Nutrition Metabolism and Cardiovascular Diseases最新文献

SPECIAL ISSUE ON ONE HEALTH Guest Editors Prof.Giovanni Targher (University of Verona School of Medicine and Surgery,Italy) Dr.Frida Leonetti (Università di Roma La Sapienza, Italy) Prof. Ferruccio Galletti (University of Naples FedericoII,Napoli, Italy) 特刊ON ONE HEALTH特刊特邀编辑giovanni Targher教授（意大利维罗纳大学医学和外科学院）frida Leonetti博士（意大利罗马大学）Ferruccio Galletti教授（意大利那不勒斯FedericoII大学）

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-04-25 DOI: 10.1016/S0939-4753(25)00231-5

引用次数: 0

Phase angle is associated with inflammatory parameters in young adults and adults with metabolic syndrome in a population-based study 在一项基于人群的研究中，相位角与年轻人和代谢综合征成年人的炎症参数相关。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-29 DOI: 10.1016/j.numecd.2025.104028

Mariana P. Gabiatti, Giana Z. Longo, Daniela B. Hauschild, Luiza G. Pinto, Fernanda Hansen

Background and aims

Phase angle (PhA) is suggested to reflect cell health. PhA association with inflammation and adiposity in metabolic syndrome (MetS) presence or absence, remains unclear. In the general population, PhA association with C-reactive protein (CRP) is controversial, and studies on PhA with other inflammatory markers are a literature gap. This study aims to evaluate the association of PhA with inflammatory and adiposity-related parameters in males and females with and without MetS.

Methods and results

Cross-sectional study with 597 adults (38.4 years; CI95 % 36.35–40.45) categorized into MetS (n = 126, 57.9 % female) and non-MetS (n = 471, 55.2 % female). Single-frequency bioimpedance analysis evaluated PhA. Adiposity-related (BMI, visceral adiposity index, and body fat percentage (%BF) by dual-energy x-ray emission) and serum inflammatory parameters (CRP, TNF-α, IL-6, IL-10, IL-1β, IL-8, IL-12p70) were evaluated. Regression analyses adjusted by age, and physical activity level, with or without %BF, evaluated the associations. In males MetS, PhA was negatively associated with %BF, IL-6, IL-10, IL-1β, and IL-12p70 (β = −0.07, p = 0.005, β = −0.03, p = 0.035, β = −0.06, p = 0.006, β = −0.03, p = 0.048, β = −0.02, p = 0.038, respectively) and positively associated with BMI (β = 0.07, p = 0.003) in non-MetS. In females MetS, PhA was negatively associated with TNF-α and IL-12p70 (β = −0.02, p = 0.048, β = −0.01, p = 0.016, respectively) and positively with IMC, %BF, TNF-α and IL-8 (β = 0.07, p < 0.001, β = 0.02, p = 0.021, β = 0.02, p = 0.011, β = 0.01, p = 0.035, respectively) in non-MetS.

Conclusion

In MetS individuals, higher PhA values are associated with lower inflammatory parameters in both sexes and %BF in males. The different behavior of PhA in females, suggests caution when interpreting PhA in this population.

背景与目的：建议用相位角（PhA）来反映细胞的健康状况。PhA与代谢综合征（MetS）存在或不存在的炎症和肥胖的关系尚不清楚。在一般人群中，PhA与c反应蛋白（CRP）的相关性存在争议，而PhA与其他炎症标志物的研究也是文献空白。这项研究的目的是评估PhA与炎症和肥胖相关参数在男性和女性有和没有MetS的关系。方法和结果：横断面研究597名成人(38.4岁；CI95 %（36.35 ~ 40.45）分为MetS （n = 126，女性占57.9%）和non-MetS （n = 471，女性占55.2%）。单频生物阻抗分析评价PhA。评估肥胖相关指标（BMI、内脏脂肪指数、双能x线放射体脂率%BF）和血清炎症参数（CRP、TNF-α、IL-6、IL-10、IL-1β、IL-8、IL-12p70）。根据年龄和体力活动水平调整的回归分析，有或没有%BF，评估相关性。在男性大都会,PhA是负相关的% BF, il - 6、il - 10、il - 1β,和IL-12p70(β= -0.07,p = 0.005,β= -0.03,p = 0.035,β= -0.06,p = 0.006,β= -0.03,p = 0.048,β= -0.02,p = 0.038)和与BMI呈正相关(β= 0.07,p = 0.003) non-MetS。在女性met中，PhA与TNF-α和IL-12p70呈负相关（β = -0.02, p = 0.048, β = -0.01, p = 0.016），与IMC、%BF、TNF-α和IL-8呈正相关（β = 0.07, p）。结论：在met个体中，较高的PhA值与两性较低的炎症参数和男性较低的BF有关。PhA在女性中的不同表现，提示在解释这一人群中的PhA时要谨慎。

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引用次数: 0

Global cardiovascular disease burden attributable to high low-density lipoprotein cholesterol, 1990–2021: An age-period-cohort analysis of the global burden of disease study 2021 1990-2021年由高低密度脂蛋白胆固醇引起的全球心血管疾病负担：2021年全球疾病负担研究的年龄期队列分析

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-27 DOI: 10.1016/j.numecd.2025.104030

Yangyu Zhao , Lei Chen , Jiayang Dong , Xinyue Yang , Tenglong Hu , Na Sun , Qiang Sun , Wenyan Liang , Xiqing Wei , Zhiqiang Zhang

Background and aims

To deepen the understanding of global trends in the cardiovascular disease (CVD) burden attributed to high low-density lipoprotein cholesterol (LDL-C).

Methods and results

Utilizing data from the Global Burden of Disease study spanning from 1990 to 2021, an age-period-cohort analysis was conducted to evaluate global trends in mortality and disability-adjusted life years (DALYs) of CVD attributed to high LDL-C. Joinpoint regression analysis was employed to identify periods of the most significant changes. The findings indicate a significant increase in the global number of deaths from CVD linked to high LDL-C from 1990 to 2021. However, both the age-standardized mortality rate and DALYs rate exhibited a downward trend, with women experiencing a more pronounced decline than men. The age-standardized rate was lower in countries with higher Socio-demographic Index (SDI) compared to those with lower SDI. Notably, there were significant reductions in CVD mortality during the periods of 1994–1998 and 2003–2007.

Conclusion

This study underscores the critical role of high LDL-C as a risk factor in the global burden of CVD. Investigating gender differences, regional disparities, and variations among different age groups of CVD is essential for developing intervention strategies and health policies.

背景和目的：加深对高低密度脂蛋白胆固醇（LDL-C）引起的心血管疾病（CVD）负担的全球趋势的理解。方法和结果：利用1990年至2021年全球疾病负担研究的数据，进行了年龄期队列分析，以评估由高LDL-C引起的CVD死亡率和残疾调整生命年（DALYs）的全球趋势。采用联合点回归分析来确定最显著变化的时期。研究结果表明，从1990年到2021年，全球与高LDL-C相关的心血管疾病死亡人数显著增加。然而，年龄标准化死亡率和伤残调整生命年都呈现下降趋势，妇女的下降幅度比男子更明显。在社会人口指数（SDI）较高的国家，年龄标准化率低于SDI较低的国家。值得注意的是，在1994-1998年和2003-2007年期间，心血管疾病死亡率显著下降。结论：本研究强调了高LDL-C作为全球心血管疾病负担的危险因素的关键作用。调查心血管疾病的性别差异、地区差异和不同年龄组之间的差异对于制定干预策略和卫生政策至关重要。

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引用次数: 0

Association between remnant cholesterol and arterial stiffness: Evidence from NHANES 1999-2018. 残余胆固醇与动脉硬化之间的关系：来自NHANES 1999-2018的证据。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-27 DOI: 10.1016/j.numecd.2025.104013

Tianjie Lai, Yiyin Liang, Fenglei Guan, Yunxian Chen, Konghe Hu

Background and aim: Remnant cholesterol (RC), an emerging cardiovascular risk factor, has garnered increasing attention in atherosclerotic cardiovascular disease (ASCVD) research, though its relationship with arterial stiffness remains incompletely understood. This study investigated the association between RC and estimated pulse wave velocity (ePWV), a reliable marker of arterial stiffness, with the goal of enhancing our understanding of RC's role in cardiovascular risk assessment.

Methods and results: This study utilized the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018, including 12,505 participants aged 20 years and above. Weighted linear regression, restricted cubic splines (RCS), and subgroup analyses were used to explore the association between RC levels and ePWV. Analysis revealed a significant positive association between RC levels and ePWV, with participants in the highest RC quintile (Q5) exhibiting substantially elevated ePWV compared to those in the lowest quintile (Q1). Notably, RCS analysis demonstrated a non-linear relationship characterized by a saturation effect (p-nonlinear <0.05). Subgroup analyses indicated stronger associations among specific demographic groups, including individuals under 40 years, females, non-Hispanic whites, and those above the poverty level (all interaction p < 0.05). Furthermore, mediation analysis found that various inflammatory markers such as neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) played a mediating role in this association.

Conclusion: Increased arterial stiffness is associated with higher RC levels, demonstrating a saturation effect at elevated concentrations. This association is partially mediated by NLR, MLR, and NEU, and was stronger among younger, females, non-Hispanic whites, and non-impoverished individuals.

背景和目的：残余胆固醇（RC）是一种新兴的心血管危险因素，在动脉粥样硬化性心血管疾病（ASCVD）研究中引起了越来越多的关注，尽管其与动脉硬度的关系仍未完全了解。本研究探讨了RC与估计脉搏波速度（ePWV）之间的关系，ePWV是动脉僵硬度的可靠标志，目的是增强我们对RC在心血管风险评估中的作用的理解。方法与结果：本研究利用1999年至2018年美国国家健康与营养检查调查（NHANES）的数据，包括12505名20岁及以上的参与者。采用加权线性回归、受限三次样条（RCS）和亚组分析来探讨RC水平与ePWV之间的关系。分析显示，RC水平与ePWV之间存在显著正相关，与最低五分位数（Q1）的参与者相比，最高RC五分位数（Q5）的参与者表现出显著升高的ePWV。值得注意的是，RCS分析显示了以饱和效应为特征的非线性关系(p-非线性结论：动脉刚度增加与较高的RC水平相关，表明浓度升高时存在饱和效应。这种关联部分由NLR、MLR和NEU介导，并且在年轻人、女性、非西班牙裔白人和非贫困个体中更为强烈。

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引用次数: 0

Causal relationship between serum 25-hydroxyvitamin D and coronary heart disease: A bi-directional two-sample Mendelian randomization study 血清25-羟基维生素D与冠心病的因果关系：一项双向双样本孟德尔随机研究

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-26 DOI: 10.1016/j.numecd.2025.104020

Xingping Li , Wenqing Wang , Huanyu Liu , Ronghui Xia , Yang Lin , Guanghui Pan

Background and aim

Coronary heart disease (CHD) is the leading cause of severe cardiovascular events, such as acute myocardial infarction. This study investigates the interaction between serum 25-hydroxyvitamin D (25(OH)D) levels and CHD. However, most current studies are observational, which may introduce bias into the results.

Methods and results

We conducted a two-way, two-sample Mendelian randomization study. The CHD sample was drawn from the 2021 population in the FinnGen database (cases: 21,012; controls: 197,780), while the serum 25(OH)D sample was obtained from the 2020 European population in the GWAS Catalog database (417,580 cases). Based on the inverse variance weighted (IVW) results, we found that the risk of CHD decreased with increasing serum 25(OH)D concentrations (P < 0.05), and that higher CHD risk was associated with lower serum 25(OH)D concentrations (P = 0.04).

Conclusions

Our study found that increased serum 25(OH)D concentration may serve as a protective factor against CHD. Additionally, we found that CHD can be a risk factor that affects serum 25(OH)D concentrations in humans.

背景与目的：冠心病（CHD）是急性心肌梗死等严重心血管事件的主要原因。本研究探讨血清25-羟基维生素D （25(OH)D）水平与冠心病的相互作用。然而，目前大多数研究都是观察性的，这可能会给结果带来偏见。方法与结果：我们进行了一项双向、双样本孟德尔随机化研究。冠心病样本来自FinnGen数据库中的2021年人群(病例：21,012例；对照组：197,780例)，而血清25(OH)D样本来自GWAS目录数据库中的2020年欧洲人群（417,580例）。根据逆方差加权（IVW）结果，我们发现随着血清25(OH)D浓度的升高，冠心病的风险降低(P)。结论：我们的研究发现血清25(OH)D浓度升高可能是预防冠心病的保护因素。此外，我们发现冠心病可能是影响人类血清25(OH)D浓度的危险因素。

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引用次数: 0

Serum uric acid fluctuations and cardiovascular outcomes in hospitalized acute heart failure patients 急性心力衰竭住院患者血清尿酸波动与心血管预后

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-24 DOI: 10.1016/j.numecd.2025.104025

Guang-Zhi Liao , Jia-Yu Feng , Jing-Xi Wang , Ping Zhou , Chun-Hui He , Xiao-Feng Zhuang , Yan Huang , Qiong Zhou , Mei Zhai , Yu-Hui Zhang , Jian Zhang

Background and aims

This study examined the association between serum uric acid (SUA) fluctuation patterns during hospitalization in acute heart failure (HF) patients and clinical outcomes, a relationship not fully understood.

Methods and results

A cohort of 1403 acute HF patients was enrolled with a median follow-up of 20.5 months. Outcomes assessed included cardiovascular (CV) death and/or heart failure hospitalization (CV death & HHP), CV death alone, and all-cause mortality (ACM). Restricted cubic splines analyzed the relationship between admission SUA levels and outcomes. Patients were categorized based on admission and discharge SUA levels into four groups: 1) Normal SUA at both points (N&N), 2) Elevated SUA at admission, normalized at discharge (H&N), 3) Normal SUA at admission, elevated at discharge (N&H), and 4) Elevated SUA at both points (H&H). Associations between SUA categories and outcomes were assessed using COX multivariate regression analysis. Results showed elevated SUA at admission predicted poor outcomes. However, neither N&H nor H&N groups displayed significant increases in CV death & HHP, CV death, or ACM compared to N&N. The H&H group had the highest risks for CV death (adjusted HR 1.79, 95 % CI 1.10–2.93) and ACM (adjusted HR 1.64, 95 % CI 1.08–2.49), with a non-significant trend towards increased risk of CV death & HHP (adjusted HR 1.79, 95 % CI 0.99–2.93).

Conclusion

Persistently elevated SUA levels during hospitalization were independently associated with adverse cardiovascular outcomes and ACM in patients with acute HF, whereas fluctuations in SUA levels did not exhibit a similar association.

背景和目的：本研究探讨急性心力衰竭（HF）患者住院期间血清尿酸（SUA）波动模式与临床结果之间的关系，这种关系尚未完全了解。方法和结果：1403例急性心衰患者入组，中位随访20.5个月。评估的结局包括心血管（CV）死亡和/或心力衰竭住院（CV死亡和HHP）、CV单独死亡和全因死亡率（ACM）。限制三次样条分析了入院SUA水平与预后之间的关系。根据患者入院和出院时的SUA水平将患者分为4组：1)两点SUA正常（N&N）， 2)入院时SUA升高，出院时正常化（H&N）， 3)入院时SUA正常，出院时升高（N&H）， 4)两点SUA升高（H&H）。采用COX多元回归分析评估SUA类别与结果之间的关系。结果显示，入院时SUA升高预示预后不良。然而，与N&N组相比，N&H组和H&N组的CV死亡率和HHP、CV死亡率或ACM均没有显著增加。H&H组的CV死亡风险最高（校正HR 1.79, 95% CI 1.10-2.93）， ACM（校正HR 1.64, 95% CI 1.08-2.49）， CV死亡和HHP（校正HR 1.79, 95% CI 0.99-2.93）的风险增加趋势不显著。结论：住院期间持续升高的SUA水平与急性HF患者的不良心血管结局和ACM独立相关，而SUA水平的波动没有表现出类似的关联。

{"title":"Serum uric acid fluctuations and cardiovascular outcomes in hospitalized acute heart failure patients","authors":"Guang-Zhi Liao , Jia-Yu Feng , Jing-Xi Wang , Ping Zhou , Chun-Hui He , Xiao-Feng Zhuang , Yan Huang , Qiong Zhou , Mei Zhai , Yu-Hui Zhang , Jian Zhang","doi":"10.1016/j.numecd.2025.104025","DOIUrl":"10.1016/j.numecd.2025.104025","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study examined the association between serum uric acid (SUA) fluctuation patterns during hospitalization in acute heart failure (HF) patients and clinical outcomes, a relationship not fully understood.</div></div><div><h3>Methods and results</h3><div>A cohort of 1403 acute HF patients was enrolled with a median follow-up of 20.5 months. Outcomes assessed included cardiovascular (CV) death and/or heart failure hospitalization (CV death & HHP), CV death alone, and all-cause mortality (ACM). Restricted cubic splines analyzed the relationship between admission SUA levels and outcomes. Patients were categorized based on admission and discharge SUA levels into four groups: 1) Normal SUA at both points (N&N), 2) Elevated SUA at admission, normalized at discharge (H&N), 3) Normal SUA at admission, elevated at discharge (N&H), and 4) Elevated SUA at both points (H&H). Associations between SUA categories and outcomes were assessed using COX multivariate regression analysis. Results showed elevated SUA at admission predicted poor outcomes. However, neither N&H nor H&N groups displayed significant increases in CV death & HHP, CV death, or ACM compared to N&N. The H&H group had the highest risks for CV death (adjusted HR 1.79, 95 % CI 1.10–2.93) and ACM (adjusted HR 1.64, 95 % CI 1.08–2.49), with a non-significant trend towards increased risk of CV death & HHP (adjusted HR 1.79, 95 % CI 0.99–2.93).</div></div><div><h3>Conclusion</h3><div>Persistently elevated SUA levels during hospitalization were independently associated with adverse cardiovascular outcomes and ACM in patients with acute HF, whereas fluctuations in SUA levels did not exhibit a similar association.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 6","pages":"Article 104025"},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid profiles and their association with incident carotid atherosclerosis: A community-based prospective study in Taiwan 血脂及其与颈动脉粥样硬化的关系：台湾一项社区前瞻性研究。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-21 DOI: 10.1016/j.numecd.2025.104023

Tzu-Wei Wu , Chao-Liang Chou , Chun-Chieh Liu , Chuen-Fei Chen , Chun-Fang Cheng , Li-Yu Wang

Background and aims

Dyslipidemia, characterized by abnormal blood lipid levels, contributes to atherosclerosis, a condition involving arterial plaque buildup and cardiovascular events. While LDL-C and LDL-to-HDL-C ratios are established atherosclerosis predictors, the role of non-HDL-C is less explored.

Methods and results

A cohort of 1062 participants without carotid plaque at baseline was analyzed over a 4.0-year follow-up. Age-specific incidence rates were calculated, and baseline characteristics of those who developed plaques were compared using logistic regression and area under the ROC curve (AUROC) analysis to evaluate predictive models. Carotid plaques developed in 284 participants (87 males, 197 females). Incidence rates increased with age, reaching 41.2 % in females and 60.0 % in males aged 70–74 years. Participants with plaques were older (58.2 vs. 55.4 years, p < 0.0001), had higher BMI, blood pressure, and lipid markers, and were more likely to be male, hypertensive, or hyperlipidemic. Logistic regression identified age (OR 1.26 per 5 years), BMI (OR 1.23 per 5 kg/m²), LDL-C (OR 1.07 per 10 mg/dL), and LDL-to-HDL-C ratio (OR 1.41) as significant predictors, with HDL-C offering a protective effect. Models incorporating lipid ratios (non-HDL-to-HDL-C or LDL-to-HDL-C) showed similar predictive power (AUROC 0.636).

Conclusion

Carotid plaque progression correlates with age, male sex, elevated BMI, hypertension, and adverse lipid profiles. Lipid ratios and age are consistent predictors, with HDL-C demonstrating protective effects. Comparable AUROC values across models underscore the value of lipid ratios for assessing atherosclerosis risk.

背景和目的：血脂异常，以血脂水平异常为特征，有助于动脉粥样硬化，这是一种涉及动脉斑块形成和心血管事件的疾病。虽然低密度脂蛋白- c和低密度脂蛋白-高密度脂蛋白- c比值是公认的动脉粥样硬化预测指标，但对非高密度脂蛋白- c的作用探索较少。方法和结果：对基线时无颈动脉斑块的1062名参与者进行了为期4年的随访分析。计算年龄特异性发病率，并使用logistic回归和ROC曲线下面积（AUROC）分析比较发生斑块的基线特征，以评估预测模型。284名参与者（87名男性，197名女性）出现颈动脉斑块。发病率随年龄增长而增加，70-74岁女性为41.2%，男性为60.0%。有斑块的参与者年龄较大（58.2岁vs. 55.4岁，p 2）， LDL-C （OR 1.07 / 10mg /dL）和ldl -HDL-C比值（OR 1.41）是显著的预测因子，HDL-C具有保护作用。纳入脂质比率（非hdl -对hdl - c或ldl -对hdl - c）的模型显示出类似的预测能力（AUROC为0.636）。结论：颈动脉斑块进展与年龄、男性、BMI升高、高血压和不良血脂相关。脂质比率和年龄是一致的预测因子，HDL-C显示出保护作用。各模型间的AUROC值比较强调了脂质比率在评估动脉粥样硬化风险方面的价值。

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引用次数: 0

Comparative association of MAFLD/MASLD and Subtypes with Cardiovascular Diseases Outcomes MAFLD/MASLD和亚型与心血管疾病结果的比较关联。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-19 DOI: 10.1016/j.numecd.2025.104024

Huizhen Jin , Zhuoshuai Liang , Xinmeng Hu , Xiaoyang Li , Zhantong Liu , Yichun Qiao , Yi Cheng , Hanxin Yao , Yawen Liu

Background and aims

Metabolic dysfunction-associated steatotic liver disease (MASLD) acts as an alternative for demarcating metabolic dysfunction-associated fatty liver disease (MAFLD). This study aimed to investigate the factors that significantly influence the relationship between MAFLD and MASLD in relation to the incidence of major cardiovascular outcomes.

Methods and results

A total of 340,998 participants in the UK Biobank study were included. Multivariable Cox proportional hazards models were used to estimate the effect of MAFLD and MASLD on the outcomes of cardiovascular diseases (CVDs) (coronary artery disease, stroke, heart failure, and CVD-related death) with hazard ratios (HRs) and 95 % confidence intervals (CIs). A total of 126,077 (36.97 %) participants had MAFLD and 97,418 (28.57 %) had MASLD. Over a median follow-up of 13.5 years (interquartile range 12.6–14.2), there were 41,548 new events of CVDs recorded. MAFLD (HR = 1.52; 95 % CI: 1.49–1.55) and MASLD (HR = 1.42; 95 % CI: 1.39–1.45) were associated with high risks of CVDs. Among the subtypes of MAFLD and steatotic liver disease (SLD), MAFLD diabetes subtype (HR = 2.26; 95 % CI: 2.17–2.35) and alcohol-associated liver disease (ALD) (HR = 1.65; 95 % CI: 1.55–1.76) exhibited the highest risk of CVDs. MAFLD overweight without MD subtype were not associated with CVDs. The effect of MAFLD on the CVD outcomes was consistent regardless of the presence of MASLD.

Conclusion

The metabolic health status and alcohol consumption function as more critical factors than obesity in assessing CVD outcomes in participants with MAFLD or MASLD.

背景和目的：代谢功能障碍相关脂肪性肝病（MASLD）可作为区分代谢功能障碍相关脂肪性肝病（MAFLD）的替代方法。本研究旨在探讨影响MAFLD和MASLD与主要心血管结局发生率关系的因素。方法和结果：英国生物银行研究共纳入340,998名参与者。采用多变量Cox比例风险模型，以风险比（hr）和95%置信区间（ci）估计MAFLD和MASLD对心血管疾病（冠心病、中风、心力衰竭和心血管疾病相关死亡）结局的影响。共有126,077名（36.97%）参与者患有MAFLD， 97,418名（28.57%）参与者患有MASLD。在中位随访13.5年（四分位数间距12.6-14.2）期间，记录了41,548例cvd新病例。mld (hr = 1.52；95% CI: 1.49-1.55)和MASLD (HR = 1.42；95% CI: 1.39-1.45)与心血管疾病的高风险相关。在MAFLD和脂肪变性肝病（SLD）亚型中，MAFLD糖尿病亚型(HR = 2.26；95% CI: 2.17-2.35)和酒精相关性肝病（ALD） (HR = 1.65；95% CI: 1.55-1.76)表现出心血管疾病的最高风险。无MD亚型的MAFLD超重与cvd无相关性。无论是否存在MASLD， mald对CVD结果的影响是一致的。结论：与肥胖相比，代谢健康状况和酒精消耗是评估MAFLD或MASLD患者心血管疾病结局的更关键因素。

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引用次数: 0

Moderate alcohol consumption does not necessarily equate to cardiovascular protection 适度饮酒并不一定等同于心血管保护。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-18 DOI: 10.1016/j.numecd.2025.104022

Stephan Peronard Mayntz , Kasper Emil Rosenbech

引用次数: 0

Strawberries modestly improve cognition and cardiovascular health in older adults. 草莓适度改善老年人的认知和心血管健康。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2025-03-18 DOI: 10.1016/j.numecd.2025.104018

Kristin Delaney, Michelle Tsang, Mark Kern, Vernon Uganiza Rayo, Nathaniel Jason, Mee Young Hong, Changqi Liu, Shirin Hooshmand

Background and aims: Strawberry consumption may aid in improving cognitive function and cardiovascular health given their nutrient composition and antioxidant capacities. We hypothesized that 2 cups of fresh strawberries per day provided as a freeze-dried strawberry powder (26 g/d) may improve cognitive performance and cardiovascular health relative to a control.

Methods and results: Using a randomized, crossover, double-blind, placebo-controlled clinical trial, 35 healthy older adults (17 women, 18 men, age 72 ± 6 years, BMI 26.4 ± 3.9 kg/m²) consumed 26 g of freeze-dried strawberry powder (strawberry) and a control powder (control) daily for 8 weeks each with a 4-week washout period. Strawberry supplementation was expected to improve cardiometabolic health parameters, and cognitive performance measured with the National Institutes of Health Toolbox. Processing speed (p < 0.001) improved during the strawberry phase and episodic memory (p = 0.002) improved during the control phase. For cardiovascular measures, strawberry consumption reduced systolic blood pressure (p = 0.044) and a significant main effect of time for reduced waist circumference (p = 0.043) was detected. Serum triglycerides increased in the control group (p = 0.012) but not after consuming strawberries. Total antioxidant capacity significantly decreased during the control phase (p = 0.032) and significantly increased with strawberry consumption (p = 0.047).

Conclusion: This study demonstrated that 26 g of freeze dried strawberries improve cognitive processing speed, lower systolic blood pressure, and increase antioxidant capacity, potentially promoting cognitive function and improving cardiovascular risk factors in cognitively healthy individuals.

Clinical trial registry: NCT04786665.

背景和目的：考虑到草莓的营养成分和抗氧化能力，食用草莓可能有助于改善认知功能和心血管健康。我们假设，与对照组相比，每天2杯新鲜草莓作为冻干草莓粉（26克/天）可能改善认知能力和心血管健康。方法与结果：采用随机、交叉、双盲、安慰剂对照的临床试验，35名健康老年人（女性17名，男性18名，年龄72±6岁，BMI 26.4±3.9 kg/m2），每天食用26g冻干草莓粉（strawberry）和对照粉（control），各8周，并有4周的洗期。草莓补充剂有望改善心脏代谢健康参数，并通过美国国立卫生研究院工具箱测量认知能力。结论：本研究表明，26g冻干草莓可提高认知处理速度，降低收缩压，提高抗氧化能力，可能促进认知功能并改善认知健康个体的心血管危险因素。临床试验注册：NCT04786665。

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引用次数: 0