The impact of platelet transfusion on prognosis in adult burn patients with thrombocytopenia: A propensity score matching analysis

IF 3.2 3区医学 Q2 CRITICAL CARE MEDICINE Burns Pub Date : 2024-08-22 DOI:10.1016/j.burns.2024.08.003

Kun Xiao , Wei Xiong , Qiang Liu , Hongao Deng , Zhanglin Zhang , Kuai Yu , Piaoping Hu , Yunzhi Dong , Aiping Le

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Abstract

Background and objectives

Thrombocytopenia is common among burn patients. Platelet transfusion is frequently administered to increase platelet counts. However, it is not clear whether platelets affect the outcome after transfusion among adult burn patients with thrombocytopenia. Our aim is to explore whether platelet transfusion affects the prognosis of adult burn patients with thrombocytopenia.

Methods

We undertook a retrospective analysis of 368 adult burn victims with thrombocytopenia from the Department of Burn at the First Affiliated Hospital of Nanchang University, China, from January 2014 to July 2021. Propensity score matching (PSM) was utilized to reduce selection bias and confounding factors. After PSM, the platelet transfusion group and the no-platelet transfusion group each had 46 patients. Our primary outcome was 30-day all-cause mortality.

Results

Logistic multivariate regression analysis showed that third-degree burn area [β = -0.040, odds ratio (OR) = 1.052, 95 % confidence interval (CI) = 1.015–1.091] and platelet transfusion (OR =2.227, 95 % CI = 0.473–10.483) were independent risk factors (P < 0.05). KaplanMeier analysis showed that the 30-day mortality of patients in the platelet transfusion group and no-platelet transfusion group were 47.8 % and 19.6 %, respectively (P < 0.05)

Conclusion

Platelet transfusion was an independent risk factor for 30-day mortality in adult burn patients with thrombocytopenia.

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输注血小板对患有血小板减少症的成年烧伤患者预后的影响：倾向得分匹配分析

背景和目的：血小板减少症在烧伤患者中很常见。输注血小板可增加血小板计数。然而，血小板是否会影响患有血小板减少症的成年烧伤患者输血后的预后尚不清楚。我们的目的是探讨输注血小板是否会影响血小板减少症成人烧伤患者的预后：我们对南昌大学第一附属医院烧伤科 2014 年 1 月至 2021 年 7 月的 368 名血小板减少的成年烧伤患者进行了回顾性分析。采用倾向评分匹配法（PSM）减少选择偏差和混杂因素。经过倾向得分匹配后，输注血小板组和不输注血小板组各有46名患者。我们的主要结果是 30 天全因死亡率：逻辑多变量回归分析显示，三度烧伤面积[β = -0.040，几率比（OR）= 1.052，95 % 置信区间（CI）= 1.015-1.091]和血小板输注（OR =2.227，95 % CI = 0.473-10.483）是独立的风险因素（P＜0.05）。

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.