Antifungal Susceptibility Data and Epidemiological Distribution of Candida spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES Antibiotics-Basel Pub Date : 2024-09-24 DOI:10.3390/antibiotics13100914

Maddalena Calvo, Guido Scalia, Laura Trovato

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Abstract

Background: Invasive fungal infections represent a concerning healthcare issue, with Candida spp. reported as the main aetiological agent. Candida spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes as a contributing feature. Despite the global prevalence of C. albicans, non-albicans species emerged as significant in the last decades.

Methods: The present manuscript reports a five-year evaluation on Candida spp. bloodstream isolates and their antifungal susceptibility profiles, aiming to enrich the literature and epidemiological data.

Results: According to the gathered data, antifungal-resistance cases remained uncommon. However, the study revealed rare resistance phenotypes such as a single case of pan-echinocandin resistance C. albicans.

Conclusions: Finally, a comprehensive review of Candida spp. antifungal resistance integrates the data, emphasizing the extreme species-specific variability and the consequent importance of always providing species identification.

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卡塔尼亚大学波利尼科医院的抗真菌敏感性数据和念珠菌属的流行病学分布：卡塔尼亚 Policlinico 大学医院的五年体外评估和全面文献综述。

背景：侵袭性真菌感染是一个令人担忧的医疗保健问题，据报道念珠菌属是主要的致病菌。白色念珠菌属血流感染的死亡率很高，这表明抗真菌药物耐药性的增加是一个原因。尽管白念珠菌在全球流行，但在过去几十年中，非白念珠菌物种也成为重要的致病菌：本手稿报告了对白色念珠菌属血液分离株及其抗真菌药敏谱进行的五年评估，旨在丰富文献和流行病学数据：结果：根据收集到的数据，抗真菌耐药病例仍不常见。然而，研究发现了罕见的耐药表型，如一例白念珠菌对泛-棘白菌素耐药：最后，对念珠菌属抗真菌耐药性的全面回顾整合了数据，强调了物种特异性的极端变异性以及始终提供物种鉴定的重要性。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.