Burns最新文献

{"title":"Preparation and assessment of polylactic acid-curcumin nanofibrous wound dressing containing silver nanoparticles for burn wound treatment","authors":"Mehri Moayedi ,&nbsp;Tahmineh Ahmadi ,&nbsp;Vahid Nekouie ,&nbsp;Majid Taghian Dehaghani ,&nbsp;Shahrokh Shojaei ,&nbsp;Soheila Zamalui Benisi ,&nbsp;Hamid Reza Bakhsheshi-Rad","doi":"10.1016/j.burns.2025.107442","DOIUrl":"10.1016/j.burns.2025.107442","url":null,"abstract":"<div><div>This study aims to produce and evaluate nanofibrous wound dressings through the electrospinning method, utilizing polylactic acid (PLA), curcumin (Cur), and silver nanoparticles (AgNPs). For this purpose, five types of wound dressings with PLA, PLA+Cur, PLA+Cur+ 1 %AgNPs, PLA+Cur+ 2 %AgNPs and PLA+Cur+ 3 %AgNPs were produced using the electrospinning method. Analysis of the Fourier transform infrared spectroscopy and scanning electron microscopic observations indicated successful fabrication, with nanometer diameters achieved in all electrospun samples. Examination of water absorption of wound dressings revealed that over 40 h the electrospun samples had variable water absorption between 0 % and 0.25 %. The results of the curcumin release test over one week showed that the nanofibers with PLA+Cur+ 2 %AgNPs exhibited the lowest release rate, while those with PLA+Cur+ 3 %AgNPs showed the highest release. Assessment of mechanical properties revealed that the tensile strength of the nanofibers increased by adding curcumin to polylactic acid, while the addition of a high content of AgNPs led to a decrease in tensile strength. Also, the PLA+Cur dressing demonstrated 84.06 % and the PLA+Cur+ 3 %AgNPs dressing exhibited 99.12 % antibacterial properties. The cell culture test demonstrated that the incorporation of curcumin and AgNPs increasedboth the growth and proliferation, as well as the adhesion on the nanofibrous wound dressing. Thus, the PLA+Cur+ 1 %AgNPs nanofibrous scaffold, as a multipurpose dressing, presented considerable promise for wound healing and burn treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107442"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Burn rotations in general surgery residency","authors":"Barret J. Halgas,&nbsp;Jonathan B. Lundy,&nbsp;Leopoldo C. Cancio","doi":"10.1016/j.burns.2025.107430","DOIUrl":"10.1016/j.burns.2025.107430","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107430"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial","authors":"María Dolores Pérez-Del-Caz ,&nbsp;Nieves Vanaclocha ,&nbsp;Pilar Sepúlveda Sanchis ,&nbsp;María Blanes ,&nbsp;Bruno Marco ,&nbsp;Rafael Botella Estrada ,&nbsp;Eduardo García-Granero Ximénez ,&nbsp;Luís Sabater Ortí ,&nbsp;Aranzazu Pérez-Plaza","doi":"10.1016/j.burns.2025.107427","DOIUrl":"10.1016/j.burns.2025.107427","url":null,"abstract":"<div><h3>Introduction</h3><div>Split-thickness skin autografts are the gold standard for surgical treatment of burns. In preclinical studies, the use of SKINHEALTEX PLGA, an electrospun poly(lactic-co-glycolide) acid (PLGA) bioveil, placed between autografts and their bed has shown potential to stimulate dermal regeneration, increase graft take and improve scar quality. These properties have not yet been evaluated in human clinical trials.</div></div><div><h3>Objective</h3><div>The primary goal of this study was to evaluate tolerability and safety of SKINHEALTEX PLGA on human tissues, specifically, split-thickness skin autografts and wound beds of debrided burns.</div></div><div><h3>Materials and methods</h3><div>A double-blind randomised controlled clinical trial was conducted with adult patients with deep burns requiring surgical treatment, for 4 years (November 2018 to September 2022). Each patient acted as their own control, and they were followed for 12 months. In the control area a skin autograft was applied, while in the treatment area SKINHEALTEX PLGA was interposed between the autograft and the bed. The outcome variables were incidence of adverse events, the percentage of graft take (evaluated clinically), and Vancouver Scar Scale and Patient and Observer Scar Assesment Scale scores.</div></div><div><h3>Results</h3><div>The bioveil was well tolerated in the 26 patients that were recruited. No adverse events related to SKINHEALTEX PLGA were observed. No statistically significant differences were observed in split-thickness skin autograft take and subsequent scar quality between the control group (split-thickness skin autografts alone) and the autograft and SKINHEALTEX PLGA group.</div></div><div><h3>Conclusion</h3><div>This is the first clinical trial investigating the application of an electrospun biomaterial in the treatment of burns using skin autografts. SKINHEALTEX PLGA is a biocompatible and safe product that can be applied as an interface between autografts and the debrided bed of a burn without reducing graft take. Further research is needed to assess the value of SKINHEALTEX PLGA for burn wounds and its potential as an administration route of molecules than enhance dermal regeneration in burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107427"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Cement burns among manual labourers in the UK: An urgent call for improved safety measures and education","authors":"Kevin Serror ,&nbsp;Alexandre Saiporn ,&nbsp;Lauren Ferrero ,&nbsp;Pr David Boccara ,&nbsp;Pr Marc Chaouat","doi":"10.1016/j.burns.2025.107429","DOIUrl":"10.1016/j.burns.2025.107429","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107429"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the dressing matter in pediatric partial-thickness burns: a systematic review and meta-analysis","authors":"Milly S van de Warenburg ,&nbsp;Bente Teeuwen ,&nbsp;Stefan Hummelink ,&nbsp;Dietmar JO Ulrich ,&nbsp;Mariëlle LAW Vehmeijer-Heeman","doi":"10.1016/j.burns.2025.107428","DOIUrl":"10.1016/j.burns.2025.107428","url":null,"abstract":"<div><div>Superficial partial thickness burns typically receive nonoperative treatment, whereas deep partial thickness burns, which are prone to hypertrophic scarring, are usually managed through debridement followed by autologous split-thickness skin grafting. Various therapies have been developed to prevent wound infection and to enhance wound healing in pediatric partial-thickness burns. However, the choice of dressing by the surgeon can be influenced by various factors. It is worth noting that there is no standardized approach across all burn centers, leading to variations in care practices. To optimize pediatric patient care, a systematic review was conducted following PRISMA guidelines to review existing treatment options for partial thickness burns in children. Outcomes of interest were wound healing time, dressing changes, length of hospital stay, wound infections, need for grafting despite treatment, and hypertrophic scarring. A total of 68 studies with 8199 patients were included. The mean age of the included patients was 3.1 years, and the mean total body surface area of the burns was 15.6 %. Treatment groups included topical agents, bandages, skin analogues, or unclassified. Considering all treatment outcomes evaluated in this systematic review of the literature, non-silver dressings and skin analogues may have some benefit over topical agents in terms of wound healing time, length of hospital stay, hypertrophic scarring, pain management, and cost saving. Dressing changes, wound infections, and need for grafting did not significantly change between various treatments.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107428"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of silk dressings in the treatment of skin injuries: A systematic review","authors":"Leen Vermoesen ,&nbsp;Ignace De Decker ,&nbsp;Jozef Verbelen ,&nbsp;Henk Hoeksema ,&nbsp;Kimberly De Mey ,&nbsp;Petra De Coninck ,&nbsp;Julie van Durme ,&nbsp;Nathalie Roche ,&nbsp;Stan Monstrey ,&nbsp;Karel E.Y. Claes","doi":"10.1016/j.burns.2025.107426","DOIUrl":"10.1016/j.burns.2025.107426","url":null,"abstract":"<div><h3>Background</h3><div>Skin injuries like superficial burns and skin graft donor sites are currently managed using various dressings. Frequent challenges include discomfort and trauma during dressing changes, suboptimal healing and significant scarring. Silk dressings show promise by reducing the need for frequent changes, allowing wound evaluation due to its transparency, exerting antibacterial properties, and minimizing scarring. However, silk is not yet widely adopted in clinical settings.</div></div><div><h3>Methods</h3><div>A systematic review was conducted. A search through 3 databases (PubMed, Embase, Cochrane Library) according to the PRISMA guidelines was performed. Only RCTs, cohort studies, case-control studies and case series were included. Appropriate quality tests were performed.</div></div><div><h3>Results</h3><div>1373 search results were identified. After deduplication, 979 were screened by title and abstract, of which 20 full-text articles remained and ultimately, 9 articles were included. Parameters examined were: healing duration, pain, subjective and objective skin measurements, adverse events, infection rates, transparency and price.</div></div><div><h3>Conclusion</h3><div>Silk dressings demonstrate comparable efficacy to existing dressings concerning transparency, healing time, pain, erythema, pigmentation, water loss normalization, firmness, visco-elasticity recovery, microcirculation, adverse events and infection rates. They are an economically interesting alternative for managing superficial partial-thickness skin burns and skin graft donor sites. Nonetheless, larger high-quality studies are needed to confirm these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107426"},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Th1/Th2 cytokine levels: A potential diagnostic tool for patients with necrotizing fasciitis” [Burns 49 (2023) 200–208]","authors":"Xiang-Wei Ling ,&nbsp;Ting-Ting Zhang ,&nbsp;Meng-Meng Ling ,&nbsp;Wei-Hao Chen ,&nbsp;Chun-Hui Huang ,&nbsp;Guo-Liang Shen","doi":"10.1016/j.burns.2024.107371","DOIUrl":"10.1016/j.burns.2024.107371","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107371"},"PeriodicalIF":3.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the efficacy and safety of calcium gluconate soaking as a treatment modality for hydrofluoric acid burns","authors":"Chi-Syuan Pan ,&nbsp;Chi-Chan Lee ,&nbsp;Jiun-Hao Yu ,&nbsp;Han-Wei Mu ,&nbsp;Dong-Zong Hung ,&nbsp;Chun-Hung Chen","doi":"10.1016/j.burns.2025.107422","DOIUrl":"10.1016/j.burns.2025.107422","url":null,"abstract":"<div><h3>Introduction</h3><div>Hydrofluoric acid is extremely toxic and can corrode tissues while reacting with calcium and magnesium, leading to severe tissue damage. The antidote, calcium gluconate, is effective for treating mild to moderate burns. However, our hospital lacks registered calcium gluconate gel, making treatment challenging. We investigated alternative soaking methods due to scant literature on this approach.</div></div><div><h3>Methods</h3><div>This retrospective case series study reviews hydrofluoric acid burn cases at China Medical University Hospital from 2004 and 2020, focusing on the effectiveness of calcium gluconate soaking. Among 29 patients treated for hydrofluoric acid burns in our emergency department, treatments included nail removal and debridement, but all received calcium gluconate soaks without requiring calcium injections.</div></div><div><h3>Results</h3><div>In our emergency department, 29 patients with hydrofluoric acid burns were treated; 8 required hospitalization and one was admitted to the intensive care unit. Burns varied widely in acid concentration (0.03 %-49 %) and size (1.60 ± 2.93 % body surface area). Treatments included nail removal for one patient and debridement for four. All patients underwent calcium gluconate soaking; none received intra-arterial or subcutaneous injections. There were no fatalities or significant electrolyte imbalances.</div></div><div><h3>Discussion</h3><div>Calcium gluconate soaking is effective for treating mild HF burns in the absence of gel. However, the lack of a control group limits the ability to compare its efficacy to other treatments.</div></div><div><h3>Conclusion</h3><div>Calcium gluconate soaking may serve as a practical alternative for treating minor HF burns.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107422"},"PeriodicalIF":3.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can seeing the photos of patients' faces before burns affect nurses' quality of care?","authors":"Mohammad Ali Majdoddin,&nbsp;Masoud Yavari,&nbsp;Samad Karkhah,&nbsp;Mostafa Saeedinia","doi":"10.1016/j.burns.2025.107423","DOIUrl":"10.1016/j.burns.2025.107423","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107423"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of immune-related biomarkers and polarization types of macrophages in keloid based on bulk RNA-seq and single-cell RNA-seq analysis","authors":"Yuzhu Zhang ,&nbsp;Chenglong Fang ,&nbsp;Lizhong Zhang ,&nbsp;Fengyu Ma ,&nbsp;Meihong Sun ,&nbsp;Ning Zhang ,&nbsp;Nan Bai ,&nbsp;Jun Wu","doi":"10.1016/j.burns.2025.107413","DOIUrl":"10.1016/j.burns.2025.107413","url":null,"abstract":"<div><h3>Introduction</h3><div>Keloids are a common complication that occurs after injury. The pathogenesis of this disease remains unknown. Therefore, identifying immune-related biomarkers and macrophage polarization types in keloids can provide new insights into their treatment.</div></div><div><h3>Methods</h3><div>In this study, keloid-related bulk RNA-seq data (GSE83286, GSE212954, GSE92566, and GSE90051) were obtained from the Gene Expression Omnibus (GEO) database. The datasets GSE83286, GSE212964, and GSE92566 were combined to form a training set, while GSE90051 was utilized as an external validation set. Differentially expressed genes (DEGs) were detected by comparing keloid and normal samples within the training set. Differentially expressed immune-related genes (DIRGs) were then determined by intersecting the DEGs with immune-related genes (IRGs). Based on the protein-protein interaction (PPI) network, the top 40 DIRGs were selected for further analyses. Weighted Gene Co-expression Network Analysis (WGCNA), in conjunction with three machine learning techniques - least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and random forest (RF) - employed to identify biomarkers. Subsequently, a nomogram model was constructed and validated. Single-cell RNA (scRNA) analysis was used to examine the expression of biomarkers at the cell-type level. Furthermore, since keloid is a chronic inflammatory disease and the abnormal polarization of macrophages is essential for the occurrence of this kind of disease, in this study we also endeavor to elucidate the state of macrophage polarization dysregulation within keloid, with the anticipation of generating novel concepts for the treatment of keloid. Finally, western blot (WB) and immunofluorescence (IF) analyses were carried out to confirm the expression levels of the biomarkers.</div></div><div><h3>Results</h3><div>A total of 740 DEGs were identified in the training set, comprising 331 up-regulated genes and 409 down-regulated genes. After intersecting with the IRGs, 73 DIRGs were obtained. Subsequently, the top 40 DIRGs were chosen for further analysis. Eventually, two biomarkers, namely BMP1 and IL1R1, were identified through WGCNA and the three machine learning methods. Their expression levels were then verified by single-cell analysis, WB, and IF analysis. Additionally, it was found that the number of M2 macrophages significantly increased, while the number of M1 macrophages decreased in keloids compared to normal samples.</div></div><div><h3>Conclusion</h3><div>BMP1 and IL1R1 might function as novel biomarkers and potential therapeutic targets for keloid treatment. Moreover, upregulating M1 macrophages and downregulating M2 macrophages could represent a promising approach for the treatment of keloids.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107413"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}