Photoactivated chromophore for keratitis-Corneal cross-linking in dogs and cats: A retrospective study in Italy.

IF 1.7 4区 农林科学 Q2 VETERINARY SCIENCES Veterinary ophthalmology Pub Date : 2024-10-25 DOI:10.1111/vop.13284
Manuela Crasta, Eva Gimenez, Pier Carlo Ostan, Kevin Arteaga
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Abstract

Objective: To evaluate the success and failure rate of photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) therapy in a single population of dogs and cats. To identify the usefulness of the PACK-CXL based on ulcer depth and establish a cutoff at which this procedure could be recommended. To analyze the influence of the different variables in corneal healing time and to report the presence of secondary endothelial damage and cataract formation.

Materials and methods: Medical records of dogs and cats with presumptive infectious keratitis which underwent accelerated epithelium-off PACK-CXL between 2016 and 2023 were reviewed and analyzed.

Results: Records for 369 animals were included, and the overall success rate for healing was 97% (range 4-74 days and no rescue procedure). The second success (re-epithelialization <30 days and no rescue procedure) rate was 86%, and a total of 40 eyes needed more than 1 month for the corneal repair. Corneal ulcers were classified in three categories based on the depth: 0%-33% (46%), 34%-66% (37.4%), and 67%-100% (16.5%). The cutoff at which PACK-CXL had a higher probability of failure was with ulcer depth >66.5%. Animals who suffered from keratomalacia and hypopyon at presentation, or were treated with topical serum or gentamicin after PACK-CXL showed an increase in epithelial healing time (EHT). Increasing age, brachycephalic conformation, keratomalacia alone, and deeper ulcers were identified as risk factors for the treatment outcome. Secondary endothelial injury or cataract formation was not noted in this study.

Conclusions: Accelerated PACK-CXL is a non-invasive, adjunctive treatment to medical therapy, which can be used in presumed infectious keratitis with a high probability of success. However, it is important to take in consideration the patient age, skull conformation, presence of keratomalacia, and the ulcer depth.

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用于猫狗角膜炎-角膜交联的光活性发色团:意大利的一项回顾性研究。
目的评估光激活发色团角膜炎-角膜交联(PACK-CXL)疗法在单一猫狗群体中的成功率和失败率。根据溃疡深度确定 PACK-CXL 的有用性,并确定推荐使用该疗法的临界值。分析不同变量对角膜愈合时间的影响,并报告是否存在继发性内皮损伤和白内障形成:回顾并分析2016年至2023年期间接受加速上皮脱落PACK-CXL的推定感染性角膜炎犬猫的医疗记录:结果:共纳入 369 只动物的记录,总体治愈成功率为 97%(范围为 4-74 天,无抢救程序)。第二次成功率为 66.5%。发病时患有角膜瘤和角膜缺损的动物,或在 PACK-CXL 治疗后使用局部血清或庆大霉素治疗的动物,其上皮愈合时间(EHT)都有所延长。年龄增大、畸形、单纯角膜病变和溃疡较深被认为是影响治疗结果的风险因素。本研究未发现继发性内皮损伤或白内障形成:结论:PACK-CXL 加速疗法是一种非侵入性的辅助治疗方法,可用于推测的感染性角膜炎,成功几率很高。然而,重要的是要考虑患者的年龄、颅骨结构、是否存在角膜病变以及溃疡深度。
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来源期刊
Veterinary ophthalmology
Veterinary ophthalmology 农林科学-兽医学
CiteScore
2.70
自引率
37.50%
发文量
82
审稿时长
12-24 weeks
期刊介绍: Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of: Clinical and investigational veterinary and comparative ophthalmology; Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species; Experimental models of both animal and human ocular disease in veterinary species; Anatomic studies of the animal eye; Physiological studies of the animal eye; Pharmacological studies of the animal eye.
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