A Systematic Review and Comprehensive Analysis of mcr Gene Prevalence in Bacterial Isolates in Arab Countries.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES Antibiotics-Basel Pub Date : 2024-10-11 DOI:10.3390/antibiotics13100958

Mouayad Zuheir Bakleh, Muhammad Kohailan, Muhammad Marwan, Abdallah Alhaj Sulaiman

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Abstract

Background: The resurgence of colistin has become critical in combating multidrug-resistant Gram-negative bacteria. However, the emergence of mobilized colistin resistance (mcr) genes presents a crucial global challenge, particularly in the Arab world, which includes regions with unique conditions and ongoing conflicts in some parts.

Methods: To address this issue, a systematic review was conducted using multiple databases, including Cochrane, PubMed, Scopus, Web of Science, and Arab World Research Source.

Results: A total of 153 studies were included, revealing substantial heterogeneity in the prevalence of mcr genes across 15 Arab countries, with notable findings indicating that Egypt and Lebanon reported the highest number of cases. The analysis indicated that the most prevalent sequence types were ST10, ST101, and ST1011, all of which are Escherichia coli strains linked to significant levels of colistin resistance and multiple antimicrobial resistance profiles.

Conclusions: By analyzing the diverse findings from different Arab countries, this review lays a critical foundation for future research and highlights the necessity for enhanced surveillance and targeted interventions to address the looming threat of colistin resistance in the region.

Systematic review registration: PROSPERO CRD42024584379.

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阿拉伯国家细菌分离物中 mcr 基因流行情况的系统回顾和综合分析。

背景：可乐定的重新出现已成为抗击耐多药革兰氏阴性菌的关键。然而，可乐定耐药性（mcr）基因的出现带来了严峻的全球性挑战，尤其是在阿拉伯世界，其中包括一些条件独特的地区，以及某些地区正在发生的冲突：为解决这一问题，我们使用多个数据库进行了系统性综述，包括 Cochrane、PubMed、Scopus、Web of Science 和 Arab World Research Source：结果：共纳入 153 项研究，发现 15 个阿拉伯国家的 mcr 基因流行率存在很大的异质性，其中埃及和黎巴嫩报告的病例数最多。分析表明，最普遍的序列类型是 ST10、ST101 和 ST1011，所有这些大肠埃希菌菌株都与显著的可乐定耐药性水平和多种抗菌药耐药性特征有关：通过分析来自不同阿拉伯国家的各种研究结果，本综述为今后的研究奠定了重要基础，并强调有必要加强监测和有针对性的干预措施，以应对该地区迫在眉睫的大肠菌素耐药性威胁：系统综述注册：prospero crd42024584379。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.