The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder.

IF 5.8 1区 医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-10-24 DOI:10.1038/s41398-024-03169-3
Hui Chen, Peiqu Liu, Xianliang Chen, Jiali Liu, Huajia Tang, Yusheng Tian, Xiaoping Wang, Fengmei Lu, Jiansong Zhou
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Abstract

Previous studies have revealed morphologic alterations in patients with major depressive disorder (MDD) with experiences of childhood trauma. However, the underlying neural mechanisms remain largely unknown. This study aims to explore the brain structural changes and their possible mediation role in the relationship between childhood maltreatment and psychological resilience in drug-naïve adolescents with first-episode MDD. A total of 57 adolescents with first-episode MDD and 36 healthy controls (HCs) completed the T1-weighted magnetic resonance imaging scan. The adverse childhood experiences and current psychological resilience were assessed using the Childhood Trauma Questionnaire-Short Form and the Connor Davidson Resilience Scale, respectively. The voxel-based morphometry approach was applied to examine changes in the gray matter volume (GMV). Compared with the HCs, adolescents with MDD had significantly reduced GMV volumes in the left fusiform gyrus, right orbitofrontal gyrus, right superior temporal gyrus, right calcarine cortex, right middle frontal gyrus, left angular gyrus, right precuneus, right posterior cingulate gyrus, and right posterior central gyrus, as well as significantly increased GMV volumes in the left lenticular putamen and right lenticular pallidum. The GMV of the right calcarine cortex was found to be negatively correlated with the severity of emotional abuse and positively correlated with the level of psychological resilience. Moreover, the GMV of the right calcarine cortex might partially mediate the relationship between childhood maltreatment and psychological resilience. The present study provided further evidence for structural impairments in adolescents with MDD. Our findings also confirmed the important role of depression-related GMV changes in childhood growth experiences and psychological resilience characteristics during adolescent brain maturation.

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灰质体积在初发重度抑郁障碍青少年的童年虐待与心理复原力之间的中介作用。
以往的研究显示,有童年创伤经历的重度抑郁症(MDD)患者会出现形态学改变。然而,其背后的神经机制在很大程度上仍不为人知。本研究旨在探讨初次发病的MDD患者的大脑结构变化及其在童年虐待与心理复原力之间可能的中介作用。共有57名初发MDD青少年和36名健康对照组(HCs)完成了T1加权磁共振成像扫描。童年不良经历和目前的心理复原力分别通过童年创伤问卷简表和康纳-戴维森复原力量表进行评估。研究人员采用基于体素的形态计量学方法来检测灰质体积(GMV)的变化。与正常人相比,患有 MDD 的青少年左侧纺锤形回、右侧眶额回、右侧颞上回、右侧钙皮质、右侧额中回、左侧角回、右侧楔前回、右侧扣带回后部和右侧中央后回的灰质体积明显减少,而左侧皮质透镜和右侧苍白球透镜的灰质体积则明显增加。研究发现,右侧钙皮质的 GMV 与情感虐待的严重程度呈负相关,而与心理复原力水平呈正相关。此外,右心盏皮层的GMV可能部分介导了童年虐待与心理复原力之间的关系。本研究进一步证明了患有 MDD 的青少年存在结构性损伤。我们的研究结果还证实,在青少年大脑成熟过程中,与抑郁症相关的GMV变化在童年成长经历和心理复原力特征中起着重要作用。
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来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
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