Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample.

Q3 Medicine Open Respiratory Medicine Journal Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI:10.2174/0118743064322829240801094830
Mohamad El Labban, Roba El-Zibaoui, Syed Muhammad Usama, Fayreal Niaz, Abbe Cohen, Peter Krastev, Syed Khan, Salim Surani
{"title":"Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample.","authors":"Mohamad El Labban, Roba El-Zibaoui, Syed Muhammad Usama, Fayreal Niaz, Abbe Cohen, Peter Krastev, Syed Khan, Salim Surani","doi":"10.2174/0118743064322829240801094830","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The obesity paradox suggests that obese patients with Chronic Obstructive Pulmonary Disease Exacerbation (COPDE) may have better outcomes. COPD patients are at a higher risk of becoming malnourished, which has been linked to poor outcomes.</p><p><strong>Objective: </strong>This paper aims to study the impact of malnutrition in patients with and without obesity hospitalized with COPDE.</p><p><strong>Methods: </strong>Our retrospective study analyzed data from the National Inpatient Sample dataset between 2017 and 2020 to observe patients who were hospitalized with COPDE. The patients were divided into two groups: with and without malnutrition. The outcomes included all-cause mortality, invasive mechanical ventilation, length of stay, and total charge. We adjusted for confounders using multivariate regression model analysis.</p><p><strong>Results: </strong>The study involved 392,920 patients with COPDE, out of which 5720 (1.45%) were diagnosed with malnutrition. Most of the patients in both groups were female, white, and under Medicare coverage. The mean age was higher in patients with malnutrition (67.6 <i>vs</i>. 64 years). In both groups, the rates of admissions were lowest in 2020 compared to three years prior. The rates and adjusted odds ratios of all-cause mortality were higher in patients with malnutrition (3.59% <i>vs</i>. 0.61%, P <0.01; adjusted odds ratio (aOR) 2.36, P<0.01, CI 1.8-3.7). We observed comparable findings when using invasive mechanical ventilation (13.2% <i>vs</i>. 2.82%, P<0.01, aOR 4.9, P<0.01, 3.9-6). Malnourished patients had a lengthier hospital stay and a greater total charge.</p><p><strong>Conclusion: </strong>Malnutrition was identified as an independent risk factor associated with worse outcomes in obese patients admitted with COPD exacerbation.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"18 ","pages":"e18743064322829"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11499682/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Respiratory Medicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118743064322829240801094830","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The obesity paradox suggests that obese patients with Chronic Obstructive Pulmonary Disease Exacerbation (COPDE) may have better outcomes. COPD patients are at a higher risk of becoming malnourished, which has been linked to poor outcomes.

Objective: This paper aims to study the impact of malnutrition in patients with and without obesity hospitalized with COPDE.

Methods: Our retrospective study analyzed data from the National Inpatient Sample dataset between 2017 and 2020 to observe patients who were hospitalized with COPDE. The patients were divided into two groups: with and without malnutrition. The outcomes included all-cause mortality, invasive mechanical ventilation, length of stay, and total charge. We adjusted for confounders using multivariate regression model analysis.

Results: The study involved 392,920 patients with COPDE, out of which 5720 (1.45%) were diagnosed with malnutrition. Most of the patients in both groups were female, white, and under Medicare coverage. The mean age was higher in patients with malnutrition (67.6 vs. 64 years). In both groups, the rates of admissions were lowest in 2020 compared to three years prior. The rates and adjusted odds ratios of all-cause mortality were higher in patients with malnutrition (3.59% vs. 0.61%, P <0.01; adjusted odds ratio (aOR) 2.36, P<0.01, CI 1.8-3.7). We observed comparable findings when using invasive mechanical ventilation (13.2% vs. 2.82%, P<0.01, aOR 4.9, P<0.01, 3.9-6). Malnourished patients had a lengthier hospital stay and a greater total charge.

Conclusion: Malnutrition was identified as an independent risk factor associated with worse outcomes in obese patients admitted with COPD exacerbation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
慢性阻塞性肺疾病恶化患者的营养不良和肥胖,来自全国住院患者样本的启示。
背景:肥胖悖论表明,慢性阻塞性肺疾病加重期(COPDE)的肥胖患者可能获得更好的治疗效果。慢性阻塞性肺病患者营养不良的风险较高,而营养不良与不良预后有关:本文旨在研究营养不良对 COPDE 住院患者和非肥胖患者的影响:我们的回顾性研究分析了 2017 年至 2020 年间全国住院患者样本数据集的数据,观察 COPDE 住院患者的情况。患者被分为两组:有营养不良和无营养不良。研究结果包括全因死亡率、侵入性机械通气、住院时间和总费用。我们通过多变量回归模型分析对混杂因素进行了调整:研究涉及 392 920 名 COPDE 患者,其中 5720 人(1.45%)被诊断为营养不良。两组患者中大多数为女性、白人和医保患者。营养不良患者的平均年龄更高(67.6 岁对 64 岁)。与三年前相比,2020 年两组患者的入院率都最低。营养不良患者的全因死亡率和调整后的几率比更高(3.59% vs. 0.61%,P vs. 2.82%,PC结论:营养不良是导致慢性阻塞性肺疾病加重的肥胖患者预后较差的一个独立风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Open Respiratory Medicine Journal
Open Respiratory Medicine Journal Medicine-Pulmonary and Respiratory Medicine
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: The Open Respiratory Medicine Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in respiratory medicine. Topics covered include: -COPD- Occupational disorders, and the role of allergens and pollutants- Asthma- Allergy- Non-invasive ventilation- Therapeutic intervention- Lung cancer- Lung infections respiratory diseases- Therapeutic interventions- Adult and paediatric medicine- Cell biology. The Open Respiratory Medicine Journal, a peer reviewed journal, is an important and reliable source of current information on important recent developments in the field. The emphasis will be on publishing quality articles rapidly and making them freely available worldwide.
期刊最新文献
Recommendations on Rapid Diagnostic Point-of-care Molecular Tests for Respiratory Infections in the United Arab Emirates. The use of Heated, Humidified, High-flow Nasal Cannulas, and Length of Hospital Stay Among Extremely Preterm Infants. The Protective Role of the Ratio of Arterial Partial Pressure of Oxygen and Fraction of Inspired Oxygen after Re-Supination in the Survival of Patients with Severe COVID-19 Pneumonia. PDE4 Inhibitors and their Potential Combinations for the Treatment of Chronic Obstructive Pulmonary Disease: A Narrative Review. Malnutrition and Obesity in Patients with COPD Exacerbation, Insights from the National Inpatient Sample.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1