Constructing a predictive model based on peripheral blood signs to differentiate infectious mononucleosis from chronic active EBV infection.

IF 1.4 4区 医学 Q4 INFECTIOUS DISEASES Journal of Infection in Developing Countries Pub Date : 2024-09-30 DOI:10.3855/jidc.19233
Jin Hua Yuan, Chong Jie Pang, Shuang Long Yuan
{"title":"Constructing a predictive model based on peripheral blood signs to differentiate infectious mononucleosis from chronic active EBV infection.","authors":"Jin Hua Yuan, Chong Jie Pang, Shuang Long Yuan","doi":"10.3855/jidc.19233","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To develop a prediction model based on peripheral blood signs to distinguish between infectious mononucleosis and chronic active EBV infection.</p><p><strong>Methods: </strong>Retrospective data was collected for 60 patients with IM (IM group) and 20 patients with CAEBV infection (CAEBV group) who were hospitalized and diagnosed at the General Hospital of Tianjin Medical University between December 2018 and September 2022. The analyses used were univariate and LASSO (least absolute shrinkage and selection operator) logistic regression.</p><p><strong>Results: </strong>Univariate analyses revealed that both IM and CAEBV-infected patients displayed overlapping and intersecting clinical manifestations, such as fever, sore throat, enlarged lymph nodes, and enlargement of the liver and spleen, and that in contrast to inflammatory responses in peripheral blood, CAEBV-infected patients had more severe inflammatory responses. Nine biomarkers-HGB, lymphocyte count, percentage of lymphocytes, ALB, fibrinogen, CRP, IFN-, IL-6, and EBV-DNA load-were subsequently selected by LASSO logistic regression modeling to serve as discriminatory models.</p><p><strong>Conclusions: </strong>Our investigation offers a solid foundation for diagnosing IM and CAEBV infection using the LASSO logistic regression model based on the significance and availability of peripheral blood indicators. Infected patients with CAEBV require early medical attention.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection in Developing Countries","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3855/jidc.19233","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To develop a prediction model based on peripheral blood signs to distinguish between infectious mononucleosis and chronic active EBV infection.

Methods: Retrospective data was collected for 60 patients with IM (IM group) and 20 patients with CAEBV infection (CAEBV group) who were hospitalized and diagnosed at the General Hospital of Tianjin Medical University between December 2018 and September 2022. The analyses used were univariate and LASSO (least absolute shrinkage and selection operator) logistic regression.

Results: Univariate analyses revealed that both IM and CAEBV-infected patients displayed overlapping and intersecting clinical manifestations, such as fever, sore throat, enlarged lymph nodes, and enlargement of the liver and spleen, and that in contrast to inflammatory responses in peripheral blood, CAEBV-infected patients had more severe inflammatory responses. Nine biomarkers-HGB, lymphocyte count, percentage of lymphocytes, ALB, fibrinogen, CRP, IFN-, IL-6, and EBV-DNA load-were subsequently selected by LASSO logistic regression modeling to serve as discriminatory models.

Conclusions: Our investigation offers a solid foundation for diagnosing IM and CAEBV infection using the LASSO logistic regression model based on the significance and availability of peripheral blood indicators. Infected patients with CAEBV require early medical attention.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
构建基于外周血体征的预测模型,以区分传染性单核细胞增多症和慢性活动性 EBV 感染。
目的建立一个基于外周血体征的预测模型,以区分传染性单核细胞增多症和慢性活动性EB病毒感染:收集2018年12月至2022年9月期间在天津医科大学总医院住院确诊的60例IM患者(IM组)和20例CAEBV感染患者(CAEBV组)的回顾性数据。采用的分析方法为单变量和LASSO(最小绝对收缩和选择算子)逻辑回归:单变量分析显示,IM和CAEBV感染患者的临床表现有重叠和交叉,如发热、咽痛、淋巴结肿大、肝脾肿大等,与外周血炎症反应相比,CAEBV感染患者的炎症反应更为严重。随后,通过 LASSO 逻辑回归模型筛选出九种生物标志物--HGB、淋巴细胞计数、淋巴细胞百分比、ALB、纤维蛋白原、CRP、IFN-、IL-6 和 EBV-DNA 负载,作为判别模型:我们的研究为根据外周血指标的重要性和可用性使用 LASSO 逻辑回归模型诊断 IM 和 CAEBV 感染奠定了坚实的基础。感染 CAEBV 的患者需要尽早就医。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.70
自引率
5.30%
发文量
239
审稿时长
4-8 weeks
期刊介绍: The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.
期刊最新文献
Clinical characteristics, depression, anxiety, and stress of medical workers during the COVID-19 pandemic: a cross-sectional survey. Clinical profile of patients with surgical brain abscesses and etiology in a reference hospital. Constructing a predictive model based on peripheral blood signs to differentiate infectious mononucleosis from chronic active EBV infection. Correlation of the severity of the clinical presentation of SARS-CoV-2 pneumonia with respiratory function parameters in the post-COVID period. Distribution of vectors and arboviruses, and healthcare workers' knowledge of vector-borne diseases in Armenia.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1