Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-26 DOI:10.1016/j.numecd.2024.09.023

Procolo Di Bonito, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia Del Giudice, Maria Rosaria Licenziati, Nicola Improda, Giuliana Valerio

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Abstract

Background and aim: To assess the performance of Friedewald's and Sampson's formulas in relation to high or borderline-high levels of measured LDL-Cholesterol (LDL-C) in youths with overweight/obesity (OW/OB).

Methods and results: A cross-sectional study was performed in 1694 youths (age 5-17 years) with OW/OB observed in Italian centers of Messina (group 1) and Naples (group 2). LDL-C levels were both measured and calculated using Friedewald's (LDL-C_F) and Sampson's (LDL-C_S) formulas. The two groups were similar for sex, age, BMI, BMI Z-score, and measured LDL-C. Levels of LDL-C_F and LDL-C_S were higher in group 1 than group 2. In the overall sample, 9.9 % youths had measured LDL-C ≥130 mg/dL and 27.8 % ≥ 110 mg/dL, without differences between centers. The two formulas showed comparable high sensitivity and specificity in relation to levels of measured LDL-C ≥130 mg/dL or ≥110 mg/dL. However, LDL-C_F showed a higher positive predictive value than LDL-C_S.

Conclusions: Both formulas estimate with high accuracy measured LDL-C levels in youths with OW/OB. Therefore, calculated LDL-C can be a useful tool for universal screening when direct LDL-C measurement is not available. The Friedewald's formula is more feasible in clinical practice for simplicity of calculation.

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比较弗里德瓦尔德公式和桑普森公式对肥胖症青少年高水平低密度脂蛋白胆固醇测量值的估算。

背景和目的：评估弗里德瓦尔德（Friedewald）公式和桑普森（Sampson）公式在超重/肥胖（OW/OB）青少年高水平或接近高水平低密度脂蛋白胆固醇（LDL-C）测量中的表现：在意大利墨西拿（第1组）和那不勒斯（第2组）的中心对1694名超重/肥胖青少年（5-17岁）进行了横断面研究。采用弗里德瓦尔德（LDL-CF）和桑普森（LDL-CS）公式测量和计算了低密度脂蛋白胆固醇水平。两组的性别、年龄、体重指数、体重指数 Z 值和测量的低密度脂蛋白胆固醇水平相似。第一组的 LDL-CF 和 LDL-CS 水平高于第二组。在所有样本中，9.9% 的青少年测量的 LDL-C≥130 毫克/分升，27.8% 的青少年测量的 LDL-C≥110 毫克/分升，各中心之间没有差异。这两种公式对测量的低密度脂蛋白胆固醇水平≥130 毫克/分升或≥110 毫克/分升显示出相当高的灵敏度和特异性。然而，LDL-CF 的阳性预测值高于 LDL-CS：结论：两种计算公式都能非常准确地估算出 OW/OB 青少年的测量低密度脂蛋白胆固醇水平。因此，在无法直接测量低密度脂蛋白胆固醇的情况下，计算出的低密度脂蛋白胆固醇可作为一种有用的工具用于普遍筛查。在临床实践中，弗里德瓦尔德公式因计算简便而更为可行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.