Recent advances in the enantioselective synthesis of chiral sulfones via asymmetric hydrogenation.

Abstract

Chiral sulfones are key structural motifs that extensively exist in natural products, drugs, and biologically active compounds. During the past few decades, rapid development has been made with respect to the highly enantioselective synthesis of chiral sulfones, in which the catalytic asymmetric hydrogenation of unsaturated sulfones provides an efficient and powerful methodology to construct chiral sulfones and their derivatives. This review highlights the progress achieved in transition metal (ruthenium, rhodium, iridium, and nickel) catalyzed direct asymmetric hydrogenation of a variety of unsaturated sulfones from the aspects of the substrate scope, catalytic mechanisms, and applications in the synthesis of biologically active molecules.