[Research progress on the effects of mitochondrial-associated endoplasmic reticulum membranes tethering proteins interaction on cerebral ischemia/reperfusion].

Q3 Medicine 生理学报 Pub Date : 2024-10-25
Meng-Ling Huang, Li-Hong Zhang, Chang-Yu Gu, Jing-Jing Li, Rui-Qing Li, Xiao-Dong Feng, Jing Gao, Jian Guo
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引用次数: 0

Abstract

Cerebral ischemia/reperfusion injury (CIRI) refers to secondary damage caused by reperfusion of blood flow following ischemic stroke. Its mechanism is complex, involving mitochondrial energy metabolism disorders, Ca2+ overload, oxidative stress, apoptosis, inflammatory responses, excitatory amino acid toxicity, blood-brain barrier disruption, excessive NO synthesis, and cell necrosis etc. Mitochondrial-associated endoplasmic reticulum membranes (MAMs) are specialized regions of the endoplasmic reticulum that play crucial roles in various cellular processes, including regulation of mitochondrial morphology and activity, lipid metabolism, Ca2+ homeostasis, and cell viability. Existing research has confirmed that mitochondrial homeostasis, cell apoptosis, and endoplasmic reticulum stress are closely related to MAMs. This article summarizes the research progress on MAMs in recent years, reviews the biological functions of MAMs and the localization of tethering proteins, analyzes the signaling between mitochondria and the endoplasmic reticulum, explores the impact of MAMs tethering proteins interaction on Ca2+ signaling and cell viability during the pathophysiological process of CIRI, aiming to provide a theoretical basis for the treatment of CIRI.

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[线粒体相关内质网膜系链蛋白相互作用对脑缺血再灌注影响的研究进展]。
脑缺血再灌注损伤(CIRI)是指缺血性脑卒中后血流再灌注引起的继发性损伤。其机制复杂,涉及线粒体能量代谢紊乱、Ca2+ 超载、氧化应激、细胞凋亡、炎症反应、兴奋性氨基酸毒性、血脑屏障破坏、NO 过度合成和细胞坏死等。线粒体相关内质网膜(MAMs)是内质网的特殊区域,在各种细胞过程中发挥着至关重要的作用,包括线粒体形态和活性、脂质代谢、钙离子平衡和细胞活力的调节。现有研究证实,线粒体稳态、细胞凋亡和内质网应激与 MAMs 密切相关。本文总结了近年来MAMs的研究进展,综述了MAMs的生物学功能和系链蛋白的定位,分析了线粒体与内质网之间的信号传导,探讨了CIRI病理生理过程中MAMs系链蛋白相互作用对Ca2+信号传导和细胞活力的影响,旨在为CIRI的治疗提供理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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