Tear-Based Ocular Wearable Biosensors for Human Health Monitoring.

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL Biosensors-Basel Pub Date : 2024-10-08 DOI:10.3390/bios14100483
Arunima Rajan, Jithin Vishnu, Balakrishnan Shankar
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Abstract

Wearable tear-based biosensors have garnered substantial interest for real time monitoring with an emphasis on personalized health care. These biosensors utilize major tear biomarkers such as proteins, lipids, metabolites, and electrolytes for the detection and recording of stable biological signals in a non-invasive manner. The present comprehensive review delves deep into the tear composition along with potential biomarkers that can identify, monitor, and predict certain ocular diseases such as dry eye disease, conjunctivitis, eye-related infections, as well as diabetes mellitus. Recent technologies in tear-based wearable point-of-care medical devices, specifically the state-of-the-art and prospects of glucose, pH, lactate, protein, lipid, and electrolyte sensing from tear are discussed. Finally, the review addresses the existing challenges associated with the widespread application of tear-based sensors, which will pave the way for advanced scientific research and development of such non-invasive health monitoring devices.

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基于泪液的眼部可穿戴生物传感器用于人体健康监测。
基于泪液的可穿戴生物传感器在实时监测方面引起了人们的极大兴趣,其重点在于个性化医疗保健。这些生物传感器利用主要的泪液生物标记物,如蛋白质、脂类、代谢物和电解质,以非侵入方式检测和记录稳定的生物信号。本综述深入探讨了泪液成分以及潜在的生物标记物,这些标记物可以识别、监测和预测某些眼部疾病,如干眼症、结膜炎、眼部相关感染以及糖尿病。报告还讨论了基于泪液的可穿戴护理点医疗设备的最新技术,特别是泪液中葡萄糖、pH 值、乳酸盐、蛋白质、脂质和电解质传感的最新技术和前景。最后,该综述探讨了与广泛应用泪液传感器相关的现有挑战,这将为此类无创健康监测设备的高级科学研究和开发铺平道路。
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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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