Vitamin D Supplementation for Children with Epilepsy on Antiseizure Medications: A Randomized Controlled Trial.

IF 2 4区 医学 Q2 PEDIATRICS Children-Basel Pub Date : 2024-09-28 DOI:10.3390/children11101187
Fahad A Bashiri, Abrar Hudairi, Muddathir H Hamad, Lujain K Al-Sulimani, Doua Al Homyani, Dimah Al Saqabi, Amal Y Kentab, Reem A Al Khalifah
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Abstract

Background: Antiseizure medications (ASMs) are crucial for managing epilepsy in children. However, a well-documented side effect of ASMs is their impact on bone health, often due to interference with vitamin D metabolism. This can lead to vitamin D deficiency in children with epilepsy. This study aimed to determine if a daily dose of 400 IU or 1000 IU would maintain adequate vitamin D levels in children with epilepsy.

Methods: A phase IV randomized controlled trial enrolled children aged 2-16 years with epilepsy and receiving antiseizure medications. Children were divided into two groups: the monotherapy group, which was defined as children on one antiseizure medication (ASM), and the polytherapy group, which was defined as children receiving two or more ASMs. Eligible children with levels above 75 nmol/L were randomized to receive a maintenance dose of either 400 IU/day or 1000 IU/day of cholecalciferol. Baseline and 6-month assessments included demographic data, anthropometric measurements, seizure type, medications, seizure control, and 25(OH)D level.

Results: Out of 163 children, 90 were on monotherapy and 25 on polytherapy. After 6 months of vitamin D maintenance, the proportion of children with 25(OH)D concentration below 75 nmol/L was 75.0% in the 400 IU group and 54.8% in the 1000 IU group. In the monotherapy group, baseline seizure-free children increased from 69% to 83.6% after treating vitamin D deficiency.

Conclusion: Daily vitamin D supplementation with 1000 IU may be beneficial for children with epilepsy, particularly those receiving monotherapy, to maintain sufficiency and potentially improve seizure control.

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为服用抗癫痫药物的癫痫患儿补充维生素 D:随机对照试验
背景:抗癫痫药物(ASMs)是控制儿童癫痫的关键。然而,ASMs 的副作用已得到充分证实,那就是对骨骼健康的影响,这通常是由于维生素 D 代谢受到干扰所致。这可能导致癫痫患儿维生素 D 缺乏。本研究旨在确定每日剂量为 400 IU 或 1000 IU 能否维持癫痫患儿体内充足的维生素 D 水平:一项 IV 期随机对照试验招募了 2-16 岁患有癫痫并正在接受抗癫痫药物治疗的儿童。患儿被分为两组:单药治疗组和多药治疗组,单药治疗组指服用一种抗癫痫药物(ASM)的患儿,多药治疗组指服用两种或两种以上抗癫痫药物的患儿。符合条件且胆钙化醇水平高于 75 nmol/L 的儿童被随机分配到胆钙化醇维持剂量为 400 IU/天或 1000 IU/天的治疗组。基线和6个月评估包括人口统计学数据、人体测量、癫痫发作类型、药物、癫痫发作控制情况和25(OH)D水平:结果:在163名儿童中,90名儿童接受了单药治疗,25名儿童接受了多药治疗。维持维生素 D 6 个月后,25(OH)D 浓度低于 75 nmol/L 的儿童比例在 400 IU 组为 75.0%,在 1000 IU 组为 54.8%。在单一疗法组中,治疗维生素 D 缺乏症后,无癫痫发作儿童的基线比例从 69% 提高到 83.6%:结论:每日补充 1000 IU 维生素 D 可能对癫痫患儿,尤其是接受单一疗法的患儿有益,可维持充足的维生素 D,并有可能改善癫痫发作控制。
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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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