Nutrition Metabolism and Cardiovascular Diseases最新文献

The time-averaged serum uric acid can better predict the prognosis of IgA nephropathy 时间平均血清尿酸能更好地预测 IgA 肾病的预后。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103800

Chenchen Qi , Xudong Liu , Jing Mao , Sen Zhang , Lan Ye , Xuan Wang , Jianan Peng , Xiaoling Zhou

Background and aim

To understand the clinical and pathological characteristics of patients with IgA nephropathy (IgAN) complicated by hyperuricemia, and to analyze the time-averaged SUA (TA-SUA) on the prognosis of IgAN.

Methods and results

A retrospective analysis of 718 IgAN patients with diagnosis confirmed by renal biopsy and follow-up of more than 1 year was performed. At least two serum uric acid (SUA) levels were measured at intervals of 0.5–1 year during follow-up. The TA-SUA was calculated according to the area under the curve during the follow-up period. The primary endpoint of the study was the doubling of creatinine or end-stage renal disease. Four groups (Q1-Q4) were divided according to TA-SUA quartile spacing from low to high, and the association of the TA-SUA with prognosis in IgAN patients was assessed using Kaplan-Meier survival analysis and Cox proportional hazards models.

This study included 718 patients with IgAN, of whom 181 (25.21 %) had hyperuricemia.Compared with the other three groups, the clinical and pathological characteristics of patients in the fourth quarter were more severe in both baseline SUA and TA-SUA groups. Multivariate results suggested that baseline SUA was not an independent risk factor for renal prognosis in IgAN patients after adjustment for clinical variables such as eGFR. High TA-SUA is an independent risk factor for renal prognosis in IgAN patients.

Conclusions

Hyperuricemia is common in IgA nephropathy.High TA-SUA in IgAN patients show more severe clinical features and pathological damage. TA-SUA is an independent risk factor for renal prognosis in IgA nephropathy patients.

背景和目的：了解并发高尿酸血症的IgA肾病（IgAN）患者的临床和病理特征，并分析时间平均SUA（TA-SUA）对IgAN预后的影响：对718名经肾活检确诊且随访超过1年的IgAN患者进行了回顾性分析。在随访期间，每隔 0.5-1 年至少测量两次血清尿酸 (SUA) 水平。根据随访期间的曲线下面积计算 TA-SUA。研究的主要终点是血肌酐翻倍或终末期肾病。根据TA-SUA四分位距从低到高分为四组（Q1-Q4），并使用卡普兰-梅耶生存分析和考克斯比例危险模型评估TA-SUA与IgAN患者预后的关系。这项研究共纳入了718名IgAN患者，其中181人（25.21%）患有高尿酸血症。与其他三组患者相比，基线SUA组和TA-SUA组第四季度患者的临床和病理特征都更为严重。多变量结果表明，在调整了eGFR等临床变量后，基线SUA并不是影响IgAN患者肾脏预后的独立危险因素。高TA-SUA是IgAN患者肾脏预后的独立危险因素：高尿酸血症在IgA肾病中很常见，高TA-SUA在IgAN患者中表现出更严重的临床特征和病理损伤。TA-SUA是影响IgA肾病患者肾脏预后的独立危险因素。

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引用次数: 0

The bone-heart axis in the pathogenesis of cardiovascular diseases: A narrative review

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2025.103872

Anita Vergatti , Veronica Abate , Gabriella Iannuzzo , Antonio Barbato , Gianpaolo De Filippo , Domenico Rendina

Cardiovascular diseases (CVDs) cause about 30% of deaths worldwide, increasing social and economic burden in our societies. Although the treatment of the canonical cardiovascular risk factors has reduced the impact of CVDs on morbidity and mortality in the past few years, they continue to represent a major health problem. The definition of the biological properties of the bone-heart axis has led to new insights in the pathogenesis of CVDs; hence, the aim of this review is to try to elucidate the role of this axis on the susceptibility to CVDs. There is evidence that the bone interacts with extra-skeletal organs, including the cardiovascular system, through its endocrine functions. Clinical and experimental data strongly indicate that the interplay between the bone and the cardiovascular system represents a future tool for the prevention, diagnosis and treatment of CVDs. The identification of these non-canonical cardiovascular risk factors could prompt pharmacological research towards new target therapy aimed at precision medicine.

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引用次数: 0

Abdominal obesity: A lethal factor in elderly male osteoporosis patients – insights from NHANES 腹部肥胖：老年男性骨质疏松症患者的致死因素——来自NHANES的见解。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103788

Ziyao Ding , Xinzhe Qu , Qirui Zhu , Jinlong Tang , Zhengya Zhu , Changchang Chen , Fuchao Chu , Maji Sun , Feng Yuan

Background and aim

This study aims to investigate the relationship between A Body Shape Index (ABSI) Z-score and all-cause mortality among osteoporotic patients using data from the National Health and Nutrition Examination Survey (NHANES).

Methods and results

We analyzed NHANES data from 2005 to 2010, 2013 to 2014, and 2017 to 2018, focusing on individuals aged 50 and above with complete bone mineral density (BMD) data. The ABSI Z-score, calculated by adjusting waist circumference (WC) for height and weight, was used to independently assess abdominal fat beyond Body Mass Index (BMI). Mortality status was confirmed by linking NHANES data with the National Death Index (NDI), with follow-up until December 31, 2019. Weighted Cox proportional hazards models were employed for analysis, adjusting for age, gender, race, fracture history, anti-osteoporosis treatment history, diabetes, and cardiovascular disease (CVD). The study included 1596 participants. Higher ABSI Z-scores were significantly associated with increased all-cause mortality risk, especially among elderly male osteoporotic patients. This association remained robust after adjusting for multiple potential confounders.

Conclusion

The ABSI Z-score serves as a valuable non-invasive screening tool that effectively identifies osteoporotic patients at higher risk of mortality. These findings emphasize the importance of body management in health, supporting further research to explore the practical utility of ABSI Z-score in osteoporotic patients and how body management can enhance long-term survival rates.

背景与目的：本研究旨在利用国家健康与营养调查（NHANES）的数据，探讨骨质疏松症患者A体型指数（ABSI） Z-score与全因死亡率的关系。方法与结果：我们分析了2005 - 2010年、2013 - 2014年和2017 - 2018年的NHANES数据，重点研究了50岁及以上、骨密度（BMD）数据完整的个体。通过调整身高和体重的腰围（WC）来计算ABSI Z-score，用于独立评估身体质量指数（BMI）以外的腹部脂肪。通过将NHANES数据与国家死亡指数（NDI）联系起来，并随访至2019年12月31日，确认了死亡状况。采用加权Cox比例风险模型进行分析，调整了年龄、性别、种族、骨折史、抗骨质疏松治疗史、糖尿病和心血管疾病（CVD）等因素。该研究包括1596名参与者。较高的ABSI z评分与全因死亡风险增加显著相关，尤其是老年男性骨质疏松患者。在对多个潜在混杂因素进行调整后，这种关联仍然很强。结论：ABSI Z-score是一种有价值的非侵入性筛查工具，可有效识别骨质疏松症患者的高死亡率。这些发现强调了身体管理对健康的重要性，支持进一步研究ABSI Z-score在骨质疏松患者中的实际应用，以及身体管理如何提高长期生存率。

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引用次数: 0

Mediating effect of physical activity on the relationship between high dietary live microbe intake and obesity among U.S adolescents, finding from NHANES 1999–2018 体育锻炼对美国青少年高膳食活微生物摄入量与肥胖之间关系的中介效应，来自 NHANES 1999-2018 年的研究结果。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103786

Jing-hong Liang , Ying-qi Pu , Xiu-zhi Yang, Jia-qi Chen, Zhuo-wen Wu, Mei-ling Liu, Nan Jiang, Shan Huang, Yu-shan Zhang, Li-xin Hu, Zheng-ge Jin, Wen-xin Ge, Xue-ya Pu, Shao-yi Huang, Ya-jun Chen

Background and aims

The impact of dietary live microbe intake on adolescent obesity is still not fully understood. This study aims to investigate the potential relationship between dietary live microbe intake and obesity among U.S adolescents, and to explore the mediating role of physical activity (PA).

Methods and results

Data from NHANES (1999–2018) were analyzed, and dietary live microbe intake was categorized into low, medium, and high groups using a developed framework. Survey-weighted logistic regression and mediation analysis models were used to examine the association between live microbe intake and adolescent obesity, as well as the potential mediating effect of PA. Our study included 8443 participants aged 6–18, representing the noninstitutionalized U.S population of 184.5 million. We found that participants with a high dietary intake of live microbes had lower odds of developing obesity compared to those with the lowest exposure to live microbes (AOR = 0.900, 95 % CI: 0.812, 0.997). Additionally, our mediation analysis revealed a significant indirect effect of live microbes on obesity risk through PA (P-value <0.001), with 39.4 % (95 % CI: 24.5 %, 86.5 %) of the effect mediated by PA.

Conclusion

Our study highlights the association between consuming a higher amount of live microbes in the diet and a decreased risk of obesity among U.S adolescents. It also suggests that PA may act as a mediator in this relationship. Therefore, it is crucial to emphasize the incorporation of both dietary interventions and PA in the development of prevention and therapy policies for managing adolescent obesity.

背景和目的：膳食中活微生物的摄入量对青少年肥胖的影响尚未完全明了。本研究旨在调查美国青少年膳食活微生物摄入量与肥胖之间的潜在关系，并探讨体育活动（PA）的中介作用：分析了美国国家健康调查（NHANES）（1999-2018 年）的数据，并利用开发的框架将膳食活微生物摄入量分为低、中、高三组。采用调查加权逻辑回归和中介分析模型来研究活微生物摄入量与青少年肥胖之间的关系，以及PA的潜在中介效应。我们的研究包括 8443 名 6-18 岁的参与者，代表了美国 1.845 亿非住院人口。我们发现，与接触活微生物最少的人相比，从饮食中摄入大量活微生物的人患肥胖症的几率较低（AOR = 0.900，95 % CI：0.812，0.997）。此外，我们的中介分析表明，活微生物通过PA对肥胖风险有显著的间接影响（P值结论：活微生物对肥胖风险有显著的间接影响：我们的研究强调了在饮食中摄入更多的活微生物与降低美国青少年肥胖风险之间的关系。研究还表明，PA 可能是这一关系的中介。因此，在制定青少年肥胖症的预防和治疗政策时，必须强调将饮食干预和活动量纳入其中。

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引用次数: 0

LP(a): The new marker of high cardiovascular risk

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103845

Maurizio Averna , Angelo B. Cefalù

The biological functions and role in human diseases of lipoprotein (a) discovered more than 60 years ago are still not fully understood. The high homology of apo(a) with plasminogen initially leads us to think of Lp(a) as a player in the coagulation system as pro-thrombotic factor. Over the years, a solid body of evidence from biology, epidemiology and from genetics and mendelian randomization has contributed to identify Lp(a) as a causal factor of atherosclerotic coronary heart disease, aortic calcific valve stenosis and ischaemic stroke. The active involvement of Lp(a) in atherogenesis and aortic calcific valve stenosis has been demonstrated by experimental data regarding the role of oxidized phospholipids, which are the cargo of Lp(a) and the presence of a Lp(a) receptor in valve interstitial cells. In secondary prevention, patients optimally treated for low density lipoprotein cholesterol (LDL-C) but with high Lp(a) levels show a residual cardiovascular risk. To date the LDL-C affecting drugs have a marginal effect on Lp(a). Statins produce a modest increase, monoclonal PCSK9i and Inclisiran a modest decrease not sufficient to reduce significantly the risk associated to Lp(a). Only lipoprotein apheresis and obicetrapib, a CETP novel inhibitor, reduce respectively by 75% and 40% Lp(a) levels. To obtain a lifetime risk reduction of 50% similar to that achieved by reducing LDL-C of about 40 mg/dl, Lp(a) should be reduced of about 100 mg/dl. The ongoing trials on drugs such as ASO, SiRnas, assembly inhibitors and maybe in the future the gene editing could obtain these results.

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引用次数: 0

Distinct metabolites in atherosclerosis based on metabolomics: A systematic review and meta-analysis primarily in Chinese population 基于代谢组学的动脉粥样硬化中的不同代谢物：主要针对中国人群的系统综述和荟萃分析

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103789

Jinlin Tong , Xu Han , Yuanyuan Li , Yuyao Wang , Meijie Liu , Hong Liu , Jinghua Pan , Lei Zhang , Ying Liu , Miao Jiang , Hongyan Zhao

Aims

Atherosclerosis is a life-threatening disease that develops when a plaque builds up inside an artery and progresses silently. Identifying the early pathological changes and the biomarkers of atherosclerosis deserves attention. We aimed to systematically study and integrate the various metabolites of atherosclerosis in the level of disease to provide more evidences to support early prevention and treatment of atherosclerosis.

Data synthesis

The protocol was registered with PROPSERO (CRD42023441845). We searched 14,985 records via EMBASE, PubMed, Web of Science, WanFang data, VIP data, and CNKI databases. The collected metabolites were for qualitative and quantitative meta-analysis. The I² statistic estimated heterogeneity, with over 50 % considered to adopt the random-effects model. A total of 49 articles were included in the meta-analysis. We finally integrated 83 and 16 metabolites presented more than two times in inclusion studies, respectively in blood (plasma and serum) and urine. Among them, the level of citric acid (SMD = −10.35 [95%CI -15.03, −5.67], p < 0.001), lactic acid (SMD = 6.32 [95%CI 0.12, 12.52], p < 0.001) and TMAO (SMD = 1.40 [95%CI 0.27, 2.53], p < 0.001) had significant differences between atherosclerosis and controls. And we observed blood stasis syndrome of atherosclerosis patients present arterial ischemia and energy disorder obviously.

Conclusions

The study provides an in-depth understanding of the roles of metabolites on atherosclerosis progression and prediction primarily in Chinese population, which contributing to development of prevention and therapeutic potential in the future.

目的：动脉粥样硬化是一种危及生命的疾病，当斑块在动脉内形成并悄无声息地发展时就会发生。鉴别动脉粥样硬化的早期病理变化和生物标志物值得重视。我们旨在系统地研究和整合动脉粥样硬化在疾病层面的各种代谢物，为动脉粥样硬化的早期预防和治疗提供更多证据。数据综合：该协议在PROPSERO注册（CRD42023441845）。通过EMBASE、PubMed、Web of Science、万方数据、VIP数据、中国知网等数据库检索14985条记录。收集的代谢物进行定性和定量荟萃分析。I2统计量估计异质性，超过50%被认为采用随机效应模型。meta分析共纳入49篇文章。我们最终整合了83个和16个在纳入研究中出现两次以上的代谢物，分别在血液（血浆和血清）和尿液中。其中，柠檬酸水平（SMD = -10.35 [95%CI -15.03, -5.67], p）。结论：本研究主要在中国人群中深入了解代谢物在动脉粥样硬化进展和预测中的作用，有助于未来预防和治疗潜力的开发。

{"title":"Distinct metabolites in atherosclerosis based on metabolomics: A systematic review and meta-analysis primarily in Chinese population","authors":"Jinlin Tong , Xu Han , Yuanyuan Li , Yuyao Wang , Meijie Liu , Hong Liu , Jinghua Pan , Lei Zhang , Ying Liu , Miao Jiang , Hongyan Zhao","doi":"10.1016/j.numecd.2024.103789","DOIUrl":"10.1016/j.numecd.2024.103789","url":null,"abstract":"<div><h3>Aims</h3><div>Atherosclerosis is a life-threatening disease that develops when a plaque builds up inside an artery and progresses silently. Identifying the early pathological changes and the biomarkers of atherosclerosis deserves attention. We aimed to systematically study and integrate the various metabolites of atherosclerosis in the level of disease to provide more evidences to support early prevention and treatment of atherosclerosis.</div></div><div><h3>Data synthesis</h3><div>The protocol was registered with PROPSERO (CRD42023441845). We searched 14,985 records via EMBASE, PubMed, Web of Science, WanFang data, VIP data, and CNKI databases. The collected metabolites were for qualitative and quantitative meta-analysis. The I<sup>2</sup> statistic estimated heterogeneity, with over 50 % considered to adopt the random-effects model. A total of 49 articles were included in the meta-analysis. We finally integrated 83 and 16 metabolites presented more than two times in inclusion studies, respectively in blood (plasma and serum) and urine. Among them, the level of citric acid (SMD = −10.35 [95%CI -15.03, −5.67], p < 0.001), lactic acid (SMD = 6.32 [95%CI 0.12, 12.52], p < 0.001) and TMAO (SMD = 1.40 [95%CI 0.27, 2.53], p < 0.001) had significant differences between atherosclerosis and controls. And we observed blood stasis syndrome of atherosclerosis patients present arterial ischemia and energy disorder obviously.</div></div><div><h3>Conclusions</h3><div>The study provides an in-depth understanding of the roles of metabolites on atherosclerosis progression and prediction primarily in Chinese population, which contributing to development of prevention and therapeutic potential in the future.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 3","pages":"Article 103789"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MAFLD as a predictor of adverse cardiovascular events among CHD patients with LDL-C<1.8 mmol/L MAFLD 作为低密度脂蛋白胆固醇<1.8 mmol/L 的冠心病患者不良心血管事件的预测因子。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103798

Jingjing Song , Yupeng Liu , Ye Liu , Ying Liu , Qing Zhou , Jing Chen , Xiangbin Meng , Wenyao Wang , Yi-Da Tang

Background and aims

Patients receiving statin therapy still suffer from adverse cardiovascular events. Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is a newly proposed concept that shares common metabolic risk factors with cardiovascular disease. This study aimed to investigate the association between MAFLD and adverse cardiovascular outcomes in coronary heart disease (CHD) patients with LDL-C<1.8 mmol/L.

Methods and results

CHD patients with LDL-C<1.8 mmol/L were divided into MAFLD and non-MAFLD groups. Propensity score matching (PSM) was used to control for baseline differences between the two groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs). All MAFLD patients were further stratified into two groups with and without advanced liver fibrosis, according to the Fibrosis-4 (FIB-4) index cutoffs, and the associations between advanced liver fibrosis status and cardiovascular outcomes were analyzed. After PSM, 800 MAFLD and 800 non-MAFLD patients with LDL-C<1.8 mmol/L were analyzed. MAFLD patients exhibited a significantly greater cumulative incidence and risk of MACCEs than non-MAFLD patients (9.6 % versus 6.6 %, p < 0.05; HR 1.48, 95 % CI 1.04–2.1, p < 0.05). Among MAFLD patients with LDL-C<1.8 mmol/L, advanced liver fibrosis staged by the FIB-4 index was associated with an elevated risk for MACCEs (HR 2.91, 95 % CI 1.17–7.19, p < 0.05), all-cause mortality, myocardial infarction (MI) and stent thrombosis.

Conclusion

MAFLD was an independent risk factor for adverse cardiovascular outcomes in CHD patients with LDL-C<1.8 mmol/L. Additionally, advanced liver fibrosis predicts increased risks for adverse cardiovascular events among MAFLD patients. These findings suggest that MAFLD and liver fibrosis screening and management contribute to the residual cardiovascular risk of CHD patients.

背景和目的：接受他汀类药物治疗的患者仍存在不良心血管事件。代谢（功能障碍）相关脂肪肝（MAFLD）是一个新提出的概念，它与心血管疾病具有共同的代谢危险因素。本研究旨在探讨冠心病（冠心病）伴LDL-C患者中MAFLD与心血管不良结局的关系。方法和结果：冠心病伴LDL-C患者。结论：MAFLD是冠心病伴LDL-C患者心血管不良结局的独立危险因素

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引用次数: 0

Long-term impact of socioeconomic status after acute myocardial infarction in Korea 韩国急性心肌梗死后社会经济状况的长期影响。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.08.022

Hoyoun Won , Yong-Hoon Kim , Jeongsook Kim , Yonghwan Kim , Hee-Taik Kang

Background and aims

Socioeconomic status (SES) is known to impact the prognosis of acute myocardial infarction (AMI). However, due to the limited scope of previous studies, this study aimed to investigate the impact of SES on the prognosis of AMI patients within the Korean national healthcare insurance system.

Methods and results

A retrospective cohort study included patients who were diagnosed with AMI between 2007 and 2008 from the Korean National Health Insurance Service and underwent a national health check-up program. Primary endpoint was all-cause mortality. The median follow-up duration was 13.5 years. The SES was divided into tertile scale based on insurance premiums and economic status. Tertile 1 (T1) was the lowest SES, and tertile 3 (T3) was the highest SES. A total of 5971 patients were included, of whom 4329 were employed insured (EI), and 1642 were self-employed insured (SI). After adjusted confounding variables, the Cox-regression model showed SI was associated with worse outcome compared with EI (hazard ratio (HR) [95 % confidence intervals (CIs)], 1.11 [1.02−1.22]). Among individuals in EI, lower economic status showed a trend of worse outcome, but it was not significant (lower tertile vs. higher tertile group, HR [95 % CIs], 1.01 [0.88−1.14]). However, compared with T3 in SI, HRs (95 % CIs) for all-cause death in T2 and T1 were 1.33 (1.09−1.63) and 1.34 (1.10−1.64), respectively.

Conclusion

SES significantly affected the long-term outcome in patients with AMI. SI and lower economic status in SI were associated with a higher mortality rate than EI and higher economic status, respectively. Further investigation of the underlying role of SES in increased mortality after AMI is warranted.

背景和目的：众所周知，社会经济地位（SES）会影响急性心肌梗死（AMI）的预后。然而，由于之前的研究范围有限，本研究旨在调查社会经济地位对韩国国家医疗保险体系内急性心肌梗死患者预后的影响：这项回顾性队列研究纳入了 2007 年至 2008 年期间在韩国国民健康保险服务中被诊断为急性心肌梗死并接受国民健康体检项目的患者。主要终点是全因死亡率。中位随访时间为 13.5 年。SES根据保险费和经济状况划分为三等分。第 1 层（T1）为最低社会经济地位，第 3 层（T3）为最高社会经济地位。共纳入了 5971 名患者，其中 4329 人为受雇保险人（EI），1642 人为自雇保险人（SI）。经调整混杂变量后，Cox 回归模型显示，与 EI 相比，SI 与较差的预后相关（危险比 (HR) [95 % 置信区间 (CIs)]，1.11 [1.02-1.22]）。在 EI 患者中，经济地位较低者的预后有变差的趋势，但并不显著（较低三分位组与较高三分位组相比，HR [95 % 置信区间 (CIs)]，1.01 [0.88-1.14]）。然而，与SI的T3相比，T2和T1的全因死亡HRs（95 % CIs）分别为1.33（1.09-1.63）和1.34（1.10-1.64）：结论：社会经济地位对急性心肌梗死患者的长期预后有重要影响。结论：社会经济地位对急性心肌梗死患者的长期预后有重要影响。与经济地位较高和经济地位较低的患者相比，经济地位较高和经济地位较低的患者的死亡率较高。有必要进一步研究 SES 在急性心肌梗死后死亡率增加中的潜在作用。

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引用次数: 0

Impact of dietary inflammatory index on cardiometabolic, endocrine, liver, renal, and bone biomarkers 膳食炎症指数对心脏代谢、内分泌、肝脏、肾脏和骨骼生物标志物的影响。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103793

Jiaxu Wang, Jigong Wu, Liqi Li

引用次数: 0

Is the triglyceride-glucose index ready for cardiovascular risk assessment?

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-01 DOI: 10.1016/j.numecd.2024.103834

Lanfranco D'Elia

Aims

Insulin resistance is a major risk factor for cardiovascular disease. Thus, early identification of insulin resistance is important for classifying individuals at high cardiovascular risk. All the tools commonly used in epidemiological studies and clinical practice to assess insulin resistance require measuring insulin levels, which is a limitation. Hence, simpler methods have been proposed to overcome these limitations. One of the most promising is the triglyceride-glucose index.

Therefore, this narrative review focuses on the most significant epidemiological findings concerning the relationship between the triglyceride-glucose index and cardiovascular risk. Furthermore, it also highlights this new tool's strengths, limitations, and perspectives for assessing cardiovascular risk.

Data synthesis

Even though the assessment of this index is relatively recent, there are numerous papers on this topic, and their number is constantly increasing. Observational studies have shown a substantial positive association between the triglyceride-glucose index and cardiovascular risk, although some conflicting results have been observed.

Conclusions

The index is strongly associated with cardiovascular mortality and cardiovascular risk factors. However, some gaps need to be addressed.

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引用次数: 0