Repeatability, Reproducibility, and Observer Variability of Cortical T1 Mapping for Renal Tissue Characterization.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-28 DOI:10.1002/jmri.29602

Magdalena Nowak, Markus Henningsson, Tom Davis, Najib Chowdhury, Andrea Dennis, Carolina Fernandes, Helena Thomaides Brears, Matthew D Robson

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Abstract

Background: The global rise in kidney diseases underscores the need for reliable, noninvasive imaging biomarkers. Among these, renal cortical T1 has shown promise but further technical validation is still required.

Purpose: To evaluate the repeatability, reproducibility, and observer variability of kidney cortical T1 mapping in human volunteers without known renal disease.

Study type: Prospective.

Subjects: Three cohorts without renal disease: 1) 25 volunteers (median age 38 [interquartile range, IQR: 28-42] years, female N = 11) for scan-rescan assessments on GE 1.5 T and Siemens 1.5 T; 2) 29 volunteers (median age 29 [IQR: 24-40] years, female N = 15) for scan-rescan assessments on Siemens 3 T; and 3) 16 volunteers (median age 34 [IQR: 31-42] years, female N = 8) for cross-scanner reproducibility.

Field strength/sequences: 1.5 T and 3 T, a modified Look-Locker imaging (MOLLI) sequence with a balanced steady-state free precession (bSSFP) readout.

Assessment: Kidney cortical T1 data was acquired on GE 1.5 T scanner, Siemens 1.5 T and 3 T scanners. Within-scanner repeatability and inter/intra-observer variability: GE 1.5 T and Siemens 1.5 T, and cross-scanner manufacturer reproducibility: Siemens 1.5 T-GE 1.5 T.

Statistical tests: Bland Altman analysis, coefficient of variation (CoV), intra-class coefficient (ICC), and repeatability coefficient (RC).

Results: Renal cortical T1 mapping showed high repeatability and reliability across scanner field strengths and manufacturers (repeatability: CoV 1.9%-2.8%, ICC 0.79-0.88, pooled RC 73 msec; reproducibility: CoV 3.0%, ICC 0.75, RC 90 msec). The method also showed robust observer variability (CoV 0.6%-1.4%, ICC 0.93-0.98, RC 22-48 msec).

Data conclusion: Kidney cortical T1 mapping is a highly repeatable and reproducible method across MRI manufacturers, field strengths, and observer conditions.

Evidence level: 2 TECHNICAL EFFICACY: Stage 2.

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用于肾组织特征描述的皮质 T1 映像的重复性、再现性和观察者变异性。

背景：全球肾脏疾病发病率的上升凸显了对可靠、无创成像生物标志物的需求。目的：评估无已知肾脏疾病的人类志愿者肾皮质 T1 图谱的可重复性、再现性和观察者变异性：研究类型：前瞻性：研究类型：前瞻性：1）25 名志愿者（中位年龄 38 [四分位间距：28-42]岁，女性 N = 11）在通用电气 1.5 T 和西门子 1.5 T 上进行扫描-扫描评估；2）29 名志愿者（中位年龄 29 [四分位间距：24-40]岁，女性 N = 15）在西门子 3 T 上进行扫描-扫描评估；3）16 名志愿者（中位年龄 34 [四分位间距：31-42]岁，女性 N = 8）进行跨扫描仪重现性评估：场强/序列：1.5 T 和 3 T，改良锁定成像（MOLLI）序列，平衡稳态自由前驱（bSSFP）读出：在通用电气 1.5 T 扫描仪、西门子 1.5 T 和 3 T 扫描仪上获取肾皮质 T1 数据。扫描仪内重复性和观察者间/观察者内变异性：通用电气 1.5 T 扫描仪和西门子 1.5 T 扫描仪，以及跨扫描仪制造商的可重复性：统计测试：统计检验：Bland Altman 分析、变异系数 (CoV)、类内系数 (ICC) 和重复性系数 (RC)：结果：肾皮质 T1 图谱在不同扫描仪场强和制造商之间显示出较高的重复性和可靠性（重复性：CoV 1.9%-2.9重复性：CoV 1.9%-2.8%，ICC 0.79-0.88，RC 73 毫秒；再现性：CoV 3.0%，ICC 0.79-0.88，RC 73 毫秒：CoV 3.0%，ICC 0.75，RC 90 毫秒）。该方法还显示出很强的观察者变异性（CoV 0.6%-1.4%，ICC 0.93-0.98，RC 22-48 毫秒）：数据结论：肾皮质 T1 图谱是一种具有高度可重复性和再现性的方法，适用于不同的 MRI 制造商、磁场强度和观察者条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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