Effects of cystic fibrosis transmembrane conductance regulator potentiators on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Xi Yan, Quzhen Deqing, Feng Yu, Tao Wang, Dan Xu, Fuqiang Wen, Jun Chen
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Abstract

Introduction: Excessive mucus secretion is pivotal in chronic obstructive pulmonary disease (COPD) pathophysiology, particularly in chronic bronchitis phenotypes. Cystic fibrosis transmembrane conductance regulator (CFTR) has been implicated in COPD-related hypersecretion with acquired dysfunction, and emerged as a therapeutic target. However, the clinical efficacy of CFTR-potentiators in COPD remains controversial.

Methods: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal (CSTJ), and Wanfang Database to retrieve eligible studies published before 28 May 2024.

Results: A total of 1172 COPD patients were included, meta-analysis showed that CFTR-potentiators significantly increased forced expiratory volume in 1 s (FEV1) and decreased sweat chloride and fibrinogen levels, with moderate-to-high quality evidence. However, no significant effects were observed on the percentage of detected FEV1 to predicted FEV1 (FEV1% predicted), forced vital capacity (FVC), COPD assessment test (CAT) score, St. George's Respiratory Questionnaire (SGRQ) score, or acute exacerbation times, with low-to-moderate quality evidence.

Conclusion: Our meta-analysis demonstrated CFTR-potentiators' potential efficacy in increasing FEV1, decreasing sweat chloride and fibrinogen levels, despite limited impacts on FEV1% predicted, FVC, CAT score, SGRQ score, and acute exacerbations, underscoring the necessity for future research to evaluate its effects on mucus hypersecretion, acute exacerbations, hospitalizations, and mortality in COPD management. Review registration PROSPERO Identifier: CRD42024538708.

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囊性纤维化跨膜传导调节剂增效剂对慢性阻塞性肺病临床疗效的影响:系统综述和荟萃分析。
简介:粘液分泌过多是慢性阻塞性肺病(COPD)病理生理学的关键,尤其是在慢性支气管炎表型中。囊性纤维化跨膜传导调节器(CFTR)与慢性阻塞性肺病相关的高分泌和后天功能障碍有关,并已成为治疗靶点。然而,CFTR 促效剂对慢性阻塞性肺疾病的临床疗效仍存在争议:我们检索了PubMed、Embase、Cochrane图书馆、中国国家知识基础设施(CNKI)、中国科技期刊(CSTJ)和万方数据库,以检索2024年5月28日之前发表的符合条件的研究:荟萃分析表明,CFTR促进剂能显著增加1秒用力呼气容积(FEV1),降低汗液氯化物和纤维蛋白原水平,证据质量为中高水平。然而,在检测到的 FEV1 与预测 FEV1 的百分比(FEV1% 预测值)、用力肺活量(FVC)、慢性阻塞性肺病评估测试(CAT)评分、圣乔治呼吸问卷(SGRQ)评分或急性加重时间方面未观察到明显效果,证据质量为中低:CRD42024538708.Conclusion:我们的荟萃分析表明 CFTR 促效剂在增加 FEV1、降低汗液氯化物和纤维蛋白原水平方面具有潜在疗效,尽管其对 FEV1 预测值、FVC、CAT 评分、SGRQ 评分和急性加重的影响有限:CRD42024538708。
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