Persistent chemiluminescence-based nanosensor for portable point-of-care testing of H2O2

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-10-28 DOI:10.1007/s00604-024-06794-3

Yueliang Wang, Xiying Chen, Zhanhui Tao, Jingya Zhou, Hanyue Sun, Xian Li, Liyu Shi, Yaqing Liu

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Abstract

A novel glow-type chemiluminescence (CL)-based nanosensing system was developed for sensitive and rapid point-of-care testing (POCT) of H₂O₂ in food. CuSe nanoparticles (CuSe_NPs) have excellent peroxidase-like activity. After being modified with thiols of 4-mercaptophenylboronic acid (MBA) (CuSe_NPs@MBA), luminol can be catalyzed to produce long-lasting CL in the presence of H₂O₂. The possible reason for the long-lasting glow-type CL behavior was explored. Under the optimized condition, H₂O₂ can be sensitively detected with improved repeatability. The limit of detection is as low as 0.30 μM. To meet the requirement of in situ and outside of laboratory detection, a 3D-printed portable device was designed which can eliminate the environmental interference to improve detection accuracy. The developed multifunctional platform also has the advantages of simple operation and low cost, suggesting its great potential for applications in food and agricultural fields.

Graphical Abstract

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用于便携式 H2O2 床旁检测的基于持久化学发光的纳米传感器

研究人员开发了一种基于辉光型化学发光（CL）的新型纳米传感系统，用于灵敏、快速地对食品中的 H2O2 进行床旁检测（POCT）。铜硒纳米粒子（CuSeNPs）具有优异的过氧化物酶样活性。经 4-巯基苯硼酸（MBA）硫醇修饰（CuSeNPs@MBA）后，发光酚可在 H2O2 的催化下产生长效 CL。研究人员探讨了产生长效辉光型发光现象的可能原因。在优化的条件下，H2O2 可以被灵敏地检测到，而且重复性更好。检测限低至 0.30 μM。为满足原位和实验室外检测的要求，设计了一种三维打印的便携式装置，可消除环境干扰，提高检测精度。所开发的多功能平台还具有操作简单、成本低廉等优点，在食品和农业领域的应用潜力巨大。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.