Follicular T cells and the control of IgE responses.

IF 6.2 2区 医学 Q1 ALLERGY Allergology International Pub Date : 2024-10-24 DOI:10.1016/j.alit.2024.09.007
Pablo F Cañete, Di Yu
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Abstract

Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. In this review, we will examine the molecular mechanisms governing the IgE response, with a particular emphasis on the key cytokines and signaling pathways. We will discuss the exclusion of IgE-producing B cells from germinal centers and explore the recently established role of follicular T cell function and heterogeneity in driving or curtailing these immune responses. Additionally, we will assess the current state of major monoclonal antibodies and allergen immunotherapies designed to counteract Th2-driven inflammation, as well as reflect on the need to investigate how these biologics impact Tfh cell activity, differentiation, and function, as these insights could pave the way for much-needed therapeutic innovation in the treatment of allergic diseases.

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滤泡 T 细胞与 IgE 反应的控制。
过敏症被认为是 21 世纪的流行病,尽管数十年的研究已经证实 Th2 细胞与 IgE 介导的致病性过敏性疾病之间存在直接联系,但直到最近几年,T 滤泡辅助细胞(Tfh)才成为这些反应的关键驱动因素。在这篇综述中,我们将研究支配 IgE 反应的分子机制,特别强调关键细胞因子和信号通路。我们将讨论生殖中心对产生 IgE 的 B 细胞的排斥,并探讨最近确立的滤泡 T 细胞功能和异质性在驱动或抑制这些免疫反应中的作用。此外,我们还将评估旨在对抗 Th2 驱动的炎症的主要单克隆抗体和过敏原免疫疗法的现状,并思考研究这些生物制剂如何影响 Tfh 细胞的活性、分化和功能的必要性,因为这些见解可以为治疗过敏性疾病所急需的创新疗法铺平道路。
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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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