Burns最新文献

{"title":"Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial","authors":"María Dolores Pérez-Del-Caz ,&nbsp;Nieves Vanaclocha ,&nbsp;Pilar Sepúlveda Sanchis ,&nbsp;María Blanes ,&nbsp;Bruno Marco ,&nbsp;Rafael Botella Estrada ,&nbsp;Eduardo García-Granero Ximénez ,&nbsp;Luís Sabater Ortí ,&nbsp;Aranzazu Pérez-Plaza","doi":"10.1016/j.burns.2025.107427","DOIUrl":"10.1016/j.burns.2025.107427","url":null,"abstract":"<div><h3>Introduction</h3><div>Split-thickness skin autografts are the gold standard for surgical treatment of burns. In preclinical studies, the use of SKINHEALTEX PLGA, an electrospun poly(lactic-co-glycolide) acid (PLGA) bioveil, placed between autografts and their bed has shown potential to stimulate dermal regeneration, increase graft take and improve scar quality. These properties have not yet been evaluated in human clinical trials.</div></div><div><h3>Objective</h3><div>The primary goal of this study was to evaluate tolerability and safety of SKINHEALTEX PLGA on human tissues, specifically, split-thickness skin autografts and wound beds of debrided burns.</div></div><div><h3>Materials and methods</h3><div>A double-blind randomised controlled clinical trial was conducted with adult patients with deep burns requiring surgical treatment, for 4 years (November 2018 to September 2022). Each patient acted as their own control, and they were followed for 12 months. In the control area a skin autograft was applied, while in the treatment area SKINHEALTEX PLGA was interposed between the autograft and the bed. The outcome variables were incidence of adverse events, the percentage of graft take (evaluated clinically), and Vancouver Scar Scale and Patient and Observer Scar Assesment Scale scores.</div></div><div><h3>Results</h3><div>The bioveil was well tolerated in the 26 patients that were recruited. No adverse events related to SKINHEALTEX PLGA were observed. No statistically significant differences were observed in split-thickness skin autograft take and subsequent scar quality between the control group (split-thickness skin autografts alone) and the autograft and SKINHEALTEX PLGA group.</div></div><div><h3>Conclusion</h3><div>This is the first clinical trial investigating the application of an electrospun biomaterial in the treatment of burns using skin autografts. SKINHEALTEX PLGA is a biocompatible and safe product that can be applied as an interface between autografts and the debrided bed of a burn without reducing graft take. Further research is needed to assess the value of SKINHEALTEX PLGA for burn wounds and its potential as an administration route of molecules than enhance dermal regeneration in burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107427"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Cement burns among manual labourers in the UK: An urgent call for improved safety measures and education","authors":"Kevin Serror ,&nbsp;Alexandre Saiporn ,&nbsp;Lauren Ferrero ,&nbsp;Pr David Boccara ,&nbsp;Pr Marc Chaouat","doi":"10.1016/j.burns.2025.107429","DOIUrl":"10.1016/j.burns.2025.107429","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107429"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of silk dressings in the treatment of skin injuries: A systematic review","authors":"Leen Vermoesen ,&nbsp;Ignace De Decker ,&nbsp;Jozef Verbelen ,&nbsp;Henk Hoeksema ,&nbsp;Kimberly De Mey ,&nbsp;Petra De Coninck ,&nbsp;Julie van Durme ,&nbsp;Nathalie Roche ,&nbsp;Stan Monstrey ,&nbsp;Karel E.Y. Claes","doi":"10.1016/j.burns.2025.107426","DOIUrl":"10.1016/j.burns.2025.107426","url":null,"abstract":"<div><h3>Background</h3><div>Skin injuries like superficial burns and skin graft donor sites are currently managed using various dressings. Frequent challenges include discomfort and trauma during dressing changes, suboptimal healing and significant scarring. Silk dressings show promise by reducing the need for frequent changes, allowing wound evaluation due to its transparency, exerting antibacterial properties, and minimizing scarring. However, silk is not yet widely adopted in clinical settings.</div></div><div><h3>Methods</h3><div>A systematic review was conducted. A search through 3 databases (PubMed, Embase, Cochrane Library) according to the PRISMA guidelines was performed. Only RCTs, cohort studies, case-control studies and case series were included. Appropriate quality tests were performed.</div></div><div><h3>Results</h3><div>1373 search results were identified. After deduplication, 979 were screened by title and abstract, of which 20 full-text articles remained and ultimately, 9 articles were included. Parameters examined were: healing duration, pain, subjective and objective skin measurements, adverse events, infection rates, transparency and price.</div></div><div><h3>Conclusion</h3><div>Silk dressings demonstrate comparable efficacy to existing dressings concerning transparency, healing time, pain, erythema, pigmentation, water loss normalization, firmness, visco-elasticity recovery, microcirculation, adverse events and infection rates. They are an economically interesting alternative for managing superficial partial-thickness skin burns and skin graft donor sites. Nonetheless, larger high-quality studies are needed to confirm these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107426"},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Th1/Th2 cytokine levels: A potential diagnostic tool for patients with necrotizing fasciitis” [Burns 49 (2023) 200–208]","authors":"Xiang-Wei Ling ,&nbsp;Ting-Ting Zhang ,&nbsp;Meng-Meng Ling ,&nbsp;Wei-Hao Chen ,&nbsp;Chun-Hui Huang ,&nbsp;Guo-Liang Shen","doi":"10.1016/j.burns.2024.107371","DOIUrl":"10.1016/j.burns.2024.107371","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107371"},"PeriodicalIF":3.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can seeing the photos of patients' faces before burns affect nurses' quality of care?","authors":"Mohammad Ali Majdoddin,&nbsp;Masoud Yavari,&nbsp;Samad Karkhah,&nbsp;Mostafa Saeedinia","doi":"10.1016/j.burns.2025.107423","DOIUrl":"10.1016/j.burns.2025.107423","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107423"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of immune-related biomarkers and polarization types of macrophages in keloid based on bulk RNA-seq and single-cell RNA-seq analysis","authors":"Yuzhu Zhang ,&nbsp;Chenglong Fang ,&nbsp;Lizhong Zhang ,&nbsp;Fengyu Ma ,&nbsp;Meihong Sun ,&nbsp;Ning Zhang ,&nbsp;Nan Bai ,&nbsp;Jun Wu","doi":"10.1016/j.burns.2025.107413","DOIUrl":"10.1016/j.burns.2025.107413","url":null,"abstract":"<div><h3>Introduction</h3><div>Keloids are a common complication that occurs after injury. The pathogenesis of this disease remains unknown. Therefore, identifying immune-related biomarkers and macrophage polarization types in keloids can provide new insights into their treatment.</div></div><div><h3>Methods</h3><div>In this study, keloid-related bulk RNA-seq data (GSE83286, GSE212954, GSE92566, and GSE90051) were obtained from the Gene Expression Omnibus (GEO) database. The datasets GSE83286, GSE212964, and GSE92566 were combined to form a training set, while GSE90051 was utilized as an external validation set. Differentially expressed genes (DEGs) were detected by comparing keloid and normal samples within the training set. Differentially expressed immune-related genes (DIRGs) were then determined by intersecting the DEGs with immune-related genes (IRGs). Based on the protein-protein interaction (PPI) network, the top 40 DIRGs were selected for further analyses. Weighted Gene Co-expression Network Analysis (WGCNA), in conjunction with three machine learning techniques - least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and random forest (RF) - employed to identify biomarkers. Subsequently, a nomogram model was constructed and validated. Single-cell RNA (scRNA) analysis was used to examine the expression of biomarkers at the cell-type level. Furthermore, since keloid is a chronic inflammatory disease and the abnormal polarization of macrophages is essential for the occurrence of this kind of disease, in this study we also endeavor to elucidate the state of macrophage polarization dysregulation within keloid, with the anticipation of generating novel concepts for the treatment of keloid. Finally, western blot (WB) and immunofluorescence (IF) analyses were carried out to confirm the expression levels of the biomarkers.</div></div><div><h3>Results</h3><div>A total of 740 DEGs were identified in the training set, comprising 331 up-regulated genes and 409 down-regulated genes. After intersecting with the IRGs, 73 DIRGs were obtained. Subsequently, the top 40 DIRGs were chosen for further analysis. Eventually, two biomarkers, namely BMP1 and IL1R1, were identified through WGCNA and the three machine learning methods. Their expression levels were then verified by single-cell analysis, WB, and IF analysis. Additionally, it was found that the number of M2 macrophages significantly increased, while the number of M1 macrophages decreased in keloids compared to normal samples.</div></div><div><h3>Conclusion</h3><div>BMP1 and IL1R1 might function as novel biomarkers and potential therapeutic targets for keloid treatment. Moreover, upregulating M1 macrophages and downregulating M2 macrophages could represent a promising approach for the treatment of keloids.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107413"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pre-existing cancer diagnoses on burn injury survival and morbidity","authors":"Phillip Keys ,&nbsp;Kassandra Corona ,&nbsp;Sheldon McCown ,&nbsp;Lyndon Huang ,&nbsp;Elvia Villarreal ,&nbsp;Jasmine Chaij ,&nbsp;Giovanna De La Tejera ,&nbsp;Douglas S. Tyler ,&nbsp;George Golovko ,&nbsp;Amina El Ayadi ,&nbsp;Juquan Song ,&nbsp;Steven E. Wolf","doi":"10.1016/j.burns.2025.107414","DOIUrl":"10.1016/j.burns.2025.107414","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe burns place patients in a compromised state, especially those with pre-existing chronic diseases such as malignancy. Due to improvements in detection and treatment, cancer mortality has declined significantly, leaving a growing population of cancer survivors. Therefore, we wondered whether pre-existing cancer diagnoses influence patient outcomes following burn injury.</div></div><div><h3>Methods</h3><div>46,275 patients with a neoplasm diagnosis prior to experiencing a burn injury were identified using the TriNetX research network. Two control groups were organized: 1) cancer patients without burns and 2) burn patients with no history of cancer. The test group included patients with a pre-existing cancer diagnosis who received a subsequent burn injury. Outcomes included death, sepsis, nutritional deficiency, eating disorder, immunodeficiency, and depression. Odds ratios were calculated with 95 % confidence intervals.</div></div><div><h3>Results</h3><div>Of the nearly 10 million cancer patients, 0.45 % experienced a burn injury after diagnosis. Compared to propensity-matched burned patients without cancer, burned patients with a previous cancer diagnosis had increased odds of developing sepsis (2.013, 1.895–2.138), nutritional deficiency (1.874, 1.58–2.221), immunodeficiency (5.584, 4.85–7.06), eating disorder (2.384, 1.947–2.918), and depression (1.772, 1.695–1.853). The odds ratios of sepsis (1.718, 1.612–1.83), nutritional deficiency (1.963, 1.593–2.418), immunodeficiency (1.265, 1.098–1.459), eating disorder (2.569, 2.077–3.177), and depression (1.538, 1.468–1.611) were increased when compared to cancer patients without burn injury. Burned patients with a previous neoplasm of hematologic origin fared worse in the odds of developing the mentioned outcomes compared to those with solid neoplasms. Lastly, burned patients with any previous neoplasm who later received chemotherapy and/or radiation suffered worse outcomes than those who never received such treatment.</div></div><div><h3>Conclusion</h3><div>Patients who developed neoplasms before receiving a burn injury demonstrated considerable increases in odds of poor outcomes. Increased odds of developing poor outcomes were greater in those with hematologic neoplasms and those who received chemotherapy or radiation treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107414"},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study on the evaluation of rehabilitation outcomes in patients with deep hand burns using hand strength monitoring","authors":"Yaliga Ba ,&nbsp;Fang Li ,&nbsp;Yongfei Wu ,&nbsp;Te Ba ,&nbsp;Lingfeng Wang ,&nbsp;Shengjun Cao ,&nbsp;Quan Li","doi":"10.1016/j.burns.2025.107415","DOIUrl":"10.1016/j.burns.2025.107415","url":null,"abstract":"<div><h3>Background</h3><div>To provide reference for hand function assessment and treatment effectiveness by measuring changes in muscle strength before and after rehabilitation in patients with deep hand burns.</div></div><div><h3>Methods</h3><div>Clinical data from 112 patients with deep right hand burns treated at the Third Affiliated Hospital of Inner Mongolia Medical University were collected. Passive Functional Training: hand training was conducted using the continuous passive motion system, once daily for 40 minutes each session. The therapist performed resistance exercises, stretching training, and other motion therapies on the fingers. Specific pressure therapy was applied by the therapist based on the location and shape of the scars. Grip strength and finger to finger strength data of hand burn patients were measured before and after treatment on days 14, 21, 28, 35, 42, 60, 90, and 120 after wound healing. Scores from the Fugl-Meyer hand motor section, Michigan Hand Outcomes Questionnaire (MHQ), Vancouver Scar Scale (VSS), and Visual Analog Scale (VAS) for Pain were recorded before treatment. A two-way ANOVA was employed to evaluate the effects of time and group on rehabilitation outcomes. Pearson and Spearman correlation analysis were employed to explore correlations among variables.</div></div><div><h3>Results</h3><div>The two-way ANOVA analysis demonstrated significant effects of time, treatment, and their interaction (all <em>P</em> &lt; 0.001). Statistically significant differences in resultant force were observed between pre- and post-treatment at days 21, 28, 35, 42 and 60 ( all <em>P</em>＜0.001). The correlation coefficients between pre-treatment resultant force and Fugl-Meyer and MHQ scores were 0.848 and 0.852, respectively. The correlation coefficient between resultant force and grip strength was 0.899.</div></div><div><h3>Conclusions</h3><div>Measurement of hand muscle strength after wound healing could serve as a critical index for assessing hand function recovery status.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107415"},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REsource Support To Optimize REcovery (RESTORE) scoping review: Evaluating aftercare resources for burn survivors","authors":"Mariana Velásquez-Cano ,&nbsp;Renee Noordzij ,&nbsp;Camille Carnevale ,&nbsp;Lauren J. Shepler ,&nbsp;Diana Tenney-Laperriere ,&nbsp;Lewis E. Kazis ,&nbsp;Colleen M. Ryan ,&nbsp;Mary D. Slavin ,&nbsp;Jeffrey C. Schneider","doi":"10.1016/j.burns.2024.107350","DOIUrl":"10.1016/j.burns.2024.107350","url":null,"abstract":"<div><h3>Background</h3><div>Burn survivors report limited resources as they transition to their communities after initial hospitalization. The aim of this project is to review literature that identifies resources provided to burn survivors and their supporters after discharge to their communities.</div></div><div><h3>Methods</h3><div>The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to examine the following literature databases: PubMed, EMBASE, Web of Science, PsycInfo, and CINAHL. The World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set for burn injury provided a framework to categorize resource content.</div></div><div><h3>Results</h3><div>Of the 637 articles screened, 27 met inclusion criteria. Data extraction identified resources categorized into the following ICF components: Body Functions, Activities and Participation, and Environmental Factors.</div></div><div><h3>Conclusion</h3><div>This review uses a conceptual framework to provide an overview of current published resources to support burn survivors following hospitalization. The identified resources addressed content such as health professionals, programs, psychological functioning after burn injury, scar management, and virtual resources. Based on the ICF framework, some gaps in resource content were noted such as pain, thermoregulation, interpersonal relationships, and self-care. Findings reveal relative strengths and gaps in resources, which can be used to better support burn survivors following hospitalization.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107350"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Editorial board page” [Burns JBUR 50/8 (2024) Page i]","authors":"","doi":"10.1016/j.burns.2024.107338","DOIUrl":"10.1016/j.burns.2024.107338","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107338"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}