Current status and future developments of biopolymer microspheres in the field of pharmaceutical preparation

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-10-21 DOI:10.1016/j.cis.2024.103317

Taixia Wu , Han Wu , Qiubo Wang , Xiangqiong He , Pengbao Shi , Bing Yu , Hailin Cong , Youqing Shen

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Abstract

Polymer composite microspheres offer several advantages including highly designable structural properties, adjustable micro-nano particle size distribution, easy surface modification, large specific surface area, and high stability. These features make them valuable in various fields such as medicine, sensing, optics, and display technologies, with significant applications in clinical diagnostics, pathological imaging, and drug delivery in the medical field. Currently, microspheres are primarily used in biomedical research as long-acting controlled-release agents and targeted delivery systems, and are widely applied in bone tissue repair, cancer treatment, and wound healing. Different types of polymer microspheres offer distinct advantages and application prospects. Efforts are ongoing to transition successful experimental research to industrial production by expanding various fabrication technologies. This article provides an overview of materials used in microsphere manufacturing, different fabrication methods, modification techniques to enhance their properties and applications, and discusses the role of microspheres in drug delivery engineering.

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生物聚合物微球在药物制剂领域的现状和未来发展。

聚合物复合微球具有多种优势，包括结构特性可高度设计、微纳米粒径分布可调、表面改性容易、比表面积大以及稳定性高。这些特点使微球在医学、传感、光学和显示技术等多个领域具有重要价值，在医疗领域的临床诊断、病理成像和药物输送等方面有着重要应用。目前，微球在生物医学研究中主要用作长效控释剂和靶向给药系统，并广泛应用于骨组织修复、癌症治疗和伤口愈合。不同类型的聚合物微球具有不同的优势和应用前景。目前正在努力通过扩展各种制造技术，将成功的实验研究转化为工业生产。本文概述了用于制造微球的材料、不同的制造方法、提高微球性能和应用的改性技术，并讨论了微球在给药工程中的作用。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.