisphenol compounds in biological tissues. These findings highlight the enhanced bioavailability and risk posed by the co-exposure of bisphenol compounds and MPs, underscoring the need for further investigation into their combined environmental and biological health impacts.

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测定斑马鱼体内的双酚化合物以及与聚乙烯微塑料共同暴露后的生物累积。

有关双酚化合物和微塑料（MPs）对生物的综合毒性机制的知识仍然有限。在本研究中，我们首先开发了一种精确而灵敏的方法，用于同时量化两种双酚化合物，并评估它们在斑马鱼体内与微塑料共同暴露后的积累和组织分布情况。然后，我们测定了双酚 A（BPA）和双酚 S（BPS）在没有 MPs 和有 MPs 的情况下在成年斑马鱼体内的生物累积潜力。研究发现，双酚化合物会在斑马鱼的不同组织中蓄积，与双酚 A 相比，双酚 S 的蓄积水平较低。重要的是，我们发现 MPs 的存在会加剧双酚化合物在生物组织中的积累。这些发现凸显了双酚化合物和 MPs 共同暴露所带来的更高生物利用率和风险，强调了进一步研究它们对环境和生物健康的综合影响的必要性。

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.