[Interpretation of the key points of Regulation for Diagnosis and Treatment of Non-neonatal Tetanus (2024 Edition)].

Q1 Medicine 中华流行病学杂志 Pub Date : 2024-10-25 DOI:10.3760/cma.j.cn112338-20241017-00640

S Liu, C Liu, J Y Liu, Q J Chen, X Kang, P Lan, Q S Xue, Z G Zhu, X J Lyu, W W Yin, C L Wang

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Abstract

Non-neonatal tetanus is an acute, specific, toxic disease in patients over 28 days of age, characterized by continuous rigidity and paroxysmal spasms of the skeletal muscles throughout the body caused by the intrusion of Clostridium tetani through skin or mucosal membrane into the body and reproducing in anaerobic environments to produce exotoxins. The mortality rate of severe patients is close to 100% without medical intervention. Even with aggressive comprehensive treatment, the global mortality rate remains at 30%-50%, making it a potentially fatal disease. In order to standardize the diagnosis, treatment and prevention of non-neonatal tetanus, based on "Regulation for Diagnosis and Treatment of Non-Neonatal Tetanus (2019)", experts have revised this regulation according to clinical practice and recent research progress in this field to guide medical institutions in the prevention and control of non-neonatal tetanus. This article interprets the key points and basis for updating the 2024 edition regulation to guide clinical implementation and application.

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[非新生儿破伤风诊治规范（2024 年版）要点解读]。

非新生儿破伤风是一种急性、特异性、中毒性疾病，好发于 28 天以上的患者，其特征是全身骨骼肌持续僵硬和阵发性痉挛，这是由于破伤风梭菌通过皮肤或粘膜侵入体内，并在厌氧环境中繁殖产生外毒素所致。在没有医疗干预的情况下，重症患者的死亡率接近 100%。即使进行了积极的综合治疗，全球死亡率仍高达 30%-50%，是一种潜在的致命疾病。为规范非新生儿破伤风的诊断、治疗和预防，在《非新生儿破伤风诊疗规范（2019年版）》的基础上，专家根据临床实践和该领域最新研究进展，对该规范进行了修订，以指导医疗机构做好非新生儿破伤风的防控工作。本文解读2024年版规程的更新要点和依据，以指导临床实施和应用。

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来源期刊

中华流行病学杂志 Medicine-Medicine (all)

CiteScore

5.60

自引率

0.00%

发文量

8981

期刊介绍： Chinese Journal of Epidemiology, established in 1981, is an advanced academic periodical in epidemiology and related disciplines in China, which, according to the principle of integrating theory with practice, mainly reports the major progress in epidemiological research. The columns of the journal include commentary, expert forum, original article, field investigation, disease surveillance, laboratory research, clinical epidemiology, basic theory or method and review, etc. The journal is included by more than ten major biomedical databases and index systems worldwide, such as been indexed in Scopus, PubMed/MEDLINE, PubMed Central (PMC), Europe PubMed Central, Embase, Chemical Abstract, Chinese Science and Technology Paper and Citation Database (CSTPCD), Chinese core journal essentials overview, Chinese Science Citation Database (CSCD) core database, Chinese Biological Medical Disc (CBMdisc), and Chinese Medical Citation Index (CMCI), etc. It is one of the core academic journals and carefully selected core journals in preventive and basic medicine in China.